Methylprednisolone itself is normally found in tablets.

The acetate ester is found in topical ointments and sterile aqueous suspensions
for intramuscular injection.

hydrolyzed to the active
methylprednisolone by the patient’s own systemic hydrolytic enzymes (esterases).

Protein may stay in solution, but many drugs will be bound to the serum proteins, albumin.

Protein binding can have a profound effect on

The placenta is able to block passage of proteins from maternal to fetal circulation

The drug–protein complex is too ________ to pass through the renal glomerular membranes, preventing rapid excretion of the drug.

_______ the effective concentration of warfarin at the receptor, leading to increase prothrombin time and potential hemorrhage

physiochemical properties of drugs, it must understand how drug transported, distributed, metabolised and excreted from the patient

Physicochemical Properties
• It refer to both physical and chemical properties of the drug molecule that may have an effect on its biological activity:
.

Drug molecules should have the required physicochemical properties.

In order to predict whether a drug will dissolve in water or in
lipid solvent, it must be determined whether the molecule and its functional groups can be bond to water or the lipid solvent molecules.

presence of ——- usually enhances water solubility.

lipid solubility is enhanced by nonionizable hydrocarbon chains and ring systems.

Neutral fat constitutes some 20% to 50% of body weight and constitutes a depot of considerable importance. Example: Thiopental

not all substances in the circulatory system, including drugs metabolites, and nutrients, will pass through the liver.

First pass effect”
-Proportion of the drug will be transported into the hepatocyte to inactive chemicals.