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REPORTS AND SCIENTIFIC PUBLICATIONS
ON THE TOXICITY OF GRAPHENE OXIDE TO LIVING ORGANISMS AND TO HUMANS IN PARTICULAR

Graphene oxide generates thrombi: https://www.researchgate.net/publication/328338305_Graphene_Oxide_Touches_Blood_In_Vivo_Inter actions_of_Bio-Coronated_2D_Materials

Graphene oxide generates blood coagulation: http://vu2004.admin.hosting8.ing.udec.cl/Proyectos/investigacion-con-grafeno-con- aplicaciones- hemostaticas/

Toxicity of graphene-family nanoparticles: a general review of origins and mechanisms. https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-016- 0168-y

Toxicity of graphene in human sperm: https://francis.naukas.com/2016/08/21/toxicidad-del-grafeno-y-los-nanotubos-de- carbono-en-el- esperma-humano/

The dangers of graphene and its side effects on human biology: https://computerhoy.com/noticias/hardware/peligros-del-grafeno-sus- efectos-secundarios-12591
Graphene nanomaterials: synthesis, biocompatibility and cytotoxicity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274822/

Nanotoxicology: Breathing carbon nanotubes causes pulmonary fibrosis, a cause of lung cancer: https://francis.naukas.com/2009/10/29/nanotoxicologia-respirar-nanotubos-de- carbono-produce- fibrosis-pulmonar-una-causa-de-cancer-de-pulmon/

Safety assessment of graphene-based materials: Focus on human health and the environment: https://pubs.acs.org/doi/10.1021/acsnano.8b04758#

Graphene oxide is detected in the body by specialized cells of the immune system causing the same symptomatology as the alleged "SARSCOV2":
https://www.graphene- info.com/graphene-oxide-detected-body-specialized-cells-immune-system

Toxicity of graphene in normal human lung cells: https://pubmed.ncbi.nlm.nih.gov/21485826/

Can nanomaterials induce reproductive toxicity in male mammals?: https://www.sciencedirect.com/science/article/abs/pii/S0048969720378852

Graphene oxide affects the outcome of in vitro fertilization by interacting with the sperm membrane in an animal model: https://www.sciencedirect.com/science/article/pii/S0008622317312757#undfig1

Effects of Nano-Graphene Oxide on Testis, Epididymis and Fertility of Wistar Rats: https://www.researchgate.net/publication/315776736_Effects_of_Nano- Graphene_Oxide_on_Testis_Epididymis_and_Fertility_of_Wistar_Rats

Graphene oxide nano- biointeraction induces inhibition of spermatogenesis and alteration of fatty acid metabolism in the nematode Caenorhabditis elegans: https://pubmed.ncbi.nlm.nih.gov/30218681/

Graphene oxide touches the blood: in vivo interactions of “bio-coronated” 2D materials: https://pubs.rsc.org/en/content/articlelanding/2019/nh/c8nh00318a#!divAbstract

Toxicity of graphene in human sperm and consequences: https://francis.naukas.com/2016/08/21/toxicidad-del-grafeno-y-los-nanotubos-de- carbono-en-el- esperma-humano/

Graphene oxide can induce mutagenesis (cancer), in vitro and in vivo: https://www.nature.com/articles/srep03469

Repeated exposure to aerosolized graphene oxide mediates autophagy inhibition and inflammation in a three-dimensional human airway model: https://www.sciencedirect.com/science/article/pii/S2590006420300107?via%3Dihub #fig5

Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model: https://www.sciencedirect.com/science/article/pii/S0008622318304706?via%3Dihub #undfig1

Physicochemical properties based on differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated by oxidative stress: https://www.nature.com/articles/srep39548

An assessment of the cytotoxic effects of graphene nanoparticles on the epithelial cells of the human lungs: https://journals.sagepub.com/doi/10.1177/0748233718817180

Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.2877

Graphene nanoparticles induce ap optosis in MCF-7 cells through mitochondrial damage and NF- KB pathway:
https://iopscience.iop.org/article/10.1088/2053-1591/ab33af

Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish: https://link.springer.com/article/10.1007/s11426-012-4620-z

An in vitro cytotoxicity assessment of graphene nanosheets on alveolar cells: https://www.sciencedirect.com/science/article/abs/pii/S0169433217335109?via%3Di hub

Graphene nanosheets damage lysosomal and mitochondrial membranes and induce the apoptosis of RBL-2H3 cells: https://www.sciencedirect.com/science/article/abs/pii/S0048969720327467?via%3Di hub

Genotoxicity of graphene nanoribbons in human mesenchymal stem cells: https://www.sciencedirect.com/science/article/abs/pii/S0008622312009499?via%3Di hub

Differential genotoxic and epigenotoxic effects of graphene family nanomaterials (GFNs) in human bronchial epithelial cells: https://www.sciencedirect.
com/science/article/abs/pii/S1383571816300262?via%3Di hub

A closer look at the genotoxicity of graphene based materials: https://iopscience.iop.org/article/10.1088/2515-7639/ab5844

DNA Melting and Genotoxicity induced by silver nanoparticles and grapehene: https://pubs.acs.org/doi/10.1021/acs.chemrestox.5b00052

Hydroxylated-graphene quantum dots induce DNA damage and disrupt microtubule structure in human esophageal epithelial cells: https://academic.oup.com/toxsci/article/164/1/339/4970755

Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo: https://www.sciencedirect.com/science/article/abs/pii/S0045653517309517?via%3Dihub

Genotoxic response and damage recovery of macrophages to graphene quantum dots: https://www.sciencedirect.com/science/article/abs/pii/S0048969719304073?via%3Dihub

Can graphene quantum dots cause DNA damage in cells?: https://pubs.rsc.org/en/content/articlelanding/2015/NR/C5NR01734C

Blood exposure to graphene oxide may cause anaphylactic death in non-human primates: https://www.sciencedirect.com/science/article/pii/S1748013220300918?via%3Dihub

Cellular and molecular mechanistic insight into the DNA-damaging potential of few-layer graphene in human primary endothelial cells: https://www.sciencedirect.com/science/article/abs/pii/S1549963416000848?via%3Dihub

Impact of graphene oxide on human placental trophoblast viability, functionality and barrier integrity:
https://iopscience.iop.org/article/10.1088/2053-1583/aab9e2

PEGylation of reduced graphene oxide induces toxicity in cells of the blood–brain barrier: an in vitro and in vivo study:
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.6b00696

Oxygen content-related DNA damage of graphene oxide on human retinal pigment epithelium cells:
https://link.springer.com/article/10.1007%2Fs10856-021-06491-0

Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma- derived PC12 cells:
https://pubs.acs.org/doi/10.1021/nn1007176

Evaluation of graphene oxide induced cellular toxicity and transcriptome analysis in human embryonic kidney cells:
https://www.mdpi.com/2079-4991/9/7/969

Toxicology study of single-walled carbon nanotubes and reduced graphene oxide in human spermatozoa:
https://www.nature.com/articles/srep30270

Dose-dependent effects of nanoscale graphene oxide on reproduction capability of mammals: https://www.sciencedirect.com/science/article/abs/pii/S0008622315301366?via%3Di hub

Short-term in vivo exposure to graphene oxide can cause damage to the gut and testis: https://www.sciencedirect.com/science/article/abs/pii/S0304389417300171?via%3Di hub

Cyto and genotoxicities of graphene oxide and reduced graphene oxide sheets on spermatozoa: https://pubs.rsc.org/en/content/articlelanding/2014/RA/c4ra01047g

Potential adverse effects of nanoparticles on the reproductive system: https://www.dovepress.com/potential-adverse-effects-of- nanoparticles-on-the-reproductive-system- peer-reviewed-fulltext-article-IJN

Assessment of the toxic potential of graphene family nanomaterials: https://www.sciencedirect.com/science/article/pii/S1021949814000106?via%3Dihub

Nanotoxicity of Graphene and Graphene Oxide: https://pubs.acs.org/doi/10.1021/tx400385x

Graphene toxicity as a double-edged sword of risks and exploitable opportunities: a critical analysis of the most recent trends and developments. https://iopscience.iop.org/article/10.1088/2053- 1583/aa5476

A differential effect of graphene oxide on the production of proinflammatory cytokines: https://www.worldscientific.com/doi/abs/10.1142/S1682648515500110

Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells: https://www.sciencedirect.com/science/article/pii/S0304389421011225?via%3Dihub

Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice:
https://www.nature.com/articles/am20137
A review of toxicity studies on graphene-based nanomaterials in laboratory animals: https://www.sciencedirect.com/science/article/abs/pii/S0273230017300119?via%3Di hub

Neutrophils degrade graphene oxide, mediated by myeloperoxidase: https://www.researchgate.net/publication/351888431_Neutrophils_Defensively_Degrade_Graphene_O xide_in_a_Lateral_Dimension_Dependent_Manner_through_Two_ Distinct_Myeloperoxidase_Mediated_Mechanisms

Expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations: http://europepmc.org/article/MED/24854092

Remote control of the cardiac activity of a living being using graphene: https://www.infosalus.com/asistencia/noticia-manejan-celulas- cardiacas-cultivadas-laboratorio- control-remoto-20180522073436.html

Graphene oxide, administered intramuscularly, accumulates in the lungs, causing pulmonary toxicity and death by granuloma:
https://link.springer.com/article/10.1557/jmr.2017.388

rGO (reduced graphene oxide) provokes a host-viral response in the immune system as if it were a pathogen: https://www.sciencedirect.com/science/article/abs/pii/S0142961213012088

Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy: https://www.sciencedirect.com/science/article/abs/pii/S1742706116304810

Cellular and molecular mechanistic insight into the DNA-damaging potential of few-layer graphene in human primary endothelial cells: https://www.sciencedirect.com/science/article/abs/pii/S1549963416000848

Multiple effects of graphene oxide toxicity in interaction with mammalian cells. https://www.sciencedirect.com/science/article/pii/S0169409X16302411#f0025

Toxicity Evaluation of Graphene Oxide in Kidneys: https://pubmed.ncbi.nlm.nih.gov/27043588/

Toxicology of carbon nanotubes and fullerenes: https://copro.com.ar/Toxicologia_de_los_fullerenos.html

The puzzling potential of carbon nanomaterials: general properties, application, and toxicity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466546/

Synthesis and toxicity of graphene oxide nanoparticles: a literature review of in vitro and in vivo studies:
https://www.hindawi.com/journals/bmri/2021/5518999/

Radio-frequency characteristics of graphene oxide: https://aip.scitation.org/doi/abs/10.1063/1.3506468
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https://twitter.com/disclosetv/status/1574005954244485121
A human enzyme can biodegrade graphene

https://www.sciencedaily.com/releases/2018/08/180823113613.htm

Degradation of Single-Layer and Few-Layer Graphene by Neutrophil Myeloperoxidase

https://onlinelibrary.wiley.com/doi/10.1002/anie.201806906

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