Which of the following is a noncatecholamine sympathomimetic
Anonymous Quiz
14%
Adrenaline
41%
Ephedrine
20%
Dopamine
25%
Isoprenaline
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Which of the following routes of administration completely avoids first-pass hepatic metabolism?
Anonymous Quiz
9%
Oral
19%
Rectal
63%
Sublingual
10%
Intraduodenal
👍1
Which pharmacokinetic parameter is most directly related to the rate of drug elimination?
Anonymous Quiz
25%
Volume of distribution
12%
Bioavailability
55%
Clearance
8%
Half-life
👍1
A drug has a high volume of distribution (Vd). Which statement is most likely correct?
Anonymous Quiz
9%
The drug is mainly confined to plasma
74%
The drug is extensively distributed into tissues
14%
The drug is rapidly eliminated by kidneys
3%
The drug has poor tissue penetration
👍1
Which of the following drugs is a competitive antagonist?
Anonymous Quiz
49%
Phenoxybenzamine
39%
Atropine
7%
Aspirin
5%
Diazepam
👍1
A competitive antagonist generally causes:
Anonymous Quiz
8%
Decrease in Emax with no change in EC50
68%
Rightward shift of dose-response curve with no change in Emax
16%
Leftward shift of dose-response curve with increased Emax
9%
Decrease in both Emax and EC50
👍1
Which of the following is a characteristic of a partial agonist?
Anonymous Quiz
13%
Produces the same maximal response as a full agonist
7%
Has no affinity for the receptor
80%
Produces a submaximal response even when all receptors are occupied
1%
Irreversibly binds to the receptor
👍1
Which pharmacokinetic process follows zero-order kinetics?
Anonymous Quiz
10%
Renal excretion of most drugs
49%
Hepatic metabolism at low drug concentration
28%
Elimination of ethanol
14%
Renal tubular secretion at low concentration
❤1
A drug has a half-life of 4 hours and follows first-order kinetics. Approximately what percentage of the drug remains after 12 hours?
Anonymous Quiz
9%
50%
23%
25%
46%
12.5%
22%
6.5%
👏2👍1
Which of the following increases the duration of action of a drug?
Anonymous Quiz
3%
Increased renal clearance
25%
Increased hepatic metabolism
43%
Decreased drug clearance
29%
Decreased plasma protein binding
❤1
❤1