Solutions ✅⬇️

APC gene testing is the first step in screening for familial adenomatous polyposis syndrome in children because it can be diagnosed by more than 100 colonic polyps.
Starting at age 10, a flexible sigmoidoscopy or colonoscopy is performed annually if the screening results are positive.
The relative's risk of acquiring colorectal cancer is comparable to the general population if the APC test results are negative. The screening can be started at age 50.

Solutions ✅⬇️

Most likely, the patient has Peutz-Jeghers syndrome.
It is distinguished by darkening of the buccal mucosa, lips, and digits as well as hamartomatous polyps of the gastrointestinal system (most frequently the small intestine).
The patient in the clinical example experienced an intestinal intussusception.
In Peutz-Jeghers syndrome, the many polyps frequently act as a lead point.

Solutions ✅⬇️

The patient's family history, the provided image of a pigmented retina, and the APC gene mutation all point to familial adenomatous polyposis.
Instead of 15, the APC gene, which is situated on the long arm of chromosome 5 (5q21), is the cause of familial adenomatous polyposis.

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