We just published v3.3b1, which is a beta version for the inline bot API. Please check the attached example, and the Telegram Bot API resources.
Example: https://github.com/python-telegram-bot/python-telegram-bot/blob/inlinebots/examples/inlinebot.py

New stable release v3.3! It features

- Inline bots
- Send any file by URL
- Specialized exceptions: Unauthorized, InvalidToken, NetworkError and TimedOut
- Integration for botan.io (thanks to @ollmer)
- HTML Parsemode (thanks to @jlmadurga)
- Bugfixes and under-the-hood improvements

**Very special thanks to Noam Meltzer (@tsnoam) for all of his work!**

New stable release v3.4! It features

- Move Updater, Dispatcher and JobQueue to new telegram.ext submodule (thanks to @rahiel)
- Add disable_notification parameter (thanks to @aidarbiktimirov)
- Fix bug where commands sent by Telegram Web client would not be recognized (thanks to @shelomentsevd)
- Add option to skip old updates on bot startup
- Send files from BufferedReader

Released 4.0rc1

- Implement Bot API 2.0
- Almost complete recode of Dispatcher
- Please read the Transition Guide to 4.0: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Transistion-guide-to-Version-4.0

To install, use pip install python-telegram-bot==4.0rc1
Please note: This release is not backwards compatible to 3.4

We also have a small website now: https://python-telegram-bot.org/

Released v4.0.1

- Implement Bot API 2.0
- Almost complete recode of Dispatcher
- Please read the Transition Guide to 4.0
- Changes from 4.0rc1
- The syntax of filters for MessageHandler (upper/lower cases)
- Handler groups are now identified by int only, and ordered
- Note: v4.0 has been skipped due to a PyPi accident

Transition guide: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Transition-guide-to-Version-4.0

Update to latest version:
pip install -U python-telegram-bot

Released 4.0.2

- Bugfixes
- KeyboardReplyMarkup now accepts str again

Update with pip install -U python-telegram-bot

Released 4.0.3

- Add missing attribute location to InlineQuery

We couldn't find 4.0.4 to release this time, releasing 4.1 instead. 😉

Released 4.1

- Implement API changes from May 6, 2016
- Fix bug when start_polling with clean=True
- Methods now have snake_case equivalent, for example telegram.Bot.send_message is the same as telegram.Bot.sendMessage

Released v4.1.1
This release fixes the Deprecation warning caused by Dispatcher using two newly deprecated (mostly internally used) methods 😁

We are currently considering dropping Python 2.6 support. Would you mind answering this quick poll? https://www.strawpoll.me/10227996

Released v4.1.2

This is a fix release for a critical bug due to Bot API 2.1 changes, where getUpdates would fail.
Please update immediately:
pip install -U python-telegram-bot

Released v4.2

- Implement Bot API 2.1
- Move botan module to telegram.contrib
- New exception type: BadRequest

Also, we have a small tutorial now: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Extensions-%E2%80%93-Your-first-Bot

Update to latest version with pip install -U python-telegram-bot

PS: We're already working on v5.0, featuring an improved JobQueue and better Emoji support.

Released v4.2.1

Minor bug fixes:

- Fix CallbackQuery.to_dict() bug (thanks to jlmadurga)
- Fix editMessageText exception when receiving a CallbackQuery

Update to latest version:
$ pip install -U python-telegram-bot

Released v4.3

- Use urllib3.PoolManager for connection re-use
- Rewrite run_async decorator to re-use threads
- New requirements: urllib3 and certifi

This release significantly improves performance, so we decided to release it separetely from v5.0, which is coming during the next weeks.

We just released a fix release v4.3.1, because v4.3 had a wrong version of urllib3 as minimum requirement.

Please also check out our new wiki articles!

Webhooks: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Webhooks

Hosting a bot at baum.xyz: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Hosting-a-bot-at-baum.xyz

Another fix release, v4.3.2, was just published.

The timeout parameter is now respected again in all telegram.Bot methods.

Update to latest version:
$ pip install -U python-telegram-bot

The just released v4.3.3 brings back proxy support that was removed with the switch to urllib3 in the v4.3 release.

New major release v5.0

- Rework JobQueue
- Introduce ConversationHandler
- Add telegram.constants module

There's also a small guide to help you with the transition: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Transition-guide-to-Version-5.0

We want to keep a list of projects that are related to python-telegram-bot in some way.
If you are developing such a project, please add it to this list: https://github.com/python-telegram-bot/python-telegram-bot/wiki/Related-Projects

To our friends in Brazil, check out this great tutorial by Júlia Rizza:
https://juliarizza.wordpress.com/2016/08/06/fazendo-um-bot-para-telegram-em-python/