Non Big Pharma approaches with peptides that have shown potential in different ways within cancer research:

*Not medical advice. Research, studies, and hypotheses only.*

PNC27 targets and disrupts cancer cell membranes, leading to cell death.

AICAR activates AMP-activated protein kinase (AMPK), which inhibits the mTOR pathway, leading to cell cycle arrest and apoptosis in cancer cells.

P21 is a cyclin-dependent kinase inhibitor that can induce cell cycle arrest and apoptosis in cancer cells.

LL37 has antimicrobial properties and can induce apoptosis in cancer cells, making it a potential therapeutic agent.

Hexarelin Acetate shows promise in modulating immune responses and potentially targeting cancer cells, though research is still ongoing.

https://pubmed.ncbi.nlm.nih.gov/20080680/

https://www.sciencedirect.com/science/article/pii/S0021925820591710

https://pmc.ncbi.nlm.nih.gov/articles/PMC6826572/

https://www.nature.com/articles/s41598-024-71946-7

https://www.mdpi.com/1422-0067/24/2/993

📝 Round 2 of HRT, but with a fresh strategy: switching from T cream to injections and adding estrogen tablets this time, and adding back P capsules. Because sometimes we need to pivot until we find what works.

Lab results don't lie... and after 9 years of LOW-LOW hormone levels (despite reducing inflammation and thyroid antibodies), I'm choosing to work smarter, not harder.

👩‍🔬 Here's the science drop:

✔️ When progesterone shows up at menopausal levels (<20) and this is combined with symptoms of adrenal fatigue, it could mean your adrenals are stealing from your hormone bank to make cortisol.
✔️Think of it like your body taking an emergency loan to handle stress.
✔️This could explain why my adrenals are again overly sensitive and in overdrive despite all the recovery work.

👀 More insight:
Low hormones can lead to low energy, weight gain, and advanced aging.

At 44, with perimenopause knocking, I'm expanding my hormone support toolkit. Some days I struggle with needing more support - shouldn't my body handle this naturally? Other days I'm completely at peace with doing whatever it takes to feel alive again.

🔎 Both lenses come in and out of focus, and that's okay.

Quality of life isn't about doing it alone - it's about doing what works.

Drop a 💊 if you've ever felt conflicted about needing medication/supplements, or share your hormone journey below. Let's normalize this conversation!

*Not medical advice.

I hope everyone has a lovely Christmas tomorrow if you celebrate! Happy Holidays from my family to yours!

Lipo-C Fat Loss and Metabolism Injections: NEW Research Paper Alert!

🔍 Curious about innovative ways to boost weight loss, burn fat, enhance metabolism, and support liver health? Our latest research paper covers all these aspects in detail!

💬 This simple provides you with practical insights and actionable steps to achieve your subject's wellness goals.

💉 Lipo-C is can significantly improve weight management, fat loss, energy, and metabolic health...all without being a peptide! It can be a great addition / stack to your current research.

💡 Ready to level up your research? Access the full research paper here and start implementing these proven methods in your testing today: https://docs.google.com/document/d/14mDCLOGTe0l78QIu4-70Wavca_48r8bPiVYtglzizvU/edit?usp=sharing

XX,
Sam

Raise your hand if you went a little overboard with the Christmas cookies! (It's me, I'm raising my hand. 🙋‍♀️)

No shame, no guilt - here's my gentle bounce-back plan that loves on your body while staying true to your wellness goals!


My "Day After Too Many [insert your holiday indulgence here] 😅" reset:

🍋 Morning kickstart: Lemon water + decaf fatty collagen coffee, no sweetener (gets things "moving," IFYWIM!)

💉 Lypoh-Cee vitamin/mineral blend for liver love and gentle detox boost. Learn more about its fat loss and metabolism benefits here: https://t.me/primalpeps/412

🍳 Breakfast: 4 eggs with roasted root veggies (hello, stable blood sugar from fat, protein, and slow-burn carbs!)

🥤 Snack attack? Sparkling water + handful of dry-roasted nuts -or- beef jerky

🍖 Lunch: Big juicy burger with mustard + crunchy carrot sticks

☕️ Afternoon pick-me-up: Another fatty collagen coffee because self-care.

🍠 Dinner: Keeping it easy and cozy with leftover Christmas ham + mashed sweet potato


Why this works?

The protein + healthy fats help regulate blood sugar, while the minerals and whole foods can naturally support my body's own detox systems.

Plus, zero guilt means zero stress hormones!

Remember: One day of treats doesn't derail your journey. Your body knows exactly what to do - just give it some extra TLC! 💕

Who else needs this today? Drop a 🎄 below!

LIPO Extreme - Research use only.

*Suggested as a B12-free option to their Lipo-C, which uncharacteristically includes B12.

https://solutionpeptides.net/product/new-product-lipo-extreme-500mg/ref/primalsam/

Save 15% with my discount code! PRIMALSAM15

I can’t even understand my own handwriting. Maybe I should have pursued a doctorate after all. 🤣📝

Currently deciphering my notes from the podcast I listened to this morning hosted by @nuvitruwellness featuring @modernthyroid about testosterone. *Both @'s are on IG.

Will share once I translate my own writing to English! 🙈

🙄 "Just eat less & move more" -Said every gym bro who's never experienced hormone chaos from PCOS, endo, & thyroid disease!

Fun fact: When you're battling chronic illness, that "simple" advice can actually wreck your hormones even MORE. Been there, tried that, got the burnout to prove it!

Ready for something that actually works? I've put together two quick guides that can help you break through those frustrating plateaus.

Whether you're dealing with:

• Stubborn fatigue
• Sleep issues
• Insulin resistance
• Weight loss stalls

These guides works alongside your research to support your body's natural biology and wellness abilities. And since I'm updating it for 2025 soon, I want you to grab the current versions now!

Snag your free copies here: https://www.dropbox.com/scl/fo/fqe0hqdesoxpnpebfqb5e/AJTbHlolAmsQUcM5JgSbRq8?rlkey=ehz02bdxggbnhe0ncb2pedujc&st=zjktwn9s&dl=0

Remember: Your body isn't broken - it just needs the right approach!

Snag your free copies here: https://www.dropbox.com/scl/fo/fqe0hqdesoxpnpebfqb5e/AJTbHlolAmsQUcM5JgSbRq8?rlkey=ehz02bdxggbnhe0ncb2pedujc&st=zjktwn9s&dl=0

New Year's Eve "shots" looking a lot different! 🧪

Happy last day of 2024, hun.

🙏 I hope you reached or reached for goals you set out to achieve.
🙏 I hope you rediscovered pieces of yourself that had gotten lost amid your wellness journey.
🙏 I hope you continue to love yourself in 2025 even more than you loved yourself in 2024.

I'm grateful to be a part of your community and I'm grateful that you are part of mine.

Without our connections we would not be where we are today with our wellness…

We save each other Every. Damn. Day. 🤜🤛

And I stand by that belief because we are proof that self-advocacy works!

Happy New Year!!

#hashimotos #autoimmunehealth #womenshealth #reverseaging #guthealth #inflammation #functionalmedicine #naturopathy #selfadvocacy #wellnessjourney #2025goals #newyearwellness #biohacking #autoimmunecommunity #thyroidhealth #antiaging #integrativewellness #ancestralhealth #primalhealth #wellnesswarrior #immunehealth #naturalmedicine

🌿 Let's talk about that shiny "New Year, New You" energy that has you going ALL IN... only to burn out by February.

Here's a wild thought: What if we took it down a notch and vibed with our biology instead?

Your ancestors didn't crush 5am HIIT classes or meal prep 27 identical containers.

They just... lived. Moved their bodies. Ate real food. Slept when it got dark.

Radical idea: Start with tiny, sustainable tweaks that feel good:

* Catch some morning sunlight
* Move a little more naturally
* Eat actual food you enjoy
* Get decent sleep
* Touch grass (literally)

The secret to lasting change? Working with your body, not against it.

Ready to get primal... but make it modern? 😏

https://primalsam.com/transform-your-health-this-year-with-a-primal-reset/

🌅🦁🥑

Truth bomb: Without tuning into our body's quantum nature and embracing joy, our wellness and weight goals become an uphill battle. We end up fighting against our own biology instead of flowing with it.

✨ Your body is a magnificent quantum ecosystem that thrives on joy! Science shows us that positive emotions literally light up our cells.

When you laugh, dance, or simply breathe in fresh morning air, you're not just feeling good - you're optimizing your body's natural intelligence.

Remember: Your wellness and weight journey isn't about restriction - it's about expansion. Expand your joy. Expand your awareness. Expand into the fullness of life.

Take a moment today to do something that makes your heart sing. Your cells are listening. Your body will thank you with sustainable, lasting changes that actually feel good. 🌱✨

🚨 There's Hope For Your Metabolism (Even With Fatigue)

Struggling with fatigue + weight that won't budge? I discovered 4 gentle ways to support your metabolism that actually work (even when you can barely get out of bed).

👉 No intense workouts
👉 No restrictive diets
👉 Works WITH your tired body

As someone with Hashimoto's who could barely function, I get it. The usual advice feels impossible when you're exhausted.

That's why I'm sharing exactly how I:
✨ Stabilized my energy without crazy workouts
✨ Supported my metabolism while honoring my fatigue
✨ Found tools that actually helped

And the best part? You can start where you are, even on your worst days.

🔍 Discover all 4 metabolism-supporting strategies (that work even when you're exhausted):

https://primalsam.com/4-ways-to-support-metabolism-when-you-have-fatigue/

Working on a little something for y'all! Getting so close to being done!

🔬 Let's talk testosterone, ladies…

I organized my hand written notes from a podcast featuring PA McPhereson, and let me tell you - we need to chat about the "T" word!

Here's the T tea: Conventional medicine often acts like testosterone is just "for the boys" but…

NEWSFLASH - women make testosterone too! And when our levels drop, it's no picnic. 🎢

My scribbled research shows how integrative & functional medicine is finally giving women's testosterone the attention it deserves! Because guess what? When our T is low, we might experience:

• That "meh" feeling about intimacy 😴
• Stubborn weight that won't budge 😤
• Energy levels in the basement 🔋
• Mood swings that make us question everything 🎭
• Muscle strength? What muscle strength? 💪

The hormone cascade is real, hun! When our adrenals are stressed, progesterone drops, and that can lead to low T. It's all connected!

The good news? There are options! From strength training 🏋️‍♀️ to proper hormone testing to comprehensive adrenal support - we've got tools in our toolkit.

Here are my translated notes from the podcast if you're interested:

Reference Ranges & Symptoms:
• Symptoms: fatigue, hair loss, libido, depression
• Conservative approach to optimal women's T levels: between 30-50 on labs

Hormonal Cascade:
• Adrenal fatigue → Low progesterone
• Low progesterone → Low testosterone
• Low T → Reduced libido & exercise capacity

Treatment Considerations:
• Strength training important for hormone balance
• "All in" adrenal support needed
• Check if estrogen is high

Key Monitoring:
• Regular lab work needed to assess levels during T therapy
• Consider a progressive approach to dosing (dosing amounts not mentioned)

*Important note: These are just my personal research notes from the podcast - not medical advice! Always work with a qualified healthcare provider for your unique situation.

PODCAST: Creating Healthy Testosterone Levels; McCall McPherson - https://nuvitruwellness.com/episode-92-testosterone/

Testosterone is an important hormone in both men and women. McCall and Lahana Vigilano go over everything you’d want to know about testosterone (and let me mention, McCall is an AMAZING practitioner!). She answers questions like:

What testosterone does for our body
Symptoms of high or low testosterone
How our lifestyle effects this hormone level
Ideal functional medicine ranges in testosterone (NOT the normal reference ranges most doctors use)
How we can raise it
How we can lower it

Doing “all the things” wasn’t enough to completely fix my chronic issues…

• I bought the organic mattress to avoid chemical off-gassing
• I drove to the co-ops for pastured meat and eggs to avoid grain-fed animal proteins
• I set my subscribe & save to toxin-free skincare to avoid endocrine disruptors
• I did the ozone IVs for EBV
• I tried fecal microbiota transplantations for my depleted microbiome
• I got Maya massage for my endometriosis and PCOS
...and So. Much. More.

And while I know that these topics are so important….

Obsessing over every little toxin didn’t give me my gallbladder back.

Since loss of gallbladder can lead to ongoing hormone imbalance (thyroid, stress, and sex hormones) and ongoing chronic fatigue… I predict I’ll need ongoing added support (beyond low toxin living) from peptides, supplements, and nootropics.

For life. 👵

Here’s what I’ve learned in my decade of biohacking:

1) Sometimes we need to pause the endless quest for external solutions and dig deeper…internally.

2) While finding root causes is crucial, it’s okay to take breaks along the way.

3) When “doing all the things” isn’t working, it might be time to shift our focus to the deeper issues at hand.

4) Recovery isn’t linear. Literally. Like I felt amazing last week and this week I feel like arse. It comes and goes!

Remember: Your journey isn’t a checklist – it’s a conversation with your body. 💞

Everyone’s path to addressing weight gain and low energy is different... but the right symptom support can make all the difference.

How Long Do Peptides Last?
Hint: A LOT longer than you think
*by Hunter Williams

"I came across a study recently that recently caught my attention.

Researchers found that over 90% of more than 100 prescription and over-the-counter drugs remain effective up to 15 YEARS beyond their expiration date. Crazy, right?
But thinking about it, maybe it shouldn’t be that surprising.

As consumers, we’re almost trained to throw things away at the slightest sign of expiration:

• Clothes get tossed with minor wear.
• Food is thrown out when it hits that magical “expiration date.”
• Medications and supplements are often discarded even if they’re still perfectly good.

The truth is, most of this “expiration anxiety” is just wasteful, and it’s costing us.

Now, let’s talk peptides.

Many people hesitate to make large peptide purchases because they worry about them “going bad.” But with the proper storage, peptides can actually last a lot longer than you might expect.

Here’s what you need to know:

Storage Basics

• Lyophilized (freeze-dried) peptides – which is how most peptides are sold – are actually pretty stable. If stored in a cool, dark place, they can remain potent in the fridge for at least 1-2 years without any issues.
• Reconstituted peptides (when you’ve mixed them with bacteriostatic water) are a bit more delicate. They’ll usually remain potent in the fridge for 4-8 weeks. After that, they may gradually lose some effectiveness, but they’re far from “spoiled” the moment a month has passed.

But should you freeze them?
NO! Here’s why:

• Risk of Moisture Absorption: Lyophilized peptides are hygroscopic, meaning they can easily absorb moisture from the air. Freezing can cause condensation inside the vial, introducing moisture, especially during freeze-thaw cycles. Moisture can start the degradation process even before the peptide is reconstituted.
• Structural Integrity: Freezing can create ice crystals within the peptide powder, which may disrupt the peptide's delicate structure. This is especially true if the peptide has complex or sensitive molecular structures, leading to degradation or loss of function.
• Unnecessary Stress: Lyophilized peptides are typically stable at room temperature (in a dry, dark place) for extended periods.
• Batch Variability: Freezing could introduce inconsistent results, especially if different vials experience varying moisture levels or structural damage over time, which could impact the peptide’s overall stability.

Does this mean your peptides are toast if you put them in the freezer?
Not necessarily.

Technically, they might not be ruined because lyophilized peptides are in a stable, freeze-dried state designed to withstand low temperatures.

As long as moisture didn’t enter the vial and they were not subjected to repeated freeze-thaw cycles, their structure and potency are likely preserved.

But I would recommend NOT freezing your peptides at any point in the future."

FULL POST:
https://huntershealthhacks.beehiiv.com/p/how-long-do-peptides-last?_bhlid=f40813aaf780d5d3b668907d39c264288f29544a&utm_campaign=how-long-do-peptides-last&utm_medium=newsletter&utm_source=huntershealthhacks.beehiiv.com

🥘 Raise your hand if you've ever felt personally victimized by a "cozy" winter meal that left you feeling like you needed a 3-hour nap! 🙋‍♀️

Listen, as someone who's battled Hashimoto's, I know the struggle of wanting those warm, comforting bowls of foodstuffs...but without the inflammatory aftermath.

That's why I'm sharing this game-changing "pozole" verde recipe that's totally grain and nightshade-free (but still tastes like a warm hug in a big mug!)

Bonus: it's packed with protein and nutrients that support your metabolism and keep you satisfied for hours - no more sneaking back to the kitchen for those late-night snacks! 😉

📑 I've also included methods in the recipe notes section so that you can adapt it to other ancestral diets.

Ready to enjoy winter comfort food without the bloat, brain fog, and joint pain? Grab my free recipe and join the "I can actually eat winter comfort food without regret" club!

➡️ Get cozy: primalsam.com/primal-corn-free-pozole-verde/

*Image enhanced with AI assistance. *Not medical advice.

I'm re-sharing this research document about peptides for MCAS because my RS has been struggling with histamine issues recently.

This is very likely due to methylation/MTHFR mutation acting buggery again from an overload of B12 triggering overmethylation. I started working on a blog post about this phenomenon, as well as a low histamine resource, but they both need more work and references before I'm comfortable publishing either. ❤️

For now, here is "Mast Cell Activation Syndrome (MCAS) Support!"

Looks like KPV is getting added to my cart! 😉

https://docs.google.com/document/d/1P8rk1IX3RLRIHeUaqWghGAXw5ffNQ5c6ptqer_y7DHg/edit?usp=sharing