Q1. A 60-year-old man died secondary to coronary artery disease. At the
time of autopsy marked atherosclerotic changes were present within his coro-
nary arteries. Sections from these abnormal areas revealed complicated ather-
osclerotic plaques with calcification and hemorrhage. Within these plaques
were cellular zones, composed of smooth-muscle cells and macrophages, and
a central core with foam cells and cholesterol clefts. These foam cells are
smooth-muscle cells or macrophages that have phagocytized lipid. Which
one of the following substances promotes atherosclerosis by stimulating
smooth-muscle cells to proliferate, phagocytize lipid, and excrete extracellular
matrix material?
a. Alpha-interferon
b. Beta-transforming growth factor
c. Interleukin 1
d. Platelet-derived growth factor
e. Tumor necrosis factor
time of autopsy marked atherosclerotic changes were present within his coro-
nary arteries. Sections from these abnormal areas revealed complicated ather-
osclerotic plaques with calcification and hemorrhage. Within these plaques
were cellular zones, composed of smooth-muscle cells and macrophages, and
a central core with foam cells and cholesterol clefts. These foam cells are
smooth-muscle cells or macrophages that have phagocytized lipid. Which
one of the following substances promotes atherosclerosis by stimulating
smooth-muscle cells to proliferate, phagocytize lipid, and excrete extracellular
matrix material?
a. Alpha-interferon
b. Beta-transforming growth factor
c. Interleukin 1
d. Platelet-derived growth factor
e. Tumor necrosis factor
ูุฐุง ุณุคุงู ุนู pathogenesis ุณุคุงู ู
ุจุงุดุฑ .. ุงูุฑูุง ุงูุณุคุงู ูููุณ
Q2 . The most common site of atherosclerosis is :
a. Coronary arteries
b. Descending thoracic aorta
c. Lower abdominal aorta
d. Internal carotid arteries
e. Circle of Willis
a. Coronary arteries
b. Descending thoracic aorta
c. Lower abdominal aorta
d. Internal carotid arteries
e. Circle of Willis
Q3 .Which of the following is the first event in atherosclerosis pathogenesis :
a. Accumulation of lipoproteins
b. Lipid accumulation
c. Smooth muscle cells recruitment
d. Endothelial cell injury
e. Monocyte adhesion
a. Accumulation of lipoproteins
b. Lipid accumulation
c. Smooth muscle cells recruitment
d. Endothelial cell injury
e. Monocyte adhesion
Q4 . During a routine physical examination, a 60-year-old man is found to have a 5-cm
pulsatile mass in his abdomen. Angiography reveals a marked dilation of his aorta distal
to his renal arteries. Which of the following is the most likely cause of this aneurysm?
a. Atherosclerosis
b. A congenital defect
c. Hypertension
d. A previous syphilitic infection
e. Trauma
pulsatile mass in his abdomen. Angiography reveals a marked dilation of his aorta distal
to his renal arteries. Which of the following is the most likely cause of this aneurysm?
a. Atherosclerosis
b. A congenital defect
c. Hypertension
d. A previous syphilitic infection
e. Trauma
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