Acetylation: the most common conjugative pathway in drug metabolism

Acetylation greatly increases the water solubility

occurs primarily with phenols and,
occasionally, with alcohols, aromatic amines, and N-hydroxy compounds

Sulfate Conjugation: occurs primarily with phenols and,
occasionally, with alcohols, aromatic amines, and N-hydroxy compounds

compound combines with sulfates It is considered the main urinary product.

N,O,S

Hydroxylation or oxidation of the heteroatom (S )