-Paracetamol is a para-aminophenol derivative, it is a non-Opioid non salicylate. It has analgesic, antipyretic properties and weak anti-inflammatory Activity.
-Paracetamol produces central and peripheral analgesia by elevation of the pain threshold and inhibition of prostaglandin biosynthesis, and antipyretic action through the effect on the hypothalamic heat-regulating center, resulting in peripheral vasodilatation, increased blood flow through the skin, sweating and heat loss.
-Paracetamol is readily absorbed from the gastro-intestinal tract with beak plasma concentertion occurring about 10 to 60 minutes after oral administration.
-Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk .
-Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged Paracetamol .
-The elemination half-life of Paracetamol varies form about 1to3hours.
-Caffeine is absorbed readily after oral does and is widely distributed in the body. It is also absorbed through the skin.
-Caffeine passes realily in to the CNS. Low concentrations are also present in breast milk.
-Caffeine is metabolised almost Completely in the liver and exereted in urine.
-The elimination half- life of Caffeine are about 3 to 7 hours
-Paracetamol produces central and peripheral analgesia by elevation of the pain threshold and inhibition of prostaglandin biosynthesis, and antipyretic action through the effect on the hypothalamic heat-regulating center, resulting in peripheral vasodilatation, increased blood flow through the skin, sweating and heat loss.
-Paracetamol is readily absorbed from the gastro-intestinal tract with beak plasma concentertion occurring about 10 to 60 minutes after oral administration.
-Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk .
-Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged Paracetamol .
-The elemination half-life of Paracetamol varies form about 1to3hours.
-Caffeine is absorbed readily after oral does and is widely distributed in the body. It is also absorbed through the skin.
-Caffeine passes realily in to the CNS. Low concentrations are also present in breast milk.
-Caffeine is metabolised almost Completely in the liver and exereted in urine.
-The elimination half- life of Caffeine are about 3 to 7 hours
DOSAGE AND ADMINISTRATION
-Paradol® Extra Tablets are suitable for adults and children over 12 years of age :- two tablets up to four times a day.
-Not recommended for children under 12 years.
-If necessary the dose may be repeated every four hours but do not take more than four doses in 24 hours
-Paradol® Extra Tablets are suitable for adults and children over 12 years of age :- two tablets up to four times a day.
-Not recommended for children under 12 years.
-If necessary the dose may be repeated every four hours but do not take more than four doses in 24 hours
PREGNANCY AND LACTATION
-Although there is epidemiological evidence of the safety of Paracetamol in pregnancy and lactation, medical advice should be sought before using this product
-Although there is epidemiological evidence of the safety of Paracetamol in pregnancy and lactation, medical advice should be sought before using this product
Type of drugs
* Each film coated caplet of Paradol® Cold & Flu contains: Paracetamol 500 mg Pseudoephedrine Hcl 30 mg Chlorpheniramine maleate 2 mg
#-Pseudoephedrine Hcl is a sympathomimtic agent, for sympathomimtic relief from nasal congestion.
#-Chlorpheniramine maleate is an alkylamin derivative, it is a sedating antihistamine that causes a moderate degree of sedation it also has antimuscarinic activity.
#-Chlorpheniramine maleate is an alkylamin derivative, it is a sedating antihistamine that causes a moderate degree of sedation it also has antimuscarinic activity.
-Paradol® Cold & Flu should not be used during breast feeding as there may be risks associated with use of antihistamines in infants.