#MICROSCOPIC

#Diagnosis → poor differentiated SCC (grade 3)

#Features
Distributed cells
Nuclear atypia
Nuclear pleomorphism
NO KERATIN PEARLS
NO SQUAMOUS NESTS

NORMAL TESTS

NORMAL TESTS

#GROSS

#Diagnosis → testicular TB


Caseous necrosis has cheese-like appearance

#MICROSCOPIC

#Diagnosis → testicular TB

#The_black_area
Hematogenous area with less nucleus

#GROSS

#Diagnosis → cryptorchidism

#Left_testes
Atropic
Pale white in color

#MICROSCOPIC

#Diagnosis → cryptorchidism

#The_black_rhomboid
Atrophic tubule with no spermatogenesis

#The_blue_arrows
Pale stroma

#MICROSCOPIC

#Diagnosis → intratubular germ cell neoplasia

#Features
الخلايا السرطانية لازالت في الـ tubule
(no invasion)
Clear cytoplasm
Round prominent nucleoli

#MICROSCOPIC

#Diagnosis → intratubular germ cell neoplasia

#The_black_arrows
Prominent nucleoli with clear cytoplasm

#The_blue_arrows
The border of the tubule

▪️classic Seminoma

- has good prognosis
- patients 30-40 years old
- tumor marker is PAP (prostatic alkaline phosphatase)


#gross features
- yellowish- white mass
- lobulated
- well circumscribed
- No hemorrhage, No necrosis

#microscopic features
- large round cells
- large nuclei ( hyperchromatic)
- prominent nucleoli
- clear cytoplasm
- cells arranged in sheets or lobules with septa in between
- lymphocyte within the septa

#GROSS

#Diagnosis → classic seminoma germ cell neoplasm

#The_black_areas
Rounded lobulated yellow-white masses

#Features
No necrosis
No haemorrhage
Well circumscribed

#MICROSCOPIC

#Diagnosis → classic seminoma germ cell neoplasm

#The_blue_arrows
Inflammatory cells (lymphocytes)

#The_black_arrow
Fibrous septae (pink in color)

#MICROSCOPIC

#Diagnosis → classic seminoma germ cell neoplasm

#The_blue_arrows
Inflammatory cells (lymphocytes)

#The_black_arrow
Fibrous septae (pink in color)

#The_brown_arrows
Prominent nucleoli with clear cytoplasm

#MICROSCOPIC

#Diagnosis → spermatocytic tumour

#The_blue_arrow
bizzar nucleus cell

#Features
Highly pleomorphism
Prominent nucleoli with clear cytoplasm
Hyperchromatic cells
NO INFLAMMATORY CELLS
NO FIBROUS SEPTAE

#GROSS

#Diagnosis → non seminoma yolk sac tumour

#The_blue_arrow
Haemorrhage

#The_black_arrow
Necrosis

#The_brown_arrows
Cystic areas

#Features
Irregular, ill-defined shape
Poorly circumscribed

#MICROSCOPIC

#Diagnosis → non seminoma yolk sac tumour

#The_blue_arrows
Hyalinized stroma (pink, AFP)

#The_black_arrows
Schiller Duval bodies (red)

#Features
Small hyperchrmatic pleomorphism cells
It has a papillary structure with Schiller Duval body inside

✓ Alfa fetoprotein is elevated

#MICROSCOPIC

#Diagnosis → non seminoma yolk sac tumour

#The_blue_arrows
Cancer cells

#The_black_arrow
Schiller Duval body

#MICROSCOPIC

#Diagnosis → non seminoma yolk sac tumour

#The_black_arrows
Schiller Duval bodies in tubular (finger-like) structure

#MICROSCOPIC

#Diagnosis → non seminoma yolk sac tumour

#The_black_arrows
Hyalinized stroma in globular structure

#The_brown_arrows
Cancer cells

#GROSS

#Diagnosis → non seminoma embryonal carcinoma

#The_blue_arrows
Necrosis

#The_black_arrows
Haemorrhage

#Features
It has a worse prognosis than yolk sac tumour

#MICROSCOPIC

#Diagnosis → non seminoma embryonal carcinoma

#The_black_arrows
RBCs

#Features
It has a papillary structure but without Schiller Duval body inside
Its cells larger than yolk sac's cells