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https://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2020;volume=22;issue=3;spage=98;epage=104;aulast=Mathai
www.marinemedicalsociety.in
Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience Mathai SS, Behera…
Journal of Marine Medical Society, India
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https://www.biorxiv.org/content/10.1101/2021.05.05.442779v1
bioRxiv
ProLung
™
-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation
Background Inhaled budesonide benefits patients with COVID-19. ProLung
™
-budesonide enables the sustained, low dose administration of budesonide within a delivery vehicle similar to lung surfactant. ProLung
™
-budesonide may offer anti-inflammatory and protective…
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https://www.bmj.com/content/369/bmj.m1548/rr-6
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821804/
PubMed Central (PMC)
The vitamin D–antimicrobial peptide pathway and its role in protection against infection
Vitamin D deficiency has been correlated with increased rates of infection. Since the early 19th century, both environmental (i.e., sunlight) and dietary sources (cod liver) of vitamin D have been identified as treatments for TB. The recent discovery ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659525/
PubMed Central (PMC)
Administration of oral vitamin D induces cathelicidin production in atopic individuals
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001888/
PubMed Central (PMC)
Vitamin D Induction of the Human Antimicrobial Peptide Cathelicidin in the Urinary Bladder
The urinary tract is frequently being exposed to potential pathogens and rapid defence mechanisms are therefore needed. Cathelicidin, a human antimicrobial peptide is expressed and secreted by bladder epithelial cells and protects the urinary tract from ...
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https://www.ncbi.nlm.nih.gov/pubmed/20302931
PubMed
Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future - PubMed
Vitamin D was discovered as the preventive agent of nutritional rickets, a defect in bone development due to inadequate uptake of dietary calcium. However, a variety of studies over the last several years has revealed that vitamin D controls much more than…
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542722/
PubMed Central (PMC)
The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins
LL-37, the only human cathelicidin, is a cationic antimicrobial peptide with antibacterial and antifungal activity. LL-37 is released from neutrophil granules and produced by epithelial cells. It has been implicated in host defence against influenza A ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308600/
PubMed Central (PMC)
Vitamin D and the anti-viral state
Vitamin D has long been recognized as essential to the skeletal system. Newer evidence suggests that it also plays a major role regulating the immune system, perhaps including immune responses to viral infection. Interventional and observational epidemiological…
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256336/
PubMed Central (PMC)
Antimicrobial implications of vitamin D
Evidence exists that vitamin D has a potential antimicrobial activity and its deficiency has deleterious effects on general well-being and longevity. Vitamin D may reduce the risk of infection through multiple mechanisms. Vitamin D boosts innate immunity…
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488782/
PubMed Central (PMC)
Modulation of the Immune Response to Respiratory Viruses by Vitamin D
Background: Vitamin D deficiency has been shown to be independently associated with increased risk of viral acute respiratory infection (ARI) in a number of observational studies, and meta-analysis of clinical trials of vitamin D supplementation for prevention…
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https://news.northwestern.edu/stories/2020/05/vitamin-d-appears-to-play-role-in-covid-19-mortality-rates/
news.northwestern.edu
Vitamin D appears to play role in COVID-19 mortality rates
Patients with severe deficiency are twice as likely to experience severe complications, including death
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https://www.sciencedaily.com/releases/2020/05/200512134426.htm
ScienceDaily
Vitamin D determines severity in COVID-19 so government advice needs to change, experts urge
Researchers are urging the Irish government to immediately change recommendations on vitamin D supplements given recent changes by Welsh, English and Scottish governments.
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https://www.sciencedirect.com/science/article/abs/pii/S000629520900728X
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https://www.liebertpub.com/doi/full/10.1089/ars.2013.5447
Antioxidants & Redox Signaling
Are Reactive Oxygen Species Always Detrimental to Pathogens? | Antioxidants & Redox Signaling
Abstract Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by causing oxidative damage to biocompounds or indirectly by stimulating pathogen…
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https://www.sciencedirect.com/science/article/abs/pii/0166354295009779
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https://www.ingentaconnect.com/content/ben/cmc/2006/00000013/00000015/art00004
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https://www.sciencedirect.com/science/article/abs/pii/S0166354218305710
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https://www.pnas.org/content/87/12/4884.short
PNAS
Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.
We show that the stimulation of human immunodeficiency virus (HIV) brought about by tumor necrosis factor alpha and phorbol 12-myristate 13-acetate can be inhibited by adding N-acetyl-L-cysteine (NAC). NAC, which replenishes intracellular glutathione, effectively…