OSINT
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566888/
PubMed Central (PMC)
Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral…
Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interaction ...
Radicals and cytokines are intimately involved in the genesis of the endothelial damage, which is the common denominator of multi-organ failure in COVID-19. When ARDS occurs, ROS, RNS and cytokine production is out of control, and attempting to contrast all with a single cytokine inhibitor is doomed to fail. Only one drug is capable of inhibiting the production of all three of these classes of substance: methylene blue.
Methylene blue inhibits the formation of superoxide anion (ROS precursor) by blocking the xanthine oxidase pathway; it counteracts the synthesis of nitric oxide (RNS precursor) by direct inhibition of NO-synthase, and inhibits cytokine expression via attenuation of NF-kB signaling.
Methylene blue is a tricyclic phenothiazine, approved by the FDA and EMA for the treatment of methaemoglobinaemia and malaria. It is also used to inactivate viruses in blood products for transfusion, in the presence of UV light. Recent (non peer-reviewed) in vitro studies indicate that it has antiviral activity in the absence of UV light, strengthening the rationale for its use in COVID-19.
However, methylene blue use in patients with glucose-6-phosphate dehydrogenase deficiency is contraindicated due to increased risk of haemolytic anemia. Its concomitant use with serotonin reuptake inhibitors is also contraindicated. Methylene blue is a potent reversible inhibitor of monoamine oxidase A (the enzyme that catalyses serotonin breakdown) and concomitant use with serotonin reuptake inhibitors can inhibit the degradation of serotonin and increase its concentration to toxic levels (serotonin syndrome).
Methylene blue inhibits the formation of superoxide anion (ROS precursor) by blocking the xanthine oxidase pathway; it counteracts the synthesis of nitric oxide (RNS precursor) by direct inhibition of NO-synthase, and inhibits cytokine expression via attenuation of NF-kB signaling.
Methylene blue is a tricyclic phenothiazine, approved by the FDA and EMA for the treatment of methaemoglobinaemia and malaria. It is also used to inactivate viruses in blood products for transfusion, in the presence of UV light. Recent (non peer-reviewed) in vitro studies indicate that it has antiviral activity in the absence of UV light, strengthening the rationale for its use in COVID-19.
However, methylene blue use in patients with glucose-6-phosphate dehydrogenase deficiency is contraindicated due to increased risk of haemolytic anemia. Its concomitant use with serotonin reuptake inhibitors is also contraindicated. Methylene blue is a potent reversible inhibitor of monoamine oxidase A (the enzyme that catalyses serotonin breakdown) and concomitant use with serotonin reuptake inhibitors can inhibit the degradation of serotonin and increase its concentration to toxic levels (serotonin syndrome).
PubMed
Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion…
Tissue oxidases, especially xanthine oxidase, have been proposed as primary sources of toxic oxygen radicals in many experimental models of disease states. Among these, ischemia-reperfusion injury may be of the greatest clinical interest. In this paper we…
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Association of American Physicians and Surgeons: Winning the War Against Therapeutic Nihilism & Trusted Treatments vs Untested Novel Therapies
Peter McCullough, MD, MPH speaks at the 78th Annual Meeting of AAPS on October 2, 2021.
Slides: https://www.scribd.com/document/530328436/Slides-from-Peter-McCullough-MD-Oct-1-2021-Lecture
Patient Guide: https://aapsonline.org/covidpatientguide/
[source]
Peter McCullough, MD, MPH speaks at the 78th Annual Meeting of AAPS on October 2, 2021.
Slides: https://www.scribd.com/document/530328436/Slides-from-Peter-McCullough-MD-Oct-1-2021-Lecture
Patient Guide: https://aapsonline.org/covidpatientguide/
[source]
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A powerful speech from Robert F. Kennedy, Jr. at the Broadway Rally for Freedom on 16th October 2021
"Everyone in this crowd has a feeling of discomfort regarding what is happening to them. What happened to our country? How did all these countries in the world, in one lock-step move, pivot and end democracy. Impose authoritarian control all at once. All over the globe? How did that happen?"
"Everyone in this crowd has a feeling of discomfort regarding what is happening to them. What happened to our country? How did all these countries in the world, in one lock-step move, pivot and end democracy. Impose authoritarian control all at once. All over the globe? How did that happen?"
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Blood Tests Reveal Pfizer-BioNTech's COVID "Investigational Vaccine" Creates Blood Clots Under Microscope
Dr. Fleming shows the deleterious effects of the Pfizer gene therapy investigational vaccine. In late 2020, before the Pfizer investigational vaccine gene thearpy had even been rolled out, top scientists and experts around the world warned the Pfizer and Moderna products posed extreme risk of causing blood clots, myocarditis and other cardiovascular problems. One year later, Pfizer and Moderna have been forced to issue warnings confirming their controversial mRNA gene thearpy can, indeed, cause a long list of problems not just limited to the cardiovascular system.
note: see comment section for a more thorough electron microscopy analysis/counter-argument by Dr. Robert Young, as well as additional resources.
Dr. Fleming shows the deleterious effects of the Pfizer gene therapy investigational vaccine. In late 2020, before the Pfizer investigational vaccine gene thearpy had even been rolled out, top scientists and experts around the world warned the Pfizer and Moderna products posed extreme risk of causing blood clots, myocarditis and other cardiovascular problems. One year later, Pfizer and Moderna have been forced to issue warnings confirming their controversial mRNA gene thearpy can, indeed, cause a long list of problems not just limited to the cardiovascular system.
note: see comment section for a more thorough electron microscopy analysis/counter-argument by Dr. Robert Young, as well as additional resources.
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Bonhoeffer‘s Theory of Stupidity
Dietrich Bonhoeffer's argues that stupid people are more dangerous than evil ones. This is because while we can protest against or fight evil people, against stupid ones we are defenseless — reasons fall on deaf ears. Bonhoeffer's famous text serves any free society as a warning of what can happen when certain people gain too much power.
References
Dietrich Bonhoeffer
Bonhoeffer on Stupidity (entire quote)
Bonhoeffer Pastor, martyr, prophet, spy (Student edition)
[source]
Dietrich Bonhoeffer's argues that stupid people are more dangerous than evil ones. This is because while we can protest against or fight evil people, against stupid ones we are defenseless — reasons fall on deaf ears. Bonhoeffer's famous text serves any free society as a warning of what can happen when certain people gain too much power.
References
Dietrich Bonhoeffer
Bonhoeffer on Stupidity (entire quote)
Bonhoeffer Pastor, martyr, prophet, spy (Student edition)
[source]