brain is not exposed to the same variety of compounds that other organs

prodrug

The acetate ester is found in topical ointments and sterile aqueous suspensions for ...

Etretinate has a ..... terminal half-life

acitretin, has a 33to 96-hour terminal half-life.

Protein binding can have a profound effect on the drug's effective solubility, bio distribution, half-life in the body, and interaction with other drugs.

suramin remains in the body in the protein-bound form for as long as ... months (t1/2 =50 days).

Lidocaine first-pass effect

lidocaine's half-life of less than .. hours, tocainide's half-life is approximately 15 hours, with

About 75% to 80% of phenacetin (now withdrawn from the U.S. market) is converted to .....

nonsteroidal anti-inflammatory drugs combine with the desired cyclooxygenase receptors at the site of the inflammation and the undesired cyclooxygenase receptors in the gastrointestinal mucosa