https://www.vegfrinhibitor.com/2016/03/17/alanine-substitution-of-the-two-conserved-glutamic-acid-residues-and-the-conserved-aspartic-acid-residue-glu-glu-asp-in-the-p120binding-site-of-e-cadherin-has-been-revealed-to-do-away-with-its-conve/