Which of following is most important tumour marker to diagnose carcinoma of ovary?

Mrs. Sandra got admitted to undergo lymph node biopsy. The investigation report states that there is no evidence of primary tumor and no regional lymph node and distant metastasis. The stage of her disease based on TNM classification is:-

Which of following is not a typical difference factor between benign and malignant tumors.

The severe weight loss accompanied by progressive weakness, loss of appetite and anemia that is usually associated with advanced cancer is called:-