Selank - The Stress-Proof Brain Peptide

In our constantly connected, high-stimulus world, cognitive performance under stress has become the ultimate competitive advantage. Enter Selank, a peptide developed by Russian researchers that might be the ultimate brain-protective compound for our modern lifestyle.

Unlike traditional anti-anxiety medications that often come with brain fog or decreased alertness, Selank operates through a fascinating mechanism: it stabilizes enkephalins (the body's natural anxiety-regulating compounds) while simultaneously promoting nerve growth factor. The result? Reduced stress and anxiety paired with enhanced cognitive clarity—the holy grail of modern performance.

What makes Selank particularly relevant for research is its ability to protect cognitive function during periods of intense stress or sleep deprivation. Research subjects (RS) show maintained focus and emotional stability during high-pressure situations, improved memory retention, and enhanced verbal fluidity.

Some RS even describe it as "stress-proofing" the brain—allowing them to process emotionally charged situations with the calm clarity typically achieved only through years of meditation practice. In a world that's constantly demanding more from our cognitive resources, Selank represents a fascinating tool for maintaining peak mental performance even when life cranks up the pressure!

Potential Side Effects: Research indicates possible mild drowsiness initially, headaches, changes in blood pressure, and allergic reactions. Due to effects on neurotransmitters, caution is advised regarding potential interactions with psychiatric medications or pre-existing mental health conditions.

Medical Disclaimer: This information is for educational purposes only. This peptide is not FDA-approved for human use. Always consult with a licensed healthcare provider before considering any peptide therapies. This post does not constitute medical advice.

SELANK
https://collabs.shop/eovszd

Use code PRIMALSAM for 10% off your retail-price order!

*Research peptides are for research use only, and not specified for human, animal, or in-vivo use only.

Now that my Tirz research supply is getting lower, I have been considering a full swap to Reta for my research.

Goals are to break this long weight stall and further support blood sugar and inflammation.

Currently I research 2.5mg Tirz on Fri + 3mg Reta on Mon.

This post is perfect timing and encouraging!

Would you consider switching your RS to Reta from Tirz?

https://huntershealthhacks.beehiiv.com/p/transitioning-from-tirz-to-reta

B7-33 Peptide as a Potential Therapeutic for Fibrosis: new research paper!

Discover the potential of B7-33, a synthetic peptide derived from the hormone relaxin, in combating fibrosis and promoting tissue health.

This groundbreaking research highlights B7-33's ability to selectively activate the RXFP1 receptor, reducing excessive collagen buildup and inflammation.

Its anti-fibrotic properties make it a promising candidate for conditions like heart failure, kidney disease, and even scleroderma.

🧬 Key Highlights:

Targets RXFP1 receptor for anti-fibrotic and anti-inflammatory effects.

Promotes collagen breakdown through MMP2 activation.

Potential applications in managing fibrotic disorders.

📖 Read the Full Research Paper: https://docs.google.com/document/d/1aeBFFVIm-42q-Q0pSB0-DhSe5C_AtnSafjbrxgI2O6Q/edit?usp=sharing

⚠️ Disclaimer: The information shared here is for educational purposes only and should not be considered medical advice. Always consult with a trusted healthcare professional before starting any new treatments, supplements, or peptides.

B7-33 2mg
https://www.uk-peptides.com/b7-33-2mg?tracking=RjDZyOcUnzqB2K6E8a92YMMUhNknCHnzHMv5ubqPNIzZwZXbX7BuyROPWLBbgZg5

*Research use only. Not for use in humans or animals.

My RS tried everything: every diet, every workout, even seeking help from an integrative naturopath specializing in feminine hormones. Yet, nothing fully worked, and the weight always came back.

That feeling of being trapped inside the body while doing all the right things? My research subject lived in that space for years. It wasn’t until I uncovered what was missing in my RS’s unique puzzle that I finally found the breakthrough I needed.

By gently incorporating some science—while staying true to the primal diet and quantum factors—I broke through what felt like an impossible wall. This journey wasn’t just about shedding pounds; it was about supporting my RS from the inside out.

Now, I've created something to help other researchers embark on their own transformative journey: my 📚 FREE Peptides for Weight Loss Guide! 📚
https://www.dropbox.com/scl/fo/61smc6u28i42uk2urg9iz/ACDLzUhrDHompUMa0cD2-OI?rlkey=g3l6t08pl0srquxk3eoh4wro4&st=d7iuqv8a&dl=0

It’s packed with everything I wish I’d had bundled into one resource from the start—honest insights about side effects, microdosing tips, and the non-negotiables that made the difference for my research. I also share my personal research story.

This guide isn’t about quick fixes or one-size-fits-all solutions. It’s about empowering you to understand YOUR subject and get the research support you need after all your hard work. By the end, you’ll feel equipped to break free from weight loss frustrations and find the confidence your RS deserves.

✨What’s Inside✨
💉 What Are Peptides?
💉 My Personal Journey with Peptides
💉 GLP-1s and GLP-1-like Peptides for Weight Loss
💉 Benefits Beyond Weight Loss
💉 Common Side Effects
💉 Non-GLP-1 Weight Loss Peptides
💉 How to Reconstitute Peptides for Accurate Dosing
💉 Dosing: Nano vs Micro vs Mini vs Standard
💉 How to Inject Peptides Subcutaneously
💉 Popular Peptides for Other Purposes
💉 Non-Negotiables with Peptides

Ready to transform your research and finally reach those goals?

🌟 Download your FREE guide here: https://www.dropbox.com/scl/fo/61smc6u28i42uk2urg9iz/ACDLzUhrDHompUMa0cD2-OI?rlkey=g3l6t08pl0srquxk3eoh4wro4&st=d7iuqv8a&dl=0

Is Your Environment Making You Gain Weight? All About Obesogens

Ever wondered why your weight-loss efforts seem to hit a wall despite your best intentions? The answer might be hiding in your kitchen containers, not your kitchen cabinets.

⚖️ What Are Obesogens?
These troublesome chemicals in our environment can interfere with your body's natural hormone balance and potentially contribute to weight gain. Think of them as uninvited guests affecting your metabolism.

💔 Obesogens can:
Disrupt your metabolic processes
Alter your hormonal balance
Encourage your body to create more fat cells

☣️ Where Are These Obesogens Hiding?
These problematic compounds are surprisingly common in our daily lives:
Plastic food containers (especially when heated)
Processed foods with certain additives
Non-stick cookware
Personal care products
Pesticides on conventional produce

Your Action Plan: Reducing Obesogen Exposure

🧴 Beauty & Home Improvements
Choose personal care products free of parabens and phthalates
Switch to natural cleaning products for healthier indoor air
Invest in a quality water filter to reduce chemical exposure

👩‍🍳 Food & Kitchen Makeover
Replace plastic containers with glass or stainless steel alternatives
Choose fresh, whole foods over processed options when possible
Use 100% PURE ceramic cookware instead of non-stick pans
*Save 20% sitewide this weekend + get a free mini skillet on $275+ thru 3/30 with my code: PRIMALSAM (affiliate): https://xtrema.sjv.io/APmjJR

🌞 Body Support
Stay well-hydrated to support your body's natural detoxification
Incorporate nutrient-rich, antioxidant-supportive foods
Prioritize quality sleep and effective stress management

Remember, small changes add up! Which of these changes might you try first?

OPTIMIZED MITOCHONDRIA: Your Secret Weapon Against Advanced Aging, Weight Gain & Hormone Chaos

Let's talk about why those tiny energy factories in your cells are EVERYTHING when it comes to how you feel, look, & function.

Think of your mitochondria as the power plants running EVERY process in your body. When they're sluggish, it's like trying to charge your phone with a broken charger – you'll never reach 100%!

Here's what's actually happening when your mitochondria are struggling:
-Your metabolism s-l-o-w-s down because cells can't efficiently burn fat for fuel (hello stubborn weight!)
-Hormone production goes haywire (your body prioritizes survival over optimal function)
-Your skin cells can't regenerate quickly (premature wrinkles & dullness appear)
-Energy production tanks (that bone-deep fatigue isn't laziness – it's cellular)
-Inflammation skyrockets (triggering autoimmune flares)

When my condition was at its worst, I would literally fall asleep sitting up at my desk. My skin looked dull, weight kept creeping up, & my hormone panel looked like it belonged to someone 30 years older. Sound familiar?

The game-changer? Supporting those tiny cellular powerhouses instead of just masking symptoms. The research is clear: a single brain cell uses BILLIONS of ATP molecules every second! No wonder we feel so drained when our mitochondria aren't functioning optimally.

Here's my protocol to help optimize mitochondria function & reclaim energy & vitality:
*Always ask your doctor first before starting anything new!*

☀️ Sunshine Therapy
• Daily sun exposure (without sunscreen) for 5-20 minutes outside peak hours (start slow)
• This triggers mitochondrial melatonin production - a POWERFUL antioxidant!
• WARNING: If you've been consuming seed oils regularly, wait 6 months after eliminating them before LONGER sun exposure. The linoleic acid stored in tissues makes you burn like crazy!

🧪 Cutting-Edge Peptide Research
• Scientists are studying MOTS-c peptide for mitochondrial support
• This mitochondrial-derived peptide shows promise for metabolic regulation
• Can also present as an exercise mimetic
• Check out this fascinating research: translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-03885-2

💊 Professional-Grade Support
• CellCore BC-ATP is my go-to for clients needing serious mitochondrial support
• Only available through practitioners (raises hand!) & you can use my code to access this special supplement: CFsGrwBK
• Start slow! In clinical practice, BC-ATP is generally well-tolerated by sensitive patients & can help improve protocol tolerance, but still powerful. cellcore.com/products/bc-atp

⚡️ NAD+ Boost
• Niacinamide supplement. Ask your doc if 50 mg three times daily is right for you.
• Supports mitochondrial energy production pathways
• Enables proper cellular cleanup & renewal
• Nerd out on NAD+ for mitochondria inside this study: pmc.ncbi.nlm.nih.gov/articles/PMC4963347/

🧹 Environmental Toxin Detox
• Replace plastic food containers with glass
• Ditch chemical cleaners for simple vinegar/baking soda alternatives
• Create an EMF-free sleep sanctuary (at minimum: devices OFF or airplane mode!)
• Remember: these toxins directly disrupt your endocrine system and mitochondria!

🥩🥑 Ancestral Eating Blueprint
• Eliminate ALL seed oils (soybean, canola, corn, sunflower, safflower)
• Replace with animal fats like grass-fed butter, tallow, ghee
• Focus on seasonal produce + collagen-rich proteins
• Optimize carbs from produce & white rice (if tolerated) instead of eliminating them (carbs are important for mitochondrial function!)
• Bookmark free ancestral recipes from my blog archives here: primalsam.com/category/recipes/
• Need quality protein sources? I love Butcher Box delivery for clean, humanely raised meats + they always have a great deal for new members: (affiliate) butcherbox.pxf.io/N9QaMP

This protocol works from the INSIDE OUT. Instead of band-aid solutions, these steps can actually rebuild cellular infrastructure!

XX, Sam
*Not medical advice

MOTS-c
https://collabs.shop/9oaynn

Use code PRIMALSAM for 10% off your retail-price order!

*Research peptides are for research use only, and not specified for human, animal, or in-vivo use only.

NAD+
https://collabs.shop/efhzdm

Use code PRIMALSAM for 10% off your order!

*Research peptides are for research use only, and not specified for human, animal, or in-vivo use only.

TFW your morning run does the opposite
*Especially with cortisol issues

🏃‍♀️ So let's talk about something that might be blowing your mind right now... that morning run you're KILLING yourself to wake up for? It might actually be working AGAINST your weight loss goals, especially if you have cortisol issues or autoimmunity.

Here's what's actually happening: 🤯

→ When you have autoimmune disease or adrenal issues, intense cardio can spike your cortisol (that pesky stress hormone) even HIGHER than it already is.

→ And what does cortisol loves to do? Store fat, especially around your middle, and mess with your hormone and thyroid function.

→ Then you're exhausted but wired, craving sugar by 3pm, can't sleep even though you're tired, and the scale won't budge despite your perfect diet.

🌤 What if instead, you could:

• Wake up feeling ACTUALLY rested (not just caffeine-ready)

• Exercise in a way that SUPPORTS your hormones instead of draining them

• Watch inflammation melt away (goodbye puffy face!)

• Feel energized ALL day (not just the first hour after coffee)

I'm not saying throw away your running shoes! I'm saying we need to work WITH your body, not against it (ie, those are your lovely walking shoes now, honey). 👟👟

Want to know exactly how I restructured my workout routine to support my own fatigued adrenals + Hashimoto's?

📰💖 I've got all the details in this archive blog post where I break down the science and what can work instead:

https://tinyurl.com/46ds852m

Your body is trying to recover - let's stop fighting it and start working with it.

*Not medical advice.

Cagrilintide: An Exciting New Approach to Weight Management
Recent research on cagrilintide is showing promising results for weight management through a different mechanism than GLP-1 agonists. Here's what you should know:

What is Cagrilintide?
Cagrilintide is a long-acting amylin analog that mimics the hormone amylin, which works alongside insulin to regulate glucose metabolism and appetite. Unlike GLP-1 agonists (semaglutide, tirzepatide), cagrilintide targets the amylin receptor pathway.

Key Benefits:
Reduces hunger and food cravings
Promotes satiety (feeling of fullness)
Slows gastric emptying
Can complement GLP-1 therapy through different mechanism

How It Differs from GLP-1 Medications:
While GLP-1s like Ozempic and Wegovy work by targeting GLP-1 receptors to reduce appetite and slow digestion, cagrilintide works through the amylin pathway. The key difference:
GLP-1s: Impact insulin secretion and blood glucose directly
Cagrilintide: Primarily focuses on appetite regulation without direct blood glucose effects

Clinical Trial Results:
Cagrilintide Alone: Phase 2 trials showed dose-dependent weight loss of up to 10.8% at highest doses over 26 weeks
Combined with Semaglutide: The combination therapy showed enhanced weight loss compared to either medication alone
REDEFINE (rx brand name of Cagri + Sema combined) Phase 3 Trial: Combining weekly cagrilintide with semaglutide demonstrated significantly greater weight reduction than semaglutide alone

Common Side Effects:
Fatigue (most commonly reported)
Nausea
Injection site reactions
Constipation
Reduced appetite (intended effect)

Microdosing Approach to Minimize Side Effects:
Subjects report success with peptides with a microdosing strategy:
Start with very small doses (much lower than standard)
Gradually increase dose over extended period *if tolerated and necessary
Allow body to adjust more slowly to reduce fatigue and GI symptoms
Ensure adequate hydration and electrolyte balance

This represents a significant advance in weight management medications, offering a new pathway that can work alone or synergistically with existing GLP-1 therapies.

CAGRI is ON SALE! Save $30/vial.

Eligible for further multi-vial pricing at this discount, and stackable with my discount code PRIMALSAM

https://polarispeptides.com/product/cagrilintide-5mg/

*Research peptides are for research use only, and not specified for human, animal, or in-vivo use only.

Hi tribe! 👋 Just a reminder that posting outside sources of research materials goes against channel guidelines.

I keep an eye out for these posts so there is no circulation of potentially harmful products, as well as to protect the time I put into creating content and research for our channel.

These types of posts will be deleted to protect the channel, and the user will be removed.

Thanks so much for choosing to learn with me about peptides, and please let me know if you have any questions at all!

xx
Sam

Ever been so tired of fighting your own body that you just wave the white flag? 🏳️

There I was, staring at yet another unflattering photo (you know the kind), wondering if "accepting" my metabolic malfunction fate was really the answer.

Spoiler alert: it wasn't. My body was SCREAMING for help.

My energy? Nonexistent.
My weight? Stubborn as that stain on your favorite shirt.
My libido? We were no longer on speaking terms.
My mood? I avoided my family so I didn’t snap over small crap.
My confidence? A sad and wrinkly deflated birthday balloon.

I decided "acceptance" wasn't going to cut it anymore. I couldn't live like this anymore.

Here's exactly how I flipped the script:

I completely revolutionized my approach to hormones and inflammation. Instead of just "dealing with it," I got strategic with ancestral wisdom plus modern science (because why choose just one?).

The transformation wasn't just about the number on the scale (though hello, jeans that fit again! 👖). It was waking up ACTUALLY feeling rested. Having energy past 2pm. Feeling again like that woman who used to laugh, feel sexy, and not want to bite someone's head off over tiny inconveniences.

Which sounds more like you?
-"I've tried everything and nothing works"
-"My doctor says my labs are normal but I feel TERRIBLE"
-"I'm so tired of being tired"
-“Specialists gave up on me.”

If you're nodding yes, I've got something for you: a method to reclaim your energy, waistlines, and zest for life, all by using my uncensored approaches to hormonal health.

Want the unfiltered protocol? Stay tuned for my next post for the simplified version of the steps I added the last two years that made ALL the difference.

P.S. Remember that unflattering jeans photo I mentioned? It's now my "before" pic. What would YOUR "before" pic be?

🔥 THE UNCENSORED PROTOCOL: What ACTUALLY Worked for My Subject When Nothing Else Did 🔥

Welcome to the no-BS zone! Here's the FULL protocol that mainstream medicine doesn't want you talking about:
(Psst: Stay tuned for later this week where I’ll be dropping a downloadable checklist to help you implement this above protocol in your own research! )

1️⃣ Dual GLP-1 Support
• My research subject used low-dose, bi-weekly GLP-1 (two different formulations, Reta and Tirz) with INCREDIBLE results.
• Not just for weight - for inflammation markers too!
👉 Download my Free Quick Start Guide: Peptides for Weight Loss HERE:
https://t.me/primalpeps/484

2️⃣ Mitochondrial Resurrection
• Modern research subjects’ cellular powerhouses are DYING. Here's how to put that into reverse:
• MOTS-c peptide support
• Microdosing cycle strategy 3x / year makes this affordable and gentle - get my free Microdosing Magic Guide here: https://www.dropbox.com/scl/fo/e2zv3bex32q3madg95ab1/AJ8Zm4t_RV-CFD5HiCvQEec?rlkey=h8xe8l9al3r78s6rr3b4a7l1d&st=udki53rr&dl=0
• Learn more about MOTS-c here (research use only) and save on your first order of research materials: https://polarispeptides.com/product/mots-c-10mg/nebula/primalsam/ - use code PRIMALSAM to save 10%
• nnEMF awareness and mitigation steps (game changer!)
• Turn off wifi at night
• Ethernet cable
• Phone and electronics out of bedroom
• Red Light Therapy - 15 min daily transformed my energy
👉 My favorite RLT mat is the flexible Thera Tri-Lite - use code PRIMALSAM to save 10%
https://therasage.com/products/single-red-light-panel?rfsn=7881394.971241&variant=31128343248980&utm_source=refersion&utm_medium=affiliate&utm_campaign=7881394.971241

3️⃣ True Hydration (not just "drinking water")
• Standard water = basically useless without minerals and with fluoride added
• Added specific minerals to filtered water based on HTMA testing
• My personal mineral cocktail was extra sodium, potassium, molybdenum.
• Get checked here (not affiliated, just in love with their service and pricing): https://www.optimalhealthnetwork.com/Hair-Tissue-Mineral-Analysis-HTMA-p/ohchtma.htm
• My fave general tonic for remineralizing water: Concentrace Trace Mineral Drops - Glass Bottle - by Trace Minerals Research.
• Access my dispensary and get 25% off ongoing: https://us.fullscript.com/welcome/steague

4️⃣ Hormone Optimization (the REAL secret)
• THIS was the true turning point! Nothing compares to:
• INJECTABLE Testosterone (creams, pellets, troches just don't cut it as well)
• Bioidentical estradiol + progesterone in perfect balance Result: Complete body recomposition, energy surge, libido BACK
• Paloma can help with HRT (thyroid, estrogen, progesterone) except Testosterone https://app.palomahealth.com/referral/PRIMALSAM
• Regenics may be able to help qualifying women with Testosterone https://regenics.com/?ref=8252

5️⃣ Strategic Protein Protocol
• Less than fitness influencers recommend.
• More than USDA says you need.
• Focus on ANIMAL protein sources for bioavailability, supplementing with non-soy, non-legume sources as needed (ie, nuts and seeds)
👉 FREE Quick Protein Bites Guide: https://t.me/primalpeps/60
👉 My family gets our meat from Butcher Box (MRNA-free promise, antibiotic-free, hormone-free) - use my link for FREE protein for a year (I will earn a small commission if you purchase through my affiliate link): https://butcherbox.pxf.io/N9QaMP

6️⃣ Circadian Rhythm Repair
• The foundation everything else builds on:
• Morning sunlight exposure (non-negotiable!)
• Meal timing aligned with cortisol rhythm
• Evening red light + blue light blocking
👉 FREE QUANTUM SUPPORT GUIDE: https://www.dropbox.com/scl/fo/fqe0hqdesoxpnpebfqb5e/AJTbHlolAmsQUcM5JgSbRq8?rlkey=ehz02bdxggbnhe0ncb2pedujc&st=lguwoq8a&dl=0
👉 These high quality Bon Charge blue blockers clip onto any glasses: https://boncharge.com/products/clip-on-blue-light-blocking-glasses?rfsn=8520396.5606126 + use PRIMALSAM for 15% off

Your Body Isn't Broken - It's Just Speaking a Language No One Taught You to Understand

How deep have you fallen into the "why am I still not feeling better?" spiral despite trying ALL. THE. THINGS?

I used to be that person with 37 different supplements cluttering my counter but no actual PLAN. Sound familiar? 😏

My targeted supplement plans aren't random collections - they're precisely formulated to address specific issues with FEWER supplements than you're probably taking now.

Plus, each plan comes with a FREE mini module!

Choose your own adventure:

🦋 Thyroid Support + free Quantum Thyroid Bundle (thyroid optimization that doesn't require a medical degree) 🔗 tinyurl.com/mrydwz79

⚖️ GLP-1 Support + Weight Loss Quick Start Bundle (for sustainable results that don't involve crying into kale leaves) 🔗 tinyurl.com/yuh2cxws

🦠 Standard Viral Protocol + free Viral Infections Module - One of the most common underlying conditions making your progress stuck is reactivated EBV and over 90% of people are affected! 🔗 tinyurl.com/3vmeys6c

Imagine waking up and actually WANTING to bound out of bed instead of hitting snooze 6 times. Picture opening your closet and feeling excited about what to wear instead of dreading how things will fit. Think about having the mental clarity to be fully present instead of nodding along while your brain feels like it's swimming through fog. That's not a fantasy - that's what happens when you finally address what's REALLY going on!

This isn't just about supplements – it's about reclaiming the version of you that's been hiding under those symptoms.

⏰ Take 25% my full dispensary: us.fullscript.com/welcome/steague