The development of antimicrobial chemotherapy began in 1935 with the discovery of the sulfonamide

these have a rapid lethal action, e.g. penicillins,cephalosporins & aminoglycosides

penicillin

ampicillin & ciprofloxacin active mainly against G-ve organisms

penicillins & cephalosporins interfere with cell wall synthesis and cause bacteriolysis

cause disruption of the cytoplasmic membrane and leakage of cellular proteins & nucleotides leading to cell death

Many chemotherapeutic block protein synthesis by acting on the 70s or 80s subunit of bacterial ribosomes

quinolones

Regarding to resistance to aminoglycosides

M. Tuberculosis, which survive for years in the tissues & their resistance is due to metabolic inactivity

One of the following is false about Plasmid

streptomycin resistance can result from a mutation in the chromosomal gene that controls the receptor for streptomycin located in the 50s bacterial ribosome

In hospitals its common finding that about 90 % of Staphylococcus aureus strains are resistant to penicillin

effect on the 8th cranial nerve leading to deafness

The use of benzathine penicillin G injections every 3-4 weeks to prevent reinfection with

One of the following is false

Atropine overdose may cause which one of the following