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Parenteral Administration
This type is better with:

• Place the drug directly into the circulating system

Subcutaneous and intramuscular injections
______ distribution of the drug

• Once in systemic circulation, the drug will undergo the _________ distributive phenomena as orally and intravenously administered agents before reaching the target receptor.

Intra spinal and intracerebral routes will place the drug indirectly into the spinal fluid or brain, respectively.

This bypasses a specialized epithelial tissue, the blood-brain barrier (BBB), which protects the brain from exposure to a large number of metabolites and chemicals.

(مهم حفظ ) Choice the correct answer

water-soluble sodium hemi succinate salt is used in oral, intravenous and intramuscular

Methylprednisolone itself is normally found in tablets.

The acetate ester is found in topical ointments and sterile aqueous suspensions
for intramuscular injection.

hydrolyzed to the active
methylprednisolone by the patient’s own systemic hydrolytic enzymes (esterases).

Protein may stay in solution, but many drugs will be bound to the serum proteins, albumin.

Protein binding can have a profound effect on

The placenta is able to block passage of proteins from maternal to fetal circulation

The drug–protein complex is too ________ to pass through the renal glomerular membranes, preventing rapid excretion of the drug.