#Microscopic 

#Diagnosis 👉🏻  Acute myelogenous leukemia


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Myeloblast

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Aure rode

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Nucleoli

#Microscopic 

#Diagnosis 👉🏻  Acute myelomonocytic leukemia ( M4 )


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Basophil

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Monoblast ( the nucleus like kidney shape ) 👉🏻 large

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Myeloblast 👉🏻 small

#Microscopic 

#Diagnosis 👉🏻  Acute monocytic leukemia ( M5 )


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Monoblast

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Reniform nucleus

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Vacuole

#The_features
- The cytoplasm is gray color
- monocytes with reniform nucleus
- may contain vacuole

#Microscopic 

#Diagnosis 👉🏻  Acute erythroleukemia


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Anucleate erythrocyte
والتي يكون لونها ازرق عشان النواة اتكسرت

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Trilobulated nucleus in erythroblast

#Microscopic 
Blood film

#Diagnosis 👉🏻  Chronic lymohoid leukemia ( cll )


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Lymphocytes with a clumped chromatin

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Smudge cell

#Microscopic 
Marrow film

#Diagnosis 👉🏻  Chronic lymohoid leukemia ( cll )


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Lymphocytes

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Plasma cell

Chronic Myeloid Leukemia
Is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate


#The_pathogenesis
حصل  chromosomal translocation من الكرموسوم 9 الى الكرموسوم 22 والذي يسمى ايضاً Philadelphia chromosome ( هو انتقال جينات من الكرموسوم 9 الى الكرموسوم 22 )
فكون oncogene الذي عمل activation لل tyrosine kinase فأثر على نخاع العظم فصارت الخلايا تنتج بشكل كبير جداً

وتمثل نسبة هذا النوع من السرطان 20% فقط


✓ The CML Occurs in 2 different phases
- Chronic phase or crisis
- blast phase or crisis


ونفرق بينهم من خلال الاتي
❁ Chronic phase (CP)
• Leukocytosis (usually 12 - 1,000 x 10⁹/L, median: ~ 80 x 10⁹/L)
• < 2% blasts in blood
• < 5% blasts in bone marrow


❁ Blast phase (BP)
• ≥ 20% blasts in marrow or blood or the presence of an extramedullary proliferation of blasts

اي ان الخلايا immature تكون اكثر من mature بعكس في المرحلة المزمنة تكون immature cell قليلة جداً

#Microscopic 

#Diagnosis 👉🏻  Chronic myeloid ( myelogenous ) leukemia
In the chronic phase

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Segmented neutrophils

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Band neutrophils

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Bisophillic

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Myelocytes

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Promyelocyte

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Myeloblast