#Microscopic 

#Diagnosis 👉🏻  Acute lymphocytic leukemia ( L3 )


#The_black_arrows
Lymphocytes

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Vacuoles

#The_features
- Uncommon
- high nuclear cytoplasmic ratio
- characteristic vacuoles

#Microscopic 

#Diagnosis 👉🏻  Acute promyelocytic leukemia ( M3 )


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Reddish purple granules

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Nucleoli

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Lymphocyte

#The_features
- prominent nucleoli
- may note small lymphocyte
- the cytoplasm contain of reddish-purple granules

#The_pathogenesis
حصل genetic translocation على الكروموسوم (15;17) مما أدى إلى حدوث fusion gene الذي بدروه سبب abnormality to retinoic acid receptors الموجود على سطح promyelocyte وعشان كذا توقفت الخليه عن التمايز وما تحولت إلى myelocyt

✓ ممكن نعالج هذه الحاله بإعطاء المريض حقنة Vitamin A او retinoic acid

#Microscopic 

#Diagnosis 👉🏻  Acute megakaryocytic leukemia


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megakaryoblasts 👇🏻
Small mononuclear cells with intensely blue cytoplasm with peripheral blebs

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cytoplasm with peripheral blebs

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dysmorphic megakaryocytes with disaggregated nuclear lobes connected by small strands

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strands

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disaggregated nuclear lobes

#Microscopic 

#Diagnosis 👉🏻  Chronic lymohoid leukemia


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Smudge cells

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Lymphocytes ( mature )

#The_features
- small, mature lymphocytes
- Smudge cells
- Round nucleus, clumped chromatin with only small nucleoli and less cytoplasm


ال clumped chromatin هو عباره عن مجموعه من الكورماتين تجمعت مع بعض

مرفق صورة اوضح توضح شكل clumped chromatin

#The_black_circles
clumped chromatin in the lymphocyte

#Microscopic 
Blood film

#Diagnosis 👉🏻  Heary cell leukemia


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Villiform projection

#The_features
- Higher nuclear cytoplasmic ratio
- Condensed nuclear chromatin
- Irregular surface and pale blue cytoplasmic villiform projections
- Nucleus is paracentral