General Anesthetics
Halothane — Hepatotoxicity
Nitrous oxide — Diffusion hypoxia
Ketamine — Hallucinations
Propofol — Hypotension
Thiopental — Respiratory depression
Halothane — Hepatotoxicity
Nitrous oxide — Diffusion hypoxia
Ketamine — Hallucinations
Propofol — Hypotension
Thiopental — Respiratory depression
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Local Anesthetics Exam favorites 📌
• Cocaine → vasoconstriction (NOT dilation)
• Esters → more allergy
• Amides → more toxicity
• Acidic tissue → ↓ LA effect
• Adrenaline → NOT in fingers/toes
• Lidocaine → standard drug / anti arrhythmic
• Bupivacaine → long + cardiotoxic
• Prilocaine → blood problem (metHb)
• Benzocaine → surface only
• Procaine → allergy / slow
• Cocaine → vasoconstriction (NOT dilation)
• Esters → more allergy
• Amides → more toxicity
• Acidic tissue → ↓ LA effect
• Adrenaline → NOT in fingers/toes
• Lidocaine → standard drug / anti arrhythmic
• Bupivacaine → long + cardiotoxic
• Prilocaine → blood problem (metHb)
• Benzocaine → surface only
• Procaine → allergy / slow
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OPIOIDS ‼️
• “Morphine: miosis + constipation + retention”NOT urination
• “Methadone = long acting withdrawal control”✔️ addiction treatment
• “Meperidine = seizures” ⚠️ anticholinergic effect
• Naloxone does NOT treat withdrawal
• Morphine ❌ NOT for head injury ✔️ Crosses placenta
• Opioids ❌ NOT anti-inflammatory
• Buprenorphine ❌ not easily reversed ✔️ sublingual
• Codeine ❌ not addiction-free
Tramadol = Inhibits 5-HT & NE reuptake
(cancer patients) → give laxative
• “Morphine: miosis + constipation + retention”NOT urination
• “Methadone = long acting withdrawal control”✔️ addiction treatment
• “Meperidine = seizures” ⚠️ anticholinergic effect
• Naloxone does NOT treat withdrawal
• Morphine ❌ NOT for head injury ✔️ Crosses placenta
• Opioids ❌ NOT anti-inflammatory
• Buprenorphine ❌ not easily reversed ✔️ sublingual
• Codeine ❌ not addiction-free
Tramadol = Inhibits 5-HT & NE reuptake
(cancer patients) → give laxative
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Local Anesthetics ✅
Non-ionized form → crosses membrane ✔️
• Alkaline pH → ↑ effect ✔️
Bupivacaine = heart danger ⛔️
Prilocaine = metHb
Benzocaine = topical only
Amides = ❗ More systemic toxicity
Procaine = NOT used topically ❗
Articaine = both amide + ester bond ❗
Procaine = allergy
Non-ionized form → crosses membrane ✔️
• Alkaline pH → ↑ effect ✔️
Bupivacaine = heart danger ⛔️
Prilocaine = metHb
Benzocaine = topical only
Amides = ❗ More systemic toxicity
Procaine = NOT used topically ❗
Articaine = both amide + ester bond ❗
Procaine = allergy
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