path_exam_QA.pdf
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هذا ملف لكويز الباثو
النص الاول اسئلة واتية
النص الثاني اجابتهم
تقدروا تقروا منه و تختبروا منه انفسكم💯
#PT342
النص الاول اسئلة واتية
النص الثاني اجابتهم
تقدروا تقروا منه و تختبروا منه انفسكم💯
#PT342
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RA Treatment Algorithm
Step 1
Early RA (<6 months)
➡ Methotrexate alone
Step 2
Moderate disease
➡ Double or Triple therapy
Examples:
MTX + Sulfasalazine
MTX + Hydroxychloroquine
MTX + Leflunomide
Step 3
Moderate-Severe RA not responding to synthetic DMARDs
➡ Add TNF inhibitor
Example:
Adalimumab
Infliximab
Etanercept
Step 4
Failure of TNF inhibitor
➡ Rituximab
OR
➡ Abatacept
Step 1
Early RA (<6 months)
➡ Methotrexate alone
Step 2
Moderate disease
➡ Double or Triple therapy
Examples:
MTX + Sulfasalazine
MTX + Hydroxychloroquine
MTX + Leflunomide
Step 3
Moderate-Severe RA not responding to synthetic DMARDs
➡ Add TNF inhibitor
Example:
Adalimumab
Infliximab
Etanercept
Step 4
Failure of TNF inhibitor
➡ Rituximab
OR
➡ Abatacept
❤3
RA 🦴
Best initial DMARD = Methotrexate
MTX onset = 3–6 weeks
Folic acid reduces MTX toxicity
Anti-CCP = most specific test
Hydroxychloroquine is safest in pregnancy
MTX + Leflunomide = teratogenic
TNF inhibitors reactivate TB
Rituximab = Anti-CD20
Abatacept blocks T-cell activation
NSAIDs relieve symptoms only; do not prevent progression.
Best initial DMARD = Methotrexate
MTX onset = 3–6 weeks
Folic acid reduces MTX toxicity
Anti-CCP = most specific test
Hydroxychloroquine is safest in pregnancy
MTX + Leflunomide = teratogenic
TNF inhibitors reactivate TB
Rituximab = Anti-CD20
Abatacept blocks T-cell activation
NSAIDs relieve symptoms only; do not prevent progression.
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