اهم حاجات ف anti cancer📌

⭐ Doxorubicin → Irreversible cardiomyopathy
⭐ Doxorubicin → CCNS
⭐ Vincristine → M phase
⭐ Vinca alkaloids → Inhibit tubulin polymerization
⭐ Paclitaxel → Promotes tubulin polymerization
⭐ Alkylating agents → DNA cross-links
⭐ Methotrexate → Folinic acid rescue
⭐ Antimetabolites → Folate/Purine/Pyrimidine analogues
⭐ Anastrozole → ↓ Estrogen synthesis (Aromatase inhibitor)
⭐ Fulvestrant → Estrogen receptor antagonist
⭐ Erlotinib & Gefitinib → EGFR tyrosine kinase inhibitors
⭐ Immune checkpoints → CTLA-4, PD-1, PD-L1
⭐ Neoadjuvant chemotherapy → Before surgery
⭐ Combination therapy → Different mechanisms + Different toxicities
⭐ Drug resistance → Drug efflux (P-glycoprotein)