An understanding of the metabolic labile site on lidocaine led to the development of:
A- the quaternary ammonium analog tocanidc. B- The secondary amine prodrug tocainide.
C- The tertiary amine prodrug tocainidc. D-The primary amine analog tocainidc.

A study of the metabolic fate of a drug is required for all new drug products. Often it is found that the metabolites are also active.

Examples of an inactive parent drug that is converted to an active metabolite include the nonsteroidal anti-inflammatory agent sulindac being reduced to the active

In the tcracyclic antidepressant series, imipraminc and nortriptyline amitriptyline arc N-demethylated
to desipraminc and, respectively All four compounds have been marketed in the United Slates.

In the tricyclic antidepressant secies imipramine and amitriptyline are N-demethylated to
A- Nortriptyline and Dcsipramlne. B-desipramine and Nortriptyline
C-Mapritylmc and Dcsipramine. D-Desipramine and Mapritylmc.

Nursing mothers must be concerned, because drugs and their metabolites can be excreted in human milk and be ingested by the nursing infant.

Receptors include a relatively small region of a macromolecule, which may be an:

The more advanced method of receptor isolation

The ability of the drug to dissolve is governed by several laclot Including

Chloramphenicol producing an unpalatable bitterness. To mask this intense bitter taste, the

brain is not exposed to the same variety of compounds that other organs

prodrug

The acetate ester is found in topical ointments and sterile aqueous suspensions for ...

Etretinate has a ..... terminal half-life

acitretin, has a 33to 96-hour terminal half-life.

Protein binding can have a profound effect on the drug's effective solubility, bio distribution, half-life in the body, and interaction with other drugs.

suramin remains in the body in the protein-bound form for as long as ... months (t1/2 =50 days).

Lidocaine first-pass effect