What is the primary mechanism of action of eluxadoline?
Anonymous Quiz
15%
Selective 5-HT3 receptor antagonism
46%
Peripheral mu-opioid receptor agonism
0%
Anticholinergic muscarinic blockade
38%
Mixed mu-opioid agonist and delta-opioid antagonist
Maxemo EMREE 26-27
What is the primary mechanism of action of eluxadoline?
💡 EXPLANATION:
Eluxadoline treats IBS-D by reducing gut motility via mu-opioid agonism while limiting adverse effects through delta-opioid antagonism.
An elderly patient presents with splenomegaly, anemia, thrombocytopenia, low alkaline phosphatase, and a blood film showing granulocytes at all stages of maturation. This is most consistent with:
Anonymous Quiz
12%
Acute myeloid leukemia
6%
Leukemoid reaction
71%
Chronic myeloid leukemia
12%
Acute lymphoblastic leukemia
Maxemo EMREE 26-27
An elderly patient presents with splenomegaly, anemia, thrombocytopenia, low alkaline phosphatase, and a blood film showing granulocytes at all stages of maturation. This is most consistent with:
💡 EXPLANATION:
Granulocytes at all stages with splenomegaly and low LAP score are classic for chronic myeloid leukemia.
The underlying pathophysiology of systemic lupus erythematosus involves:
Anonymous Quiz
0%
Fibroblast activation and fibrosis
11%
Anti-CCP antibodies and synovial pannus
89%
Anti-nuclear antibodies and immune complex deposition
0%
IL-23 and IL-17 driven inflammation
Maxemo EMREE 26-27
The underlying pathophysiology of systemic lupus erythematosus involves:
💡 EXPLANATION:
SLE is a type III hypersensitivity disorder characterized by immune complex deposition from anti-nuclear antibodies.
What is the first-line treatment for a healthy 1-year-old with uncomplicated community-acquired pneumonia due to suspected Streptococcus pneumoniae?
Anonymous Quiz
27%
Azithromycin
50%
Amoxicillin
23%
Ceftriaxone
0%
Vancomycin
Maxemo EMREE 26-27
What is the first-line treatment for a healthy 1-year-old with uncomplicated community-acquired pneumonia due to suspected Streptococcus pneumoniae?
💡 EXPLANATION:
High-dose amoxicillin is the first-line treatment for uncomplicated pediatric CAP due to Streptococcus pneumoniae.
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A 58-year-old man with long-standing diabetes reports early satiety and vomiting of undigested food hours after meals. This is most likely due to:
Anonymous Quiz
0%
Nephropathy
90%
Gastroparesis
10%
Peripheral neuropathy
0%
Retinopathy
Maxemo EMREE 26-27
A 58-year-old man with long-standing diabetes reports early satiety and vomiting of undigested food hours after meals. This is most likely due to:
💡 EXPLANATION:
Autonomic neuropathy affecting the vagus nerve leads to delayed gastric emptying, known as diabetic gastroparesis.
A 58-year-old man presents with crushing chest pain and ECG shows ST elevation in leads V2 to V4. What is the most critical immediate medication?
Anonymous Quiz
13%
Intravenous nitroglycerin
80%
Chewed aspirin 325 mg
0%
Intravenous metoprolol
7%
Unfractionated heparin bolus
Maxemo EMREE 26-27
A 58-year-old man presents with crushing chest pain and ECG shows ST elevation in leads V2 to V4. What is the most critical immediate medication?
💡 EXPLANATION:
Aspirin provides immediate mortality benefit in acute STEMI by inhibiting platelet aggregation and limiting thrombus propagation.
65y M presents with sudden fever, chills, and rusty sputum. Vitals: T 39.5°C, HR 110, RR 24. Exam reveals RLL bronchial breathing. CXR shows RLL consolidation. Diagnosis is CAP requiring admission. What is the indicated initial antibiotic therapy?
Anonymous Quiz
30%
Amoxicillin PO
10%
Azithromycin IV monotherapy
50%
Ceftriaxone + Azithromycin
10%
Piperacillin-Tazobactam + Vancomycin
Maxemo EMREE 26-27
65y M presents with sudden fever, chills, and rusty sputum. Vitals: T 39.5°C, HR 110, RR 24. Exam reveals RLL bronchial breathing. CXR shows RLL consolidation. Diagnosis is CAP requiring admission. What is the indicated initial antibiotic therapy?
💡 EXPLANATION:
This patient has CAP requiring inpatient care (CURB-65 ≥2). Guidelines recommend combination therapy with a beta-lactam (e.g., Ceftriaxone) plus a macrolide (e.g., Azithromycin) for non-ICU inpatients to cover typical and atypical pathogens.
A 25-year-old male presents with sudden onset dyspnea and pleuritic chest pain. A chest X-ray is performed. Visualization of which specific line, representing the edge of the collapsed lung, confirms a pneumothorax?
Anonymous Quiz
30%
Parietal pleural line
40%
Kerley B line
10%
Mediastinal line
20%
Visceral pleural line