Insulin, Growth hormone (GH), Prolactin and Parathvroid hormone (PTH break

Amides are hydrolyzed slowly in comparison to esters.

improve the poor oral absorption of carbenicillin, a lipophilic ....... has been formulated. Once orally absorbed, the ester is hydrolyzed rapidly to the parent drug.

Accordingly, antibiotics such as chloramphenicol and clindamycin have been derivatized as their palmitate esters to

Many parent drugs have been chemically modified or derivatized to generate so-called prodrugs to overcome some undesirable property

1..ester hydrolysis is the metabolic conversion of aspirin (acetylsalicylic acid) to salicylic acid.

2.. cocaine, it appears that, in general, the methyl group is hydrolyzed preferentially to yield benzoylecgonine

pseudocholinesterases present in

Several nonspecific esterases found in

Amide hydrolysis appears to be mediated by ...microsomal ( Amidases, Esterases and Deacylases).