PREGNANCY AND LACTATION
Meclozine may be excreted in breast milk and it may be inhibit lactation due to its antimuscarinic action
Meclozine may be excreted in breast milk and it may be inhibit lactation due to its antimuscarinic action
-Paracetamol is a para-aminophenol derivative, it is a non-Opioid non salicylate. It has analgesic, antipyretic properties and weak anti-inflammatory Activity.
-Paracetamol produces central and peripheral analgesia by elevation of the pain threshold and inhibition of prostaglandin biosynthesis, and antipyretic action through the effect on the hypothalamic heat-regulating center, resulting in peripheral vasodilatation, increased blood flow through the skin, sweating and heat loss.
-Paracetamol is readily absorbed from the gastro-intestinal tract with beak plasma concentertion occurring about 10 to 60 minutes after oral administration.
-Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk .
-Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged Paracetamol .
-The elemination half-life of Paracetamol varies form about 1to3hours.
-Caffeine is absorbed readily after oral does and is widely distributed in the body. It is also absorbed through the skin.
-Caffeine passes realily in to the CNS. Low concentrations are also present in breast milk.
-Caffeine is metabolised almost Completely in the liver and exereted in urine.
-The elimination half- life of Caffeine are about 3 to 7 hours
-Paracetamol produces central and peripheral analgesia by elevation of the pain threshold and inhibition of prostaglandin biosynthesis, and antipyretic action through the effect on the hypothalamic heat-regulating center, resulting in peripheral vasodilatation, increased blood flow through the skin, sweating and heat loss.
-Paracetamol is readily absorbed from the gastro-intestinal tract with beak plasma concentertion occurring about 10 to 60 minutes after oral administration.
-Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk .
-Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged Paracetamol .
-The elemination half-life of Paracetamol varies form about 1to3hours.
-Caffeine is absorbed readily after oral does and is widely distributed in the body. It is also absorbed through the skin.
-Caffeine passes realily in to the CNS. Low concentrations are also present in breast milk.
-Caffeine is metabolised almost Completely in the liver and exereted in urine.
-The elimination half- life of Caffeine are about 3 to 7 hours
DOSAGE AND ADMINISTRATION
-Paradol® Extra Tablets are suitable for adults and children over 12 years of age :- two tablets up to four times a day.
-Not recommended for children under 12 years.
-If necessary the dose may be repeated every four hours but do not take more than four doses in 24 hours
-Paradol® Extra Tablets are suitable for adults and children over 12 years of age :- two tablets up to four times a day.
-Not recommended for children under 12 years.
-If necessary the dose may be repeated every four hours but do not take more than four doses in 24 hours
PREGNANCY AND LACTATION
-Although there is epidemiological evidence of the safety of Paracetamol in pregnancy and lactation, medical advice should be sought before using this product
-Although there is epidemiological evidence of the safety of Paracetamol in pregnancy and lactation, medical advice should be sought before using this product
Type of drugs
* Each film coated caplet of Paradol® Cold & Flu contains: Paracetamol 500 mg Pseudoephedrine Hcl 30 mg Chlorpheniramine maleate 2 mg
#-Pseudoephedrine Hcl is a sympathomimtic agent, for sympathomimtic relief from nasal congestion.
#-Chlorpheniramine maleate is an alkylamin derivative, it is a sedating antihistamine that causes a moderate degree of sedation it also has antimuscarinic activity.
#-Chlorpheniramine maleate is an alkylamin derivative, it is a sedating antihistamine that causes a moderate degree of sedation it also has antimuscarinic activity.
-Paradol® Cold & Flu should not be used during breast feeding as there may be risks associated with use of antihistamines in infants.