كل ما تريد معرفته عن
Bone Marrow Transplant (BMT)

📋 Definition:

* BMT is a potentially curative treatment for various hematologic malignancies and disorders.
* It involves replacing diseased or nonfunctional bone marrow with healthy stem cells, enabling the patient to produce healthy blood cells.


🔬 Applications:

* BMT is considered for a range of conditions, including:
* Acute leukemias
* Lymphomas
* Myeloma
* Aplastic anemia
* Sickle cell disease

🩸Types of BMT:

* Autologous BMT: Utilizes the patient's own stem cells collected prior to conditioning.
* Allogeneic BMT: Employs stem cells from a matched donor, offering a graft-versus-tumor (GVT) effect in malignancies.

🥼 BMT Process:

1. Conditioning Regimen: High-dose chemotherapy and/or radiation therapy eradicate residual malignant cells and immunosuppress the recipient to prepare for engraftment.
2. Stem Cell Collection:
* Autologous: Bone marrow aspiration or peripheral blood stem cell (PBSC) apheresis.
* Allogeneic: PBSC apheresis from a matched donor (HLA-matched sibling or unrelated donor registry).
3. Stem Cell Infusion: Administered intravenously through a central venous catheter.
4. Engraftment: Period where infused stem cells migrate to the bone marrow and begin producing new blood cells.
5. Post-Transplant Care: Close monitoring for engraftment, infections, and graft-versus-host disease (GVHD).

⚕️ Considerations:

* BMT is a complex procedure with significant potential for complications.
* Patient selection requires careful evaluation of disease status, comorbidities, and performance status.
* Supportive care plays a vital role throughout the transplant journey.


🧠 Conclusion:

BMT remains a powerful therapeutic tool offering the potential for cure in various hematologic conditions. However, thorough patient selection, meticulous management, and a multidisciplinary approach are crucial for successful outcomes.

🌐 Reference ➡️ Mayo Clinic

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GLP-1 مقارنة
by Dr Mohamed Adel

#Endocrine

#Pharmacy

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🪴 الجلسة (3) من جلسات طفرة اليوم الواحد (هذا المنشور)

Enjoy🫀


▶️ Watch this video https://www.facebook.com/share/Bu9DuvNn2GEXwVSZ/?mibextid=WC7FNe

قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

كل ما تريد معرفته عن
Post-Traumatic Stress Disorder (PTSD)

📋 Definition: PTSD is a mental health disorder that develops following exposure to a traumatic event that involved actual or threatened death, serious injury.

🧠 Causes: Trauma can come in many forms, including:
* Combat or war experiences
* Serious accidents
* Witnessing traumatic events

⚕️ Symptoms: PTSD symptoms are typically categorized into four groups:

* Intrusion: Flashbacks, nightmares, and unwanted thoughts or images about the traumatic event.
* Avoidance: Avoiding places, people, and situations that trigger memories of the trauma.
* Negative Cognitions and Mood: Difficulty concentrating, negative thoughts about oneself or the world, feeling hopeless, guilty, or ashamed.
* Arousal and Reactivity: Difficulty sleeping, hypervigilance (being on high alert), irritability, or outbursts of anger.

🥼 Diagnosis and Treatment: PTSD is diagnosed by a mental health professional using established criteria. Effective treatments include psychotherapy (such as Cognitive Behavioral Therapy) and medication.

🌐 Reference ➡️ Clevelandclinic

#PDFology

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#quiz
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تفريغ د عبد المتعال فودة CNS

Therapy of epilepsy
Part3: 2nd generation of AEDs

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Neurology

#Tafreghat

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إيه دور Bromocriptine في علاج Cardiopathy؟

🔍 What is Peripartum Cardiomyopathy (PPCM)?
A weakening of the heart muscle that happens in the later stages of pregnancy or the first few months after delivery.

🩺 Symptoms include:
Shortness of breath, fatigue, and swelling in the legs.

💊 What is Bromocriptine?
A medication that mimics dopamine, a brain chemical. Used to treat a variety of conditions, including Parkinson's disease and infertility.

🔬 How might Bromocriptine help with PPCM?
May help by lowering prolactin levels.
Prolactin is a hormone that increases during pregnancy and may contribute to heart dysfunction in PPCM.

🌟 Benefits of Bromocriptine for PPCM:
Studies suggest it may improve heart function recovery in women with PPCM.
May be associated with a lower risk of complications and death.
May be well-tolerated with minimal side effects.

⚠️ Important Considerations:
More research is needed to confirm the long-term benefits and safety of bromocriptine for PPCM.
It should be used under the supervision of a healthcare professional experienced in managing heart failure.
It's typically used in addition to standard heart failure therapy. Not a first-line treatment, but may be an option for women who don't respond well to standard therapy.

💡 Overall:
Bromocriptine shows promise as a treatment for PPCM, potentially improving heart function and outcomes.
More research is needed, but it may be a valuable option in some cases.

#PDFology
#غزة 🇵🇸

قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]