Forwarded from PDFology (Basem Medhat)
Pyridostigmine is drug of choice in treatment of?
Anonymous Quiz
26%
A. Atropine toxicity
60%
B. Myasthenia gravis
12%
C. Alzheimer
3%
D. Megacolon
Forwarded from PDFology (Basem Medhat)
تلخيصات طبية
Photo
إيه الفرق بين
Ezetimibe 🆚 Statins?
🔬 Mechanism of Action:
* Ezetimibe: Acts as a cholesterol absorption inhibitor, specifically targeting Niemann-Pick C1 Like 1 (NPC1L1) protein in the small intestine.
This reduces dietary cholesterol uptake.
* Statins: Function as HMG-CoA reductase inhibitors, acting within the liver to decrease cholesterol synthesis.
📉 LDL-C Reduction:
* Ezetimibe: Provides a modest reduction of LDL-C (low-density lipoprotein cholesterol) by 15-22%.
* Statins: Offer a more potent effect, lowering LDL-C by 30-50%.
⚕️ Clinical Use:
* Ezetimibe: May be used as monotherapy for mild hypercholesterolemia or in combination therapy with statins for patients requiring a more aggressive LDL-C reduction strategy.
* Statins: Represent the first-line treatment for lowering LDL-C due to their efficacy.
💊 Side Effect Profile:
* Ezetimibe: Generally well-tolerated with minimal adverse effects reported.
* Statins: May be associated with muscle aches, fatigue, and, in rare cases, liver dysfunction.
🤔 Considerations for Selection:
* Individual risk factors for cardiovascular disease.
* Baseline LDL-C levels.
* Patient tolerability to medications.
🔚 Conclusion:
Both ezetimibe and statins play a role in managing cholesterol levels. Statins offer a more robust LDL-C reduction, making them the preferred initial therapy.
Ezetimibe serves as a valuable tool for patients with statin intolerance or those requiring additional LDL-C lowering alongside a statin regimen.
The optimal choice depends on individual patient characteristics and should be determined in consultation with a physician.
#PDFology
#Vs
#رفح_الان 🇵🇸
Ezetimibe 🆚 Statins?
🔬 Mechanism of Action:
* Ezetimibe: Acts as a cholesterol absorption inhibitor, specifically targeting Niemann-Pick C1 Like 1 (NPC1L1) protein in the small intestine.
This reduces dietary cholesterol uptake.
* Statins: Function as HMG-CoA reductase inhibitors, acting within the liver to decrease cholesterol synthesis.
📉 LDL-C Reduction:
* Ezetimibe: Provides a modest reduction of LDL-C (low-density lipoprotein cholesterol) by 15-22%.
* Statins: Offer a more potent effect, lowering LDL-C by 30-50%.
⚕️ Clinical Use:
* Ezetimibe: May be used as monotherapy for mild hypercholesterolemia or in combination therapy with statins for patients requiring a more aggressive LDL-C reduction strategy.
* Statins: Represent the first-line treatment for lowering LDL-C due to their efficacy.
💊 Side Effect Profile:
* Ezetimibe: Generally well-tolerated with minimal adverse effects reported.
* Statins: May be associated with muscle aches, fatigue, and, in rare cases, liver dysfunction.
🤔 Considerations for Selection:
* Individual risk factors for cardiovascular disease.
* Baseline LDL-C levels.
* Patient tolerability to medications.
🔚 Conclusion:
Both ezetimibe and statins play a role in managing cholesterol levels. Statins offer a more robust LDL-C reduction, making them the preferred initial therapy.
Ezetimibe serves as a valuable tool for patients with statin intolerance or those requiring additional LDL-C lowering alongside a statin regimen.
The optimal choice depends on individual patient characteristics and should be determined in consultation with a physician.
#PDFology
#Vs
#رفح_الان 🇵🇸
Forwarded from Coursemia
Challenging Question of the week
Let's do it
https://www.facebook.com/photo/?fbid=842851394531460&set=a.197108452439094
Let's do it
https://www.facebook.com/photo/?fbid=842851394531460&set=a.197108452439094
Forwarded from PDFology (Basem Medhat)
Diabetes medications Dr Tarek AlMaqtari .pdf
22.4 MB
Forwarded from PDFology (Basem Medhat)
A two year-old girl is diagnosed with a first case of otitis media.
Which of the following is the best treatment for this patient?
Which of the following is the best treatment for this patient?
Anonymous Quiz
12%
Trimethoprim-sulfamethoxazole
28%
Azithromycin
4%
Linezolid
56%
High-dose amoxicillin
Forwarded from PDFology (Basem Medhat)
سورة الكهف.pdf
3.7 MB
قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.
﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]
🚨 اعلانات التلجرام تظهر بشكل إجباري ولا يمكن إلغائها فضلاً عمل ريبورت لأي إعلان قد يظهر به شبهة حرمانية 🚨
﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]
🚨 اعلانات التلجرام تظهر بشكل إجباري ولا يمكن إلغائها فضلاً عمل ريبورت لأي إعلان قد يظهر به شبهة حرمانية 🚨
Forwarded from PDFology (Basem Medhat)
تلخيصات طبية
Photo
إيه الفرق بين
Metoclopramide 🆚 Ondansetron
🧠 Mechanism of Action:
- Metoclopramide:
Primarily works as a dopamine receptor antagonist.
It enhances gastrointestinal motility and accelerates gastric emptying, making it effective for nausea and vomiting related to gastroparesis and gastrointestinal disorders.
- Ondansetron:
Functions as a selective serotonin 5-HT3 receptor antagonist.
It blocks the action of serotonin, a natural substance that may cause nausea and vomiting, particularly effective in chemotherapy-induced nausea and postoperative nausea.
💊 Indications:
- Metoclopramide:
Commonly prescribed for nausea and vomiting related to gastroparesis, migraine headaches, and postoperative recovery.
It is also used for gastroesophageal reflux disease (GERD) when other treatments fail.
- Ondansetron:
Primarily used to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. It's also useful for treating nausea and vomiting in pregnancy when other treatments are ineffective.
⚖️ Efficacy:
- Metoclopramide:
Effective for a broader range of gastrointestinal-related nausea and vomiting due to its prokinetic effects. However, its efficacy may vary based on the underlying cause.
- Ondansetron:
Highly effective for nausea and vomiting induced by chemotherapy and surgery.
Its targeted action on serotonin receptors makes it very effective in these contexts.
🛡️ Side Effects:
- Metoclopramide:
Can cause extrapyramidal symptoms (such as tardive dyskinesia), drowsiness, fatigue, and diarrhea.
Long-term use can lead to more severe neurological side effects.
- Ondansetron: Generally well-tolerated, but can cause headaches, constipation, and dizziness.
It has a lower risk of severe side effects compared to metoclopramide.
🔒 Safety and Precautions:
- Metoclopramide:
Not recommended for long-term use due to the risk of serious side effects.
It should be used with caution in patients with a history of depression or Parkinson's disease.
- Ondansetron:
Considered safer for long-term use compared to metoclopramide. However, it should be used cautiously in patients with a history of heart rhythm disorders.
#PDFology
#Vs
#ابو_عبيدة 🇵🇸
Metoclopramide 🆚 Ondansetron
🧠 Mechanism of Action:
- Metoclopramide:
Primarily works as a dopamine receptor antagonist.
It enhances gastrointestinal motility and accelerates gastric emptying, making it effective for nausea and vomiting related to gastroparesis and gastrointestinal disorders.
- Ondansetron:
Functions as a selective serotonin 5-HT3 receptor antagonist.
It blocks the action of serotonin, a natural substance that may cause nausea and vomiting, particularly effective in chemotherapy-induced nausea and postoperative nausea.
💊 Indications:
- Metoclopramide:
Commonly prescribed for nausea and vomiting related to gastroparesis, migraine headaches, and postoperative recovery.
It is also used for gastroesophageal reflux disease (GERD) when other treatments fail.
- Ondansetron:
Primarily used to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. It's also useful for treating nausea and vomiting in pregnancy when other treatments are ineffective.
⚖️ Efficacy:
- Metoclopramide:
Effective for a broader range of gastrointestinal-related nausea and vomiting due to its prokinetic effects. However, its efficacy may vary based on the underlying cause.
- Ondansetron:
Highly effective for nausea and vomiting induced by chemotherapy and surgery.
Its targeted action on serotonin receptors makes it very effective in these contexts.
🛡️ Side Effects:
- Metoclopramide:
Can cause extrapyramidal symptoms (such as tardive dyskinesia), drowsiness, fatigue, and diarrhea.
Long-term use can lead to more severe neurological side effects.
- Ondansetron: Generally well-tolerated, but can cause headaches, constipation, and dizziness.
It has a lower risk of severe side effects compared to metoclopramide.
🔒 Safety and Precautions:
- Metoclopramide:
Not recommended for long-term use due to the risk of serious side effects.
It should be used with caution in patients with a history of depression or Parkinson's disease.
- Ondansetron:
Considered safer for long-term use compared to metoclopramide. However, it should be used cautiously in patients with a history of heart rhythm disorders.
#PDFology
#Vs
#ابو_عبيدة 🇵🇸
Forwarded from Coursemia
Forwarded from PDFology (Basem Medhat)
Antibiotics by Dr Tarek AlMaqtari.pdf
5.1 MB
Forwarded from PDFology (Basem Medhat)
Pregnant women with otitis media give?
Anonymous Quiz
11%
Ciprofloxacin
8%
Levofloxacin
10%
Moxfloxacin
71%
Azithromyacin
Forwarded from PDFology (Basem Medhat)
Female sex hormones by Dr Tarek AlMaqtari.pdf
9.7 MB
Forwarded from Akib Ferdous
Thank you Mr Reda for the wonderful course. The exam was mostly from q posting and your amazing voice shots. Though the results are not out yet, I want to say I had an amazing journey with you and your team. Thank you. Really lucky to find a mentor like you.