Protein binding can have a profound effect on the drug's effective solubility, bio distribution, half-life in the body, and interaction with other drugs.

suramin remains in the body in the protein-bound form for as long as ... months (t1/2 =50 days).

Lidocaine first-pass effect

lidocaine's half-life of less than .. hours, tocainide's half-life is approximately 15 hours, with

About 75% to 80% of phenacetin (now withdrawn from the U.S. market) is converted to .....

nonsteroidal anti-inflammatory drugs combine with the desired cyclooxygenase receptors at the site of the inflammation and the undesired cyclooxygenase receptors in the gastrointestinal mucosa

Insulin, Growth hormone (GH), Prolactin and Parathvroid hormone (PTH break