A drug has a high volume of distribution (Vd). Which statement is most likely correct?
Anonymous Quiz
9%
The drug is mainly confined to plasma
74%
The drug is extensively distributed into tissues
14%
The drug is rapidly eliminated by kidneys
3%
The drug has poor tissue penetration
๐1
Which of the following drugs is a competitive antagonist?
Anonymous Quiz
49%
Phenoxybenzamine
39%
Atropine
7%
Aspirin
5%
Diazepam
๐1
A competitive antagonist generally causes:
Anonymous Quiz
8%
Decrease in Emax with no change in EC50
68%
Rightward shift of dose-response curve with no change in Emax
16%
Leftward shift of dose-response curve with increased Emax
9%
Decrease in both Emax and EC50
๐1
Which of the following is a characteristic of a partial agonist?
Anonymous Quiz
13%
Produces the same maximal response as a full agonist
7%
Has no affinity for the receptor
80%
Produces a submaximal response even when all receptors are occupied
1%
Irreversibly binds to the receptor
๐1
Which pharmacokinetic process follows zero-order kinetics?
Anonymous Quiz
10%
Renal excretion of most drugs
49%
Hepatic metabolism at low drug concentration
28%
Elimination of ethanol
14%
Renal tubular secretion at low concentration
โค1
A drug has a half-life of 4 hours and follows first-order kinetics. Approximately what percentage of the drug remains after 12 hours?
Anonymous Quiz
9%
50%
23%
25%
46%
12.5%
22%
6.5%
๐2๐1
Which of the following increases the duration of action of a drug?
Anonymous Quiz
3%
Increased renal clearance
25%
Increased hepatic metabolism
43%
Decreased drug clearance
29%
Decreased plasma protein binding
โค1
โค1
Under the Drugs & Cosmetics Act, 1940, which authority is primarily responsible for approval of new drugs for manufacture/import?
Anonymous Quiz
11%
State Licensing Authority
57%
Central Licensing Authority
23%
Drug Consultative Committee
9%
Pharmacy Council of India
๐1
A drug is considered spurious when:
Anonymous Quiz
7%
Its label is misleading
13%
It contains less active ingredient than required
70%
It is manufactured under a name belonging to another drug
10%
It has deteriorated due to improper storage
๐ฅฐ1
Which Schedule of the Drugs & Cosmetics Rules is primarily associated with Good Manufacturing Practices (GMP)?
Anonymous Quiz
4%
Schedule H
94%
Schedule M
1%
Schedule J
1%
Schedule Y
๐1
Which of the following is a key duty of a Drug Inspector?
Anonymous Quiz
1%
Granting a pharmacy degree
96%
Inspecting licensed premises and taking samples of drugs
3%
Fixing prices of all medicines
1%
Approving medical colleges
๐1
Which body advises the Central and State Governments on technical matters arising from administration of the Drugs & Cosmetics Act?
Anonymous Quiz
9%
PCI
15%
DCC
52%
DTAB
24%
CDSCO
๐1
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๐1
Furosemide acts by inhibiting the following in the renal tubular cell:
Anonymous Quiz
81%
Na+-K+-2Clโ cotransporter
8%
Na+-Clโ symporter
2%
Na+-H+ antiporter
9%
Na+ K+ ATPase
The following diuretic abolishes the corticomedullary osmotic gradient in the kidney.
Anonymous Quiz
29%
Acetazolamide
19%
Furosemide
30%
Hydrochlorothiazide
22%
Spironolactone
โค1
Parenteral furosemide is an alternative diuretic to mannitol in the following condition.
Anonymous Quiz
41%
Pulmonary edema
18%
Cirrhotic edema
33%
Cerebral edema
8%
Cardiac edema
The following tissue is most sensitive to vasopressin:
Anonymous Quiz
9%
Intestinal smooth muscle
47%
Vascular smooth muscle
15%
Uterus
29%
Renal collecting ducts