Chronic cervicitis ..


cervicitis is 2 types as any inflammation :
1- Acute : filtration of neutrophil , congestive blood vessels
Causes :
Neissiria gonorrhea or post-partum(trauma)

2- chronic:
- infiltrated lymphocytes 🤎brown arrow 🤎
- congested blood vessels ❤️red arrow ❤️
- in the cervical glands cells become squamous metaplasia then Dysplasia then cancer (if it doesn't treat)

*If acute cervicitis not treat it become chronic

Chronic cervicitis ✨
*Chronic inflammation of the uterine cervix.
*Common in all women of reproductive age.

✅Microscopic Features:
1)Red arrow➱ congested blood vessels
2)Blue arrow➱Lymphocytes
3)Yellow arrow➱ Normal cervical gland

Cervical polyp = Endocervical polyp

- inflammatory cells filtered in stroma 💜 purple arrow 💜
- irregular dilated lumen and filled with mucus💙blue arrow💙
- proliferative and hyperplasia of glands🤍white arrow 🤍

Endocervical polyp✨ (low power)

✅Microscopic Features:
1)Red arrows ➱variably shaped endocervical glands.
2)Blue arrows➱ scattered mononuclear cells infiltrate.

Endocervical polyp✨(high power)

✅Microscopic Feature:
3)The stroma is edematous (لاحظ وجود الفقاعات الشفافة داخل )

Cervical squamous metaplasia✨
*Causes : Superimposed chronic inflammation of endocervical polyp may lead to Cervical squamous metaplasia .

✅Microscopic Feature :
1)Yellow area ➱Squamous metaplasia

Cervical Intraepithelial Lesion I [CIN I ]✨

✅Microscopic Features:
1)Green area ➱Dysplasia of the lower 1/3 of tissue
2)Red arrows ➱Koilocytotic changes

Cervical intra-epithelial neoplasia grade 2


Microscopic features:

Green arrows:
superficial cytoplasmic maturation; high rate of regression.

Red arrows:
diffuse nuclear enlargement, hyperchomasia.

Blue arrows:
Note the increased mitotic activity in the lower and middle thirds

Yellow arrows:
Koilocytosis

Cervical intra-epithelial neoplasia grade 3:

Microscopic features:

Red arrows:
marked full thickness atypia and loss of maturation; carries highest risk of progression to invasive squamous cell carcinoma

Yellow area:
Normal cervical tissue

🌸 The Grades of cervical squamous cell carcinoma

Poorly differentiated invasive cervical squamous cell carcinoma at low grade microscopic.

Microscopic features:

_ peliomorphism ( hyperchromatic nucleus)

Red arrow:
inflammatory cells infiltrated


Green arrow:
nest of atypia tumor cells

Blue arrow:
Loss of stromal tissue between the cells.

Black arrow:
Irregular basement membrane

#Microscopic

#Diagnosis 👉🏻 cervical squamous cell carcinoma

A ➪ Poorly differentiated
No keratinous pearls
Hyperchrmatic nucleus
Cell polymorphism
More N/C ratio

B ➪ Moderatly differentiated
C ➪ Well differentiated

Cervical adenocarcinoma in situ

Microscopic features:

Red arrows:
Irregular lumens of glandular tissue.

Blue arrows:
Hyperchromatic tumor cells, with peliomorphism.

Green arrow:
Normal cells

Acute endometritis

Microscopic features:

Black arrow:
endometrium with prominent intraluminal segemented neutrophils infiltrating glandular epithelium.

Blue arrow:
Congested blood

Chronic endometritis

Microscopic features:
Presence of infiltrated lymphocytes and plasma cells in the endometrium


Red arrows:
Lymphoid Follicles

Blue arrow:
Plasma cell

#MICROSCOPIC

#Diagnosis 👉🏻 Chronic endometritid

#The_black_arrow
Inflammatory cell infiltration (lymphocytes)

Gross endometrial polyps

Blue arrow:
High in the fundus and projecting into the endometrial cavity is a small benign endometrial polyp, and may cause uterine bleeding.

Endometrial polyp


Microscopic Features:

1)Polypoid mass
2)Yellow area ➱ Fibrovascular core
3)Green arrows ➱ Cystically dilated gland
4)Slightly Irregular proliferative glands

Endometrial polyp

Microscopic features:

Black arrow:
elongated shape, vascular pedicle ( fibro-vascular core)

Red arrows:
Accumulation of glandular tissue within the polyp

Endometrial Adenocarcinoma

Microscopic Features:
1)Glandular proliferation
2)Glands with irregular lumen
3)Hyperchromatic & pleomorphic cells
4)Cellular Atypia
5) ⇑ Mitotic figures
6) Intervening endometrial stroma