The zygotes in turn
become motile and elongated ( ookinetes ).

may persist as dormant forms, or hypnozoites

Resurgence of an erythrocytic infection (relapse) occurs when merozoites from hypnozoites in the liver break out

P vivax
infections lasting 40 years have been reported

Signs and symptoms are due to erythrocytic infection, not due to the Exo erythrocytic

Destruction of RBCs due to rupture and anemia

The number of RBCs in severe cases equal to half of normal number

As the number of invaded RBCs decreases

cycles of parasite synchronized the quantity of pyrogen becomes sufficient to produce the characteristic chills and fever of malarial attack

P. vivax and P. ovale infect youngest erythrocytes,
while P. malariae infects the oldest one

invades erythrocytes of all ages

. In P. falciparum after 2-3 asexual cycles the number of infected RBCs reaches a dangerous threshold______
production of typical chills and fever

Erythrocytes containing_________ adhere to one another and to lining of blood vessels causing blockage of blood capillaries in vital area such as brain, lung, and kidney

Toxin production interferes with oxygen cause

Spleen is typically enlarged and congested ( splenomegaly), its color get darkened as amount of pigment________

Spleen hard in chronic stage and soft and hemorrhagic in acute stage

Bone marrow undergoes the same changes as__________ .

cause glomerulonephritis and pulmonary congestion

In Malarial paroxysm
P. vivax , P. ovale or quarter malaria characterized by sudden develops with shaking chill

The series of paroxysm constitute the primary attack complication and pericious symptoms: coma, convulsion, and cardiac failure