2. What is the main difference between type 1 and type 2 diabetes?

Insulin is a polypeptide hormone consisting of three peptide chains

proinsulin that undergoes proteolytic cleavage to form insulin and C-peptide both of which are secreted by

duration action of Sulfonylureas is

Adverse effects of sulfonylureas is

Glinides should be taken after to a meal

Glinides similar to sulphonyl urea but doesn’t have sulphonyl group

glinides cause hypoglycemia and weight gain, the incidence is higher than that with sulfonylureas

metformin similar sulfonylureas that does not promote insulin secretion

is useful in treatment of polycystic ovary syndrome

Hypoglycemia doesn’t occur when metformin is taken with insulin

is not bound to serum proteins, and is not metabolized. Excretion is via the urine

pioglitazone and rosiglitazone are with groups called

Metformin should be used with caution in patients less than 80 years and in those HF or alcohol abuse

Block k channel and open Ca channel is

Pioglitazone act to inhibit PPARY

Pioglitazone and rosiglitazone are undergo extensive metabolism by different CYP450 isozymes

Emapagliflozin act to treatment Type2 diabetes and indicated to reduce the risk of cardiovascular disease

All DPP-4 inhibitors except linagliptin require dosage adjustments in renal dysfunction

Canagliflozin should be taken after the first meal

Acarbose inhibit of Alfa glucosidase enzyme