#Gross

#Diagnosis 👉🏻 rear fatty streaks in the aorta in the adult ( normal )

#The_white_arrow
Ostia of branch vessels

#The_black_arrows
Reddish staining dut to the hemoglobin that leaked from RBC’s following death

#Gross

#Diagnosis 👉🏻 fatty streaks in the aorta

#The_white_arrows
Fatty streak that show pale yellow

#Microscopic

#Diagnosis 👉🏻 fatty streaks
وكيف نقدر نعرف من خلال وجود تجمعات من Foam cell فقط

#The_black_arrow
Macrophage

#Gross

#Diagnosis 👉🏻 atherosclerosis

#The_black_arrow
Mild fibrous plaque

#The_white_arrow
Sever plaque with thrombosis

#The_red_arrow
Sever plaque without thrombosis

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis

#The_black_arrow
Foam cell

#The_red_arrow
Cholesterol clefts

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis

#L
Moderate narrowed

#F
Fibrous cap

* composed of
- smooth cell
- macrophages
- collagen
- foam cell
- new blood vessels

#C
Central necrotic core

* composed of
- cholesterol cleft
- calcification
- cell debris
- foam cell

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis

#The_arrowhead
Calcification
وكيف عرفنا انه تكلس بسبب انه ظهر لونه bluish في صبغة H&E

#The_small_arrows
Neovascularization

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis in coronary artery with thrombosis

#The_black_arrow
Thrombosis
وكيف عرفنا انه هنا جلطة بسبب لونها الوردي المائل الى الأحمر وكمان لانها قسمت لي الـ lumen الى قسمين والتي تظهر متضيقة

#The_red_arrows
Narrow channels

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis with thrombosis

#The_black_arrow
Cholesterol clefts

#The_asterisk
Thrombosis

وزي ما قلنا اول عرفنا انه معانا جلطة بسبب لونها الوردي المائل للأحمر لكن هنا مابش معانا lumen لانها الجلطة سدتها

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis


#The_black_arrows
Inflammatory cell ( lymphocytes )

#The_red_arrows
Foam cell

#The_green_arrow
Cholesterol cleft

#Microscopic

#Diagnosis 👉🏻 Early fatty streaks

طيب كيف عرفنا ؟! بسبب انه الـ microphages لسه بدأت تبتلع LDL بحيث بتشوف microphages لسه ماقد ابتلعت LDL

#The_black_arrow
Foam cell and som microphages not filled the LDL

#Gross

#Diagnosis 👉🏻 Atherosclerosis with hemorrhage


#The_black_arrow
Hemorrhage

#The_white_arrow
Atheroma

#Microscopic

#Diagnosis 👉🏻 Atherosclerosis with hemorrhage


#The_black_arrow
Hemorrhage

#The_green_arrow
Atheroma

#Gross

#Diagnosis 👉🏻 thrombus in coronary artery


#The_white_arrow
Thrombosis

#Microscopic

#Diagnosis 👉🏻 fibro-lipid plaque


#The_black_arrow
Fibro-lipid

#The_red_arrow
Calcification

🌸 Atherosclerosis

..•● Acute myocardial infraction ●•..

#Definition
⁃ is necrosis of the heart muscle that occurs when blood flow to the heart muscle is abruptly cut off( ischemia) causing tissue damage , also known as a heart attack .


#Causes
• Atherosclerosis
• And anything caused ischemia


#Common_in
• males ( from 45-54 years )


#Clinical_features
• Cheats pain
• Increase heart rate
• shortness of breath
• And other

#Gross_description
• necrosis appears yellow tan
• Hyperemia that surround necrosis
• Hemorrhage
• Scar


#Microscopic_description
• wavy fibers & necrotic cell
separated by edema fluid ( in 1
day )
• Neutrophilic ( in a 2-3 day )
• Macrophages removal of necrotic
( in a 7-10 days )
• Granulation tissue ( after 11 days)
• Healed


#اللجنة_العلمية_للدفعة_الخامسة
#قسم_الباثولوجي
#عمل_نوال_المخلافي