قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

🚨 اعلانات التلجرام تظهر بشكل إجباري ولا يمكن إلغائها فضلاً عمل ريبورت لأي إعلان قد يظهر به شبهة حرمانية 🚨

لأن فيه ناس بتتشتت من كثرة كتيبات الدعاء، هعنمل جلسة (اجمع قلبك) كجلسة مركزة للدعاء إن شاء الله بتمام الساعة 5 بتوقيت مصر..
ترقبوها..

كل ما تريد معرفته عن Fibromyalgia

Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and a variety of associated symptoms. Here's a concise overview for healthcare professionals:


📌 Core Characteristics:
* Pain: Widespread chronic pain affecting multiple body areas, often described as deep, achy, or burning.
* Tender Points: While no longer the sole diagnostic criteria, specific areas (18 in total) around the neck, shoulders, hips, knees, and chest become tender upon palpation.

🔍 Associated Symptoms:
* Fatigue: A hallmark symptom, often described as profound and persistent exhaustion.
* Sleep Disturbances: Difficulty falling asleep, staying asleep, or achieving restful sleep.
* Cognitive Difficulties ("Fibro Fog"): Problems with memory, concentration, and focus.
* Headaches: Frequent or recurring headaches of varying types.
* Mood Issues: Anxiety and depression are commonly comorbid with fibromyalgia.

🔬 Diagnosis: There is no single definitive test. Diagnosis relies on a comprehensive evaluation, including:
* Detailed history focusing on pain location, duration, and characteristics.
* Physical examination to assess tender points and overall health.
* Exclusion of other conditions that may mimic fibromyalgia.

⚙️ Management: While there's no cure, treatment aims to improve function and quality of life. This may include:
* Pharmacological Therapy: Medications to manage pain, sleep disturbances, and mood issues.
* Physical Therapy: To improve flexibility, strength, and reduce pain.
* Stress Management Techniques: Cognitive-behavioral therapy and relaxation techniques can be helpful.
* Exercise Programs: Regular exercise, tailored to individual capabilities, can significantly improve symptoms.

🌐 Reference ➡️ Clevelandclinic

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إيه الفرق بين
Ezetimibe 🆚 Statins?

🔬 Mechanism of Action:

* Ezetimibe: Acts as a cholesterol absorption inhibitor, specifically targeting Niemann-Pick C1 Like 1 (NPC1L1) protein in the small intestine.
This reduces dietary cholesterol uptake.
* Statins: Function as HMG-CoA reductase inhibitors, acting within the liver to decrease cholesterol synthesis.

📉 LDL-C Reduction:

* Ezetimibe: Provides a modest reduction of LDL-C (low-density lipoprotein cholesterol) by 15-22%.
* Statins: Offer a more potent effect, lowering LDL-C by 30-50%.

⚕️ Clinical Use:

* Ezetimibe: May be used as monotherapy for mild hypercholesterolemia or in combination therapy with statins for patients requiring a more aggressive LDL-C reduction strategy.
* Statins: Represent the first-line treatment for lowering LDL-C due to their efficacy.

💊 Side Effect Profile:

* Ezetimibe: Generally well-tolerated with minimal adverse effects reported.
* Statins: May be associated with muscle aches, fatigue, and, in rare cases, liver dysfunction.

🤔 Considerations for Selection:

* Individual risk factors for cardiovascular disease.
* Baseline LDL-C levels.
* Patient tolerability to medications.

🔚 Conclusion:

Both ezetimibe and statins play a role in managing cholesterol levels. Statins offer a more robust LDL-C reduction, making them the preferred initial therapy.
Ezetimibe serves as a valuable tool for patients with statin intolerance or those requiring additional LDL-C lowering alongside a statin regimen.
The optimal choice depends on individual patient characteristics and should be determined in consultation with a physician.

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قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

🚨 اعلانات التلجرام تظهر بشكل إجباري ولا يمكن إلغائها فضلاً عمل ريبورت لأي إعلان قد يظهر به شبهة حرمانية 🚨

إيه الفرق بين
Metoclopramide 🆚 Ondansetron

🧠 Mechanism of Action:
- Metoclopramide:
Primarily works as a dopamine receptor antagonist.
It enhances gastrointestinal motility and accelerates gastric emptying, making it effective for nausea and vomiting related to gastroparesis and gastrointestinal disorders.
- Ondansetron:
Functions as a selective serotonin 5-HT3 receptor antagonist.
It blocks the action of serotonin, a natural substance that may cause nausea and vomiting, particularly effective in chemotherapy-induced nausea and postoperative nausea.

💊 Indications:
- Metoclopramide:
Commonly prescribed for nausea and vomiting related to gastroparesis, migraine headaches, and postoperative recovery.
It is also used for gastroesophageal reflux disease (GERD) when other treatments fail.
- Ondansetron:
Primarily used to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. It's also useful for treating nausea and vomiting in pregnancy when other treatments are ineffective.

⚖️ Efficacy:
- Metoclopramide:
Effective for a broader range of gastrointestinal-related nausea and vomiting due to its prokinetic effects. However, its efficacy may vary based on the underlying cause.
- Ondansetron:
Highly effective for nausea and vomiting induced by chemotherapy and surgery.
Its targeted action on serotonin receptors makes it very effective in these contexts.

🛡️ Side Effects:
- Metoclopramide:
Can cause extrapyramidal symptoms (such as tardive dyskinesia), drowsiness, fatigue, and diarrhea.
Long-term use can lead to more severe neurological side effects.
- Ondansetron: Generally well-tolerated, but can cause headaches, constipation, and dizziness.
It has a lower risk of severe side effects compared to metoclopramide.

🔒 Safety and Precautions:
- Metoclopramide:
Not recommended for long-term use due to the risk of serious side effects.
It should be used with caution in patients with a history of depression or Parkinson's disease.
- Ondansetron:
Considered safer for long-term use compared to metoclopramide. However, it should be used cautiously in patients with a history of heart rhythm disorders.

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