DOC-20230221-WA0012..pdf
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المحاضرة الثانية عقاقير
Pyridine –piperidine-pyrolidine alkaloids
Pyridine –piperidine-pyrolidine alkaloids
❤4
Biosynthesis of pyridine - pyrolidine alkaloids
-من اسمه يعني يحوي على كل من
-pyridine
حلقة سداسية غير مشبعه
-pyrolidine
حلقة خماسية
الجزء الاساسي هو ornithine
اما جزء المساعد هو metionine نحصل منه ch3
⛔️ ينتج النه من اندماج كل من
Ornithine (حامض اميني)
+
Nicotine
في الtobacco
🔅هذه الاندماج يكون symmetric متماثل
⛔️ شنو الوسيط الرأيسي بهل انتاج؟
N-methyl pyrolidinium ion
حيث يحدث عملية electrophilic substitution في الكاربونه رقم 3 من حلقة الpyridine للNicotinic acid
-من اسمه يعني يحوي على كل من
-pyridine
حلقة سداسية غير مشبعه
-pyrolidine
حلقة خماسية
الجزء الاساسي هو ornithine
اما جزء المساعد هو metionine نحصل منه ch3
⛔️ ينتج النه من اندماج كل من
Ornithine (حامض اميني)
+
Nicotine
في الtobacco
🔅هذه الاندماج يكون symmetric متماثل
⛔️ شنو الوسيط الرأيسي بهل انتاج؟
N-methyl pyrolidinium ion
حيث يحدث عملية electrophilic substitution في الكاربونه رقم 3 من حلقة الpyridine للNicotinic acid
❤9
The important alkaloid in indian tobacco is
Anonymous Quiz
4%
A) morphine
56%
B)lobeline
41%
C)nicotine
0%
D)ephidrine
👍1
Derivatives of piperidine
Anonymous Quiz
69%
A)lobeline
7%
B)ornithine
1%
C) asparatine
23%
D) all above
The family of lobelia inflate is
Anonymous Quiz
6%
A. Solanaceae
88%
B. Lobeliaceae
1%
C. Asteraceae
5%
D. Umbellifareae
Nicotine is biosynthesized from
Anonymous Quiz
36%
A).ornithine
10%
B).aspartic acid
2%
C) glyceraldehyde.
48%
D) all above
5%
E) none above
🎉1🫡1
Lobeline used by the Native Americans for
Anonymous Quiz
3%
A)asthma
2%
B)chronic bronchistis
49%
C) respiratory stimulant
45%
D)all above
❤1
Upon reduction, the tertiary base pyridine is converted into the
Anonymous Quiz
13%
A. Pyrolidine
79%
B. Piperidine
2%
C. Ornithine
6%
D. Nicotine
Lobelia plant is
Anonymous Quiz
5%
A)drived bark &tops
12%
B)drived roots&tops
74%
C)drived leaves &tops
9%
D)none above
All the followings are correct for nicotine except: -
Anonymous Quiz
6%
A.Obtained from the leaves of Nicotiana tobacco fam Solanaceae (Major)
6%
B.Liquid colorless alkaloid
5%
C.Gangelioleptic with a cardiovascular effect and increases blood pressure
56%
D.Biosynthetically derived from aspartic acid and lysine
28%
E. It is not carcinogenic
nicotine is derivatives of
Anonymous Quiz
15%
A) nicotinic acid
5%
B) pyridine
3%
C) piperidine
3%
D) pyrolidine
74%
E) both b&d
_________ is the key intermediate in biosynthesis of nicotine
Anonymous Quiz
18%
A. Ornithine
2%
B. Nicotinic acid
68%
C. N- methylpyrrolinium ion
12%
D. N-methylputrescine
nicotine has pronounced
effects on the cardiovascular system, where peripheral vasoconstriction, atrial tachycardia ............. are observed.
effects on the cardiovascular system, where peripheral vasoconstriction, atrial tachycardia ............. are observed.
Anonymous Quiz
5%
A) an increase diastolic blood pressure
3%
B)an increase systolic blood pressure
9%
C)decrease in both systolic & diastolic blood pressure
83%
D)an increase in both systolic & diastolic blood pressure
The important alkaloids in pyridine and piperidine
Anonymous Quiz
14%
A)Nicotine, morphine, Arecoline, Lobeline
62%
B) Nicotine, Coniine, Arecoline, Lobeline
14%
C)Nicotine, atropine, Arecoline, Lobeline
11%
D)Nicotine, ergotamine, Arecoline, Lobeline
❤2
The scientific name for areca is
Anonymous Quiz
12%
A)areca nut
21%
B)palmaceae
65%
C)areca catechu
2%
D)laliaceae
The important alkaloids of areca
Anonymous Quiz
31%
A)arecoline
2%
B)nicotine
2%
C)arecaidine
65%
D)both a&c
Root bark of Punica granatum contains piperidine alkaloids, one of which is solid
Anonymous Quiz
32%
A. pelletierine
48%
B. pseudopelletierine
8%
C. methylpelletierine
6%
D. isopelletierine
5%
E. methyliso pelletierine