Stem cell tuning.
Researchers from Tokyo Metropolitan University have quantified how mesenchymal stem cells respond to the mechanical stiffness of their environments. Specific proteins can be localized in the cell nucleus depending on the stiffness. Their findings will help scientists control the state of stem cells in medical treatments.
Their work has been published in Analytical Sciences: https://doi.org/10.2116/analsci.20SCP02
#sciencenews #biology #genetics #medicine
Researchers from Tokyo Metropolitan University have quantified how mesenchymal stem cells respond to the mechanical stiffness of their environments. Specific proteins can be localized in the cell nucleus depending on the stiffness. Their findings will help scientists control the state of stem cells in medical treatments.
Their work has been published in Analytical Sciences: https://doi.org/10.2116/analsci.20SCP02
#sciencenews #biology #genetics #medicine
J-STAGE
Designing Elastic Modulus of Cell Culture Substrate to Regulate YAP and RUNX2 Localization for Controlling Differentiation of Human…
To establish a guideline for the design of cell culture substrates to control human mesenchymal stem cell (MSC) differentiation, we quantitatively cha …
Down the nano-hole.
A sensing technique developed at the University of Cambridge has been used to reveal the fundamental physics governing the transport of DNA threads through nanopores. They assembled DNA molecules with ‘bumps’ at specific locations that could be used to track the passage of the molecule.
The study is published in Nature Physics: http://dx.doi.org/10.1038/s41567-021-01268-2
#sciencenews #genetics #nano
A sensing technique developed at the University of Cambridge has been used to reveal the fundamental physics governing the transport of DNA threads through nanopores. They assembled DNA molecules with ‘bumps’ at specific locations that could be used to track the passage of the molecule.
The study is published in Nature Physics: http://dx.doi.org/10.1038/s41567-021-01268-2
#sciencenews #genetics #nano
Nature Physics
Dynamics of driven polymer transport through a nanopore
Nature Physics - A study of the dynamics of polymer translocation through synthetic nanopores provides a direct observation of tension propagation—a non-equilibrium description of the...
Gene editing in space.
Researchers from the Genes in Space program have developed and successfully demonstrated a novel method for studying how cells repair damaged DNA in space. They used CRISPR/Cas9 genome editing to create controlled damage to DNA strands, before observing the self-repair mechanisms in detail.
Their methods are described in PLOS ONE: http://dx.doi.org/10.1371/journal.pone.0253403
#sciencenews #biology #genetics
Researchers from the Genes in Space program have developed and successfully demonstrated a novel method for studying how cells repair damaged DNA in space. They used CRISPR/Cas9 genome editing to create controlled damage to DNA strands, before observing the self-repair mechanisms in detail.
Their methods are described in PLOS ONE: http://dx.doi.org/10.1371/journal.pone.0253403
#sciencenews #biology #genetics
journals.plos.org
A CRISPR-based assay for the study of eukaryotic DNA repair onboard the International Space Station
As we explore beyond Earth, astronauts may be at risk for harmful DNA damage caused by ionizing radiation. Double-strand breaks are a type of DNA damage that can be repaired by two major cellular pathways: non-homologous end joining, during which insertions…