An 8-year-old boy who presented with intense itchy rash involving face, chest, abdomen and extremities progressively over 4 days with fever and malaise. The striking feature is the different shapes of the rash (macules - papule - pustule - crusted vesicles).

The following Questions refer to the following patient case: "A 76-year-old woman has pain on the right side of the trunk, nausea, vomiting, and generalised weakness. Examination shows a vesicular rash involving the T-10 to T-12 dermatomes. The diagnosis was confirmed and the treatment with acyclovir is prescribed in a dose of 800mg/day for 10 days."

A three-year-old boy with acute lymphoblastic leukemia who had developed fever and rash in the past few days, was seen by a physician and decided that, in the setting of the story, the rash is more likely to be primary varicella zoster infection.

A five-year-old girl presented with history of fever for two weeks with sore throat. On examination, she was febrile (38.3C), not pale, with bilateral cervical lymph node enlargement (3x3 cm largest). Oropharyngeal examination showed an exudative tonsillitis with petechial rash over the soft palate. Abdominal examination revealed soft palpable spleen. Initial CBC showed Leukocytosis with absolute lymphocytosis and normal haemoglobin and platelet count.

A 10 months old previously healthy
infant presented with history of an
abrupt onset of high fever that reached 40 C, which lasts for 3 days
with nonspecific complaints and
was accompanied by single episode
of generalized tonic clonic convulsion attributed to the rapid
rise of temperature by the family
physician. On the fourth day, the
mother noticed that temperature
had decreased rapidly with the
onset of a mild, pink rash over the trunk.

Herpes viruses
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