The number of RBCs in severe cases equal to half of normal number

As the number of invaded RBCs decreases

cycles of parasite synchronized the quantity of pyrogen becomes sufficient to produce the characteristic chills and fever of malarial attack

P. vivax and P. ovale infect youngest erythrocytes,
while P. malariae infects the oldest one

invades erythrocytes of all ages

. In P. falciparum after 2-3 asexual cycles the number of infected RBCs reaches a dangerous threshold______
production of typical chills and fever

Erythrocytes containing_________ adhere to one another and to lining of blood vessels causing blockage of blood capillaries in vital area such as brain, lung, and kidney

Toxin production interferes with oxygen cause

Spleen is typically enlarged and congested ( splenomegaly), its color get darkened as amount of pigment________

Spleen hard in chronic stage and soft and hemorrhagic in acute stage

Bone marrow undergoes the same changes as__________ .

cause glomerulonephritis and pulmonary congestion

In Malarial paroxysm
P. vivax , P. ovale or quarter malaria characterized by sudden develops with shaking chill

The series of paroxysm constitute the primary attack complication and pericious symptoms: coma, convulsion, and cardiac failure

Microscopy:_________ blood films taken

___blood film for rapid examination of a large
volume of blood in small area on the slide
(concentration of parasite)

__ blood film for specific diagnosis of species

• Immunochromatographic methods to detect the _____ in blood

serology (detected _______) and PCR

Treatment of malarial attacks:

Resistant malaria P. falciparum showing drug resistant, and treated with quinine alone or with combination with other drugs