Cervical intra-epithelial neoplasia grade 3:

Microscopic features:

Red arrows:
marked full thickness atypia and loss of maturation; carries highest risk of progression to invasive squamous cell carcinoma

Yellow area:
Normal cervical tissue

🌸 The Grades of cervical squamous cell carcinoma

Poorly differentiated invasive cervical squamous cell carcinoma at low grade microscopic.

Microscopic features:

_ peliomorphism ( hyperchromatic nucleus)

Red arrow:
inflammatory cells infiltrated


Green arrow:
nest of atypia tumor cells

Blue arrow:
Loss of stromal tissue between the cells.

Black arrow:
Irregular basement membrane

#Microscopic

#Diagnosis 👉🏻 cervical squamous cell carcinoma

A ➪ Poorly differentiated
No keratinous pearls
Hyperchrmatic nucleus
Cell polymorphism
More N/C ratio

B ➪ Moderatly differentiated
C ➪ Well differentiated

Cervical adenocarcinoma in situ

Microscopic features:

Red arrows:
Irregular lumens of glandular tissue.

Blue arrows:
Hyperchromatic tumor cells, with peliomorphism.

Green arrow:
Normal cells

Acute endometritis

Microscopic features:

Black arrow:
endometrium with prominent intraluminal segemented neutrophils infiltrating glandular epithelium.

Blue arrow:
Congested blood

Chronic endometritis

Microscopic features:
Presence of infiltrated lymphocytes and plasma cells in the endometrium


Red arrows:
Lymphoid Follicles

Blue arrow:
Plasma cell

#MICROSCOPIC

#Diagnosis 👉🏻 Chronic endometritid

#The_black_arrow
Inflammatory cell infiltration (lymphocytes)

Gross endometrial polyps

Blue arrow:
High in the fundus and projecting into the endometrial cavity is a small benign endometrial polyp, and may cause uterine bleeding.

Endometrial polyp


Microscopic Features:

1)Polypoid mass
2)Yellow area ➱ Fibrovascular core
3)Green arrows ➱ Cystically dilated gland
4)Slightly Irregular proliferative glands

Endometrial polyp

Microscopic features:

Black arrow:
elongated shape, vascular pedicle ( fibro-vascular core)

Red arrows:
Accumulation of glandular tissue within the polyp

Endometrial Adenocarcinoma

Microscopic Features:
1)Glandular proliferation
2)Glands with irregular lumen
3)Hyperchromatic & pleomorphic cells
4)Cellular Atypia
5) ⇑ Mitotic figures
6) Intervening endometrial stroma

#GROSS

#Diagnosis 👉🏻 Leiomyoma

#The_red_arrow
submucosal

#The_black_arrow
intramural

#The_blue_arrow
subseroal

#MICROSCOPIC

#Diagnosis 👉🏻 Adenomyosis


Myometrium ( spindle shape )
Stroma ( dark )

#MICROSCOPIC

#Diagnosis 👉🏻 Adenomyosis

#The_black_arrows
Endometrial Gland

#The_red_arrows
Myometrium ( spindle shape )

#The_blue_arrow
Endometrial Stroma

Endometriosis in colon

حسب النظريات (theory ) لكن ماقد اثبتت علميا
ان سبب الانتقال للقولون هو انه حصل metaplasia ، او مهاجره عبر ال vessels


العلامات موضحة في السلايد.