preprints202003.0422.v1.pdf
506.5 KB
SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2 | Preprints (2020)
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s41598-018-27256-w.pdf
SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2
"In this study, we used a high threshold of the PLAAC score for protein identification: only proteins with a high probability of prionogenic properties were included in the analysis. We found that all members of β-CoVs members contain PrDs in the S proteins. However, SARS-CoV-2 is the only member of β-CoVs that has a PrD in the RBD of the S protein that binds to the ACE2 receptor employed for host cell entry. Furthermore, we discovered specific amino acids (Q474, N481, Q493, Q498 and N501) that enable the prionogenity of the SARS-CoV-2 RBD that are not found in the RBD of SARS-CoV, of which Q474, Q498 and N501 directly contact within ACE2."
"In this study, we used a high threshold of the PLAAC score for protein identification: only proteins with a high probability of prionogenic properties were included in the analysis. We found that all members of β-CoVs members contain PrDs in the S proteins. However, SARS-CoV-2 is the only member of β-CoVs that has a PrD in the RBD of the S protein that binds to the ACE2 receptor employed for host cell entry. Furthermore, we discovered specific amino acids (Q474, N481, Q493, Q498 and N501) that enable the prionogenity of the SARS-CoV-2 RBD that are not found in the RBD of SARS-CoV, of which Q474, Q498 and N501 directly contact within ACE2."
KR20210028062A Physiological Saline Containing Graphene
https://worldwide.espacenet.com/patent/search/family/075143365/publication/KR20210028062A?q=pn%3DKR20210028062A
https://worldwide.espacenet.com/patent/search/family/075143365/publication/KR20210028062A?q=pn%3DKR20210028062A
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https://www.sinopeg.com/core-shell-structured-polyethylene-glycol-functionalized-graphene-for-energy-storage-polymer-dielectrics-combined-mechanical-and-dielectric-performances_n28
“Poly(ethylene glycol) (PEG), also known as poly(ethylene oxide) (PEO), is an amphiphilic polyether that is soluble both in water and most organic solvents. PEG and its derivatives are among the few polymers approved for medical uses by the FDA.
Functionalized PEG, also named activated PEG, is a family of PEG derivatives decorated with functional groups. Funtionalized PEGs are used broadly for drug PEGylation, polymer engineering, nantechnology, biotechnology, and biomedical engineering.”
This is the description given by Sinopeg, Chinese company that delivers PEGs for most Covid injection manufacturers.
Functionalized PEG, also named activated PEG, is a family of PEG derivatives decorated with functional groups. Funtionalized PEGs are used broadly for drug PEGylation, polymer engineering, nantechnology, biotechnology, and biomedical engineering.”
This is the description given by Sinopeg, Chinese company that delivers PEGs for most Covid injection manufacturers.
Sinopeg
Linear PEGs,branched PEGs,multi-arm PEGs Manufacturer | SINOPEG
SINOPEG provides high quality poly(ethylene glycol) derivatives:more varieties of chain structure/rich selection of functional groups/high reactives site functionalization ratio.Contact now!
From their September 2020 blog post we extract more details:
“The coupling of PEG to protein is also called protein polyglycolization, which is essentially a drug delivery technology. The coupling of activated peg with protein molecules can improve the three-dimensional space state of proteins, resulting in changes in various biochemical properties of proteins. For example, chemical stability increased, half-life prolonged, immunogenicity and toxicity decreased or disappeared, protein solubility increased. SINOPEG is a dynamic science company dedicated to drug delivery systems (DDS). SINOPEG are specialized in the R&D of long acting biopharmaceuticals, developing and manufacturing of block copolymers, lipids for drug delivery, medical devices, bio-engineering, and other broad uses.
Up to now, the FDA has approved 20 polyglycolic drugs. In addition to monoclonal antibodies, polyglycolic drugs have become the most powerful drug development technology.
As a leading company in polyethylene glycol derivatives (PEGs)， SINOPEG is capable of supplying small to large quantities of rich selection of PEG derivative products with unique molecular designs (chemical structure, molecular weights (MW)) and exceptional product quality control to serve bio-technology and pharmaceutical companies and research organizations worldwide.”
“The coupling of PEG to protein is also called protein polyglycolization, which is essentially a drug delivery technology. The coupling of activated peg with protein molecules can improve the three-dimensional space state of proteins, resulting in changes in various biochemical properties of proteins. For example, chemical stability increased, half-life prolonged, immunogenicity and toxicity decreased or disappeared, protein solubility increased. SINOPEG is a dynamic science company dedicated to drug delivery systems (DDS). SINOPEG are specialized in the R&D of long acting biopharmaceuticals, developing and manufacturing of block copolymers, lipids for drug delivery, medical devices, bio-engineering, and other broad uses.
Up to now, the FDA has approved 20 polyglycolic drugs. In addition to monoclonal antibodies, polyglycolic drugs have become the most powerful drug development technology.
As a leading company in polyethylene glycol derivatives (PEGs)， SINOPEG is capable of supplying small to large quantities of rich selection of PEG derivative products with unique molecular designs (chemical structure, molecular weights (MW)) and exceptional product quality control to serve bio-technology and pharmaceutical companies and research organizations worldwide.”
Sinopeg
Linear PEGs,branched PEGs,multi-arm PEGs Manufacturer | SINOPEG
SINOPEG provides high quality poly(ethylene glycol) derivatives:more varieties of chain structure/rich selection of functional groups/high reactives site functionalization ratio.Contact now!
POLYETHYLENE GLYCOL-ENGRAFTED GRAPHENE OXIDE AS BIOCOMPATIBLE MATERIALS FOR PEPTIDE NUCLEIC ACID DELIVERY INTO CELLS
https://pubmed.ncbi.nlm.nih.gov/29376329/
https://pubmed.ncbi.nlm.nih.gov/29376329/
OSINT
POLYETHYLENE GLYCOL-ENGRAFTED GRAPHENE OXIDE AS BIOCOMPATIBLE MATERIALS FOR PEPTIDE NUCLEIC ACID DELIVERY INTO CELLS https://pubmed.ncbi.nlm.nih.gov/29376329/
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kim2016.pdf
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Facilitation of Polymerase Chain Reaction with Poly(ethylene glycol)-Engrafted Graphene Oxide Analogous to a Single-Stranded-DNA Binding Protein [source]
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kim2016.pdf
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Facilitation of Polymerase Chain Reaction with Poly(ethylene glycol)-Engrafted Graphene Oxide Analogous to a Single-Stranded-DNA…
Polymerase chain reaction (PCR), a versatile DNA amplification method, is a fundamental technology in modern life sciences and molecular diagnostics. After multiple rounds of PCR, however, nonspecific DNA fragments are often produced and the amplification…
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Method and process to make and use cotton-tipped electrochemical immunosensor for the detection of corona virus United States Patent 11035817
https://www.freepatentsonline.com/11035817.html
https://www.freepatentsonline.com/11035817.html