OSINT
https://patents.google.com/patent/US10786570B2/en #ferritin
PubMed
Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles - PubMed
Means for temporally regulating gene expression and cellular activity are invaluable for elucidating underlying physiological processes and would have therapeutic implications. Here we report the development of a genetically encoded system for remote regulation…
A “self-assembling” system means that a person is injected with instructions that set into motion a process where a structure is assembled inside the body, using resources available in the blood (such as iron and oxygen atoms). In effect, nanotech self-assembly means that a microchip doesn’t need to be “injected” into someone, since the circuitry can be assembled in vivo after injection.
Every biological creature on Earth is a living example of self-assembly, by the way, since DNA is a self-assembled nanostructure. Genetic replication is, of course, a process rooted in self-assembly. So anyone who doesn’t realize self-assembly is a real phenomenon is rather ignorant, even about the mechanisms at work in their own body. Viral replication is also a self-assembly process, of course.
“A myriad of magnetic nanosystems can be created by using self-assembly as a synthetic tool,” says the abstract of a study published in January of this year. Published in the journal Aggregate Open Access, it’s entitled: Self-assembled magnetic nanomaterials: Versatile theranostics nanoplatforms for cancer (https://onlinelibrary.wiley.com/doi/10.1002/agt2.18)
The paper focuses on, “Self-assembled magnetic nanomaterials (MNMs)” and details their use in biomedicine, writing:
[M]agnetic fields have been widely used for nanomaterials assembled of one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) aggregates.
Every biological creature on Earth is a living example of self-assembly, by the way, since DNA is a self-assembled nanostructure. Genetic replication is, of course, a process rooted in self-assembly. So anyone who doesn’t realize self-assembly is a real phenomenon is rather ignorant, even about the mechanisms at work in their own body. Viral replication is also a self-assembly process, of course.
“A myriad of magnetic nanosystems can be created by using self-assembly as a synthetic tool,” says the abstract of a study published in January of this year. Published in the journal Aggregate Open Access, it’s entitled: Self-assembled magnetic nanomaterials: Versatile theranostics nanoplatforms for cancer (https://onlinelibrary.wiley.com/doi/10.1002/agt2.18)
The paper focuses on, “Self-assembled magnetic nanomaterials (MNMs)” and details their use in biomedicine, writing:
[M]agnetic fields have been widely used for nanomaterials assembled of one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) aggregates.
Wiley Online Library
Self‐assembled magnetic nanomaterials: Versatile theranostics nanoplatforms for cancer
Self-assembled magnetic nanomaterials are a class of promising biomaterials possessing excellent physiochemical and biological characteristics. This Review aims to provide a systematical overview of ...
The study makes reference to the self-assembly of iron oxide nanoparticles, which can exhibit magnetic properties in certain configurations. These are known as SPIONs (Super Paramagnetic Iron Oxide Nanoparticles).
The paper explains:
This approach could be used for the assembling process of other MNPs such as Ni NPs, Co NPs, and Fe3O4 NPs. Such self-assembly strategy might play an important role in the construction of DDSs. (Drug Delivery Systems)
Additionally, the paper makes reference to self-assembled cubic nanoparticles (functional 3D nano structures) in solution:
Wang et al. reported growth of Fe3O4 nanowires induced by the magnetic field.[38] Subsequently, Taheri et al. reported the discovery of an interesting magnetic field–induced self-assembled phenomenon of cubic nanoparticles (NPs) in solution (Figures 1(A)–1(E)).
…In addition, the magnetic field also shows their great ability in NPs’ assembly. Magnetic field–induced self-assembly simplifies the operation steps, but requires accurate magnetic field control equipment to achieve, which increases the dependence on the equipment.
What’s clear from this analysis is that external magnetic fields can direct the self-assembly of nanostructures which can function as cybernetic biocircuity interface systems in the human body.
The paper explains:
This approach could be used for the assembling process of other MNPs such as Ni NPs, Co NPs, and Fe3O4 NPs. Such self-assembly strategy might play an important role in the construction of DDSs. (Drug Delivery Systems)
Additionally, the paper makes reference to self-assembled cubic nanoparticles (functional 3D nano structures) in solution:
Wang et al. reported growth of Fe3O4 nanowires induced by the magnetic field.[38] Subsequently, Taheri et al. reported the discovery of an interesting magnetic field–induced self-assembled phenomenon of cubic nanoparticles (NPs) in solution (Figures 1(A)–1(E)).
…In addition, the magnetic field also shows their great ability in NPs’ assembly. Magnetic field–induced self-assembly simplifies the operation steps, but requires accurate magnetic field control equipment to achieve, which increases the dependence on the equipment.
What’s clear from this analysis is that external magnetic fields can direct the self-assembly of nanostructures which can function as cybernetic biocircuity interface systems in the human body.
The self-assembly of iron oxide nanowires:
Another study published in 2004 in the journal Advanced Materials shows some of the early research in self-assembly of iron oxide nanowires using external magnetic fields.
See: Magnetic-Field-Induced Growth of Single-Crystalline Fe3O4 Nanowires (https://onlinelibrary.wiley.com/doi/10.1002/adma.200306136)
Single-crystalline nanowires of Fe3O4 hydrothermally synthesized under a magnetic field are reported. The square and hexagonal crystals formed in zero applied field are shown to give way to nanowires as the magnetic field is increased.
That was 17 years ago.
What researchers have discovered since then is that the required energy to initiate self-assembly is surprisingly small. From the first paper, above:
The interaction between the induced magnetic dipole and the external field was very weak, which was on the order of van der Waals force. The past decades have witnessed the progress of the self-assembly of MNMs under magnetic fields.
What this means, essentially, is that relatively weak broadcast energies can induce the growth of nanowires inside the human body, given the right substances being injected into the body to start with. The van der Waals force describes a very weak intermolecular bonding phenomenon that’s well known in mainstream science.
Here’s an electronic microscopy image of some of the nanoparticle lattices created through external magnetic fields:
Another study published in 2004 in the journal Advanced Materials shows some of the early research in self-assembly of iron oxide nanowires using external magnetic fields.
See: Magnetic-Field-Induced Growth of Single-Crystalline Fe3O4 Nanowires (https://onlinelibrary.wiley.com/doi/10.1002/adma.200306136)
Single-crystalline nanowires of Fe3O4 hydrothermally synthesized under a magnetic field are reported. The square and hexagonal crystals formed in zero applied field are shown to give way to nanowires as the magnetic field is increased.
That was 17 years ago.
What researchers have discovered since then is that the required energy to initiate self-assembly is surprisingly small. From the first paper, above:
The interaction between the induced magnetic dipole and the external field was very weak, which was on the order of van der Waals force. The past decades have witnessed the progress of the self-assembly of MNMs under magnetic fields.
What this means, essentially, is that relatively weak broadcast energies can induce the growth of nanowires inside the human body, given the right substances being injected into the body to start with. The van der Waals force describes a very weak intermolecular bonding phenomenon that’s well known in mainstream science.
Here’s an electronic microscopy image of some of the nanoparticle lattices created through external magnetic fields:
Wiley Online Library
Magnetic‐Field‐Induced Growth of Single‐Crystalline Fe3O4 Nanowires
Single-crystalline nanowires of Fe3O4 hydrothermally synthesized under a magnetic field are reported. The square and hexagonal crystals formed in zero applied field are shown to give way to nanowires...
Magnetically controllable DNA hydrogels:
The same study also mentions “DNA hydrogels,” explaining that they are “magnetically controllable.” From the study: (emphasis added)
DNA is considered as a core genetic biological molecule in living systems. Although DNA molecules are composed of simple units, different deoxynucleotide chains and flexible conformations can be achieved through precise design and organization, which can be programmed. In other words, this is the nature of DNA self-assembly. For example, Ma et al. introduced DNA-modified MNPs, Y-scaffolds, and DNA linkers into the framework of DNA hydrogels to construct magnetic controllable DNA hydrogels.
If you’re wondering what “DNA hydrogels” are all about, another paper published in 2019 reveals some clues: DNA hydrogel-empowered biosensing (https://pubmed.ncbi.nlm.nih.gov/31739981/)
That paper explains how “smart hydrogels” self-modify in response to the organism:
DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored DNA hydrogels for various applications in drug delivery, tissue engineering, sensors, and cancer therapy.
Recently, DNA-based materials have attracted substantial consideration for the exploration of smart hydrogels, in which their properties can change in response to chemical or physical stimuli. In other words, these gels can undergo switchable gel-to-sol or sol-to-gel transitions upon application of different triggers. Moreover, various functional motifs like i-motif structures, antisense DNAs, DNAzymes, and aptamers can be inserted into the polymer network to offer a molecular recognition capability to the complex. In this manuscript, a comprehensive discussion will be endowed with the recognition capability of different kinds of DNA hydrogels and the alternation in physicochemical behaviors upon target introducing.
Once these nanostructures are assembled inside the body, they are controlled through external magnetic fields or electromagnetic broadcasts, requiring very little power.
The same study also mentions “DNA hydrogels,” explaining that they are “magnetically controllable.” From the study: (emphasis added)
DNA is considered as a core genetic biological molecule in living systems. Although DNA molecules are composed of simple units, different deoxynucleotide chains and flexible conformations can be achieved through precise design and organization, which can be programmed. In other words, this is the nature of DNA self-assembly. For example, Ma et al. introduced DNA-modified MNPs, Y-scaffolds, and DNA linkers into the framework of DNA hydrogels to construct magnetic controllable DNA hydrogels.
If you’re wondering what “DNA hydrogels” are all about, another paper published in 2019 reveals some clues: DNA hydrogel-empowered biosensing (https://pubmed.ncbi.nlm.nih.gov/31739981/)
That paper explains how “smart hydrogels” self-modify in response to the organism:
DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored DNA hydrogels for various applications in drug delivery, tissue engineering, sensors, and cancer therapy.
Recently, DNA-based materials have attracted substantial consideration for the exploration of smart hydrogels, in which their properties can change in response to chemical or physical stimuli. In other words, these gels can undergo switchable gel-to-sol or sol-to-gel transitions upon application of different triggers. Moreover, various functional motifs like i-motif structures, antisense DNAs, DNAzymes, and aptamers can be inserted into the polymer network to offer a molecular recognition capability to the complex. In this manuscript, a comprehensive discussion will be endowed with the recognition capability of different kinds of DNA hydrogels and the alternation in physicochemical behaviors upon target introducing.
Once these nanostructures are assembled inside the body, they are controlled through external magnetic fields or electromagnetic broadcasts, requiring very little power.
PubMed
DNA hydrogel-empowered biosensing - PubMed
DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored…
What this research demonstrates is that:
Self-assembling nanotechnology is real.
Biocircuitry interface nanotech is real.
The nanowires and nanocircuits can be controlled by external electromagnetic fields.
This tech has been studied and developed for at least two decades and is backed by a large body of published research. It is therefore feasible for today’s “vaccines” to contain self-assembling nanotechnology that interfaces with human biology and is controlled by external broadcasts. This doesn’t prove that such a scenario is happening for certain, but it shows that the tech exists and is feasible.
If you’re still not convinced, consider this text from a study published nearly a decade ago, in December of 2012:
Superparamagnetic Iron Oxide Nanoparticle-Based Delivery Systems for Biotherapeutics (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167583/)
This review covers recently-developed magnetically-driven delivery systems, their unique characteristics, and their applicability for delivery of biotherapeutics. Since methods for synthesis of SPIONs and use of SPIONs as MRI contrast agents for diagnosis have been extensively reviewed [18, 19], this review focuses on the SPION-based formulations that are specific to delivery of biotherapeutics. Magnetic nanoparticles dispersed in organic solvent and aqueous solutions can be loaded within liposomes, micelles, hydrogels, and micro/nanospheres during formulation.
"First, we examine recent formulation strategies for modification of SPIONs including particle clustering and encapsulation within hydrogels, liposomes, micelles, and micro-/nano-spheres. Second, we discuss the considerations to be taken into account in design of SPION-based carriers for the delivery of specific biotherapeutics including cells, proteins/peptides, genes, and viruses. Further, we examine several commercial magnetic nanoparticles for delivery of biotherapeutics. Finally, we provide perspectives in the future directions of magnetically triggered, SPION-based carriers for biotherapeutics, and their potential clinical applications."
That was nearly a decade ago. Imagine what has been developed and deployed in the years since.
Self-assembling nanotechnology is real.
Biocircuitry interface nanotech is real.
The nanowires and nanocircuits can be controlled by external electromagnetic fields.
This tech has been studied and developed for at least two decades and is backed by a large body of published research. It is therefore feasible for today’s “vaccines” to contain self-assembling nanotechnology that interfaces with human biology and is controlled by external broadcasts. This doesn’t prove that such a scenario is happening for certain, but it shows that the tech exists and is feasible.
If you’re still not convinced, consider this text from a study published nearly a decade ago, in December of 2012:
Superparamagnetic Iron Oxide Nanoparticle-Based Delivery Systems for Biotherapeutics (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167583/)
This review covers recently-developed magnetically-driven delivery systems, their unique characteristics, and their applicability for delivery of biotherapeutics. Since methods for synthesis of SPIONs and use of SPIONs as MRI contrast agents for diagnosis have been extensively reviewed [18, 19], this review focuses on the SPION-based formulations that are specific to delivery of biotherapeutics. Magnetic nanoparticles dispersed in organic solvent and aqueous solutions can be loaded within liposomes, micelles, hydrogels, and micro/nanospheres during formulation.
"First, we examine recent formulation strategies for modification of SPIONs including particle clustering and encapsulation within hydrogels, liposomes, micelles, and micro-/nano-spheres. Second, we discuss the considerations to be taken into account in design of SPION-based carriers for the delivery of specific biotherapeutics including cells, proteins/peptides, genes, and viruses. Further, we examine several commercial magnetic nanoparticles for delivery of biotherapeutics. Finally, we provide perspectives in the future directions of magnetically triggered, SPION-based carriers for biotherapeutics, and their potential clinical applications."
That was nearly a decade ago. Imagine what has been developed and deployed in the years since.
PubMed Central (PMC)
Superparamagnetic Iron Oxide Nanoparticle-Based Delivery Systems for Biotherapeutics
Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable, and superparamagnetic and thus controllable by an external magnetic…
https://www.nejm.org/doi/full/10.1056/NEJMoa2109908
"Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a new syndrome associated with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory syndrome coronavirus 2."
"Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a new syndrome associated with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory syndrome coronavirus 2."
The New England Journal of Medicine
Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis | NEJM
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a new syndrome associated
with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory
syndrome coronavirus 2...
with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory
syndrome coronavirus 2...
Delivery and formulation of engineered nucleic acids
Patent CA2831613A1
filed by: Moderna Therapeutics Inc
Status: Pending
https://patents.google.com/patent/CA2831613A1/en
"The invention relates to delivery methods. These methods are specifically useful in therapeutic delivery of modified nucleic acids such as modified mRNA (mmRNA)."
"There are multiple problems with prior methodologies of deliverying pharmaceutical compositions in order to achieve effective protein expression both for therapeutics and bioprocessing applications. For example, introduced DNA can integrate into host cell genomic DNA at some frequency, resulting in alterations and/or damage to the host cell genomic DNA.
Alternatively, the heterologous deoxyribonucleic acid (DNA) introduced into a cell can be inherited by daughter cells (whether or not the heterologous DNA has integrated into the chromosome) or by offspring.
In addition, there are multiple steps which must occur after delivery but before the encoded protein is made which can effect protein expression. Once inside the cell, DNA must be transported into the nucleus where it is transcribed into RNA. The RNA transcribed from DNA must then enter the cytoplasm where it is translated into protein. Not only do the multiple processing steps from administered DNA to protein create lag times before the generation of the functional protein, each step represents an opportunity for error and and damage to the cell.
Further, it is known to be difficult to obtain DNA expression in cells as frequently DNA enters a cell but is not expressed or not expressed at reasonable rates or concentrations. This can be a particular problem when DNA is introduced into primary cells or modified cell lines."
Patent CA2831613A1
filed by: Moderna Therapeutics Inc
Status: Pending
https://patents.google.com/patent/CA2831613A1/en
"The invention relates to delivery methods. These methods are specifically useful in therapeutic delivery of modified nucleic acids such as modified mRNA (mmRNA)."
"There are multiple problems with prior methodologies of deliverying pharmaceutical compositions in order to achieve effective protein expression both for therapeutics and bioprocessing applications. For example, introduced DNA can integrate into host cell genomic DNA at some frequency, resulting in alterations and/or damage to the host cell genomic DNA.
Alternatively, the heterologous deoxyribonucleic acid (DNA) introduced into a cell can be inherited by daughter cells (whether or not the heterologous DNA has integrated into the chromosome) or by offspring.
In addition, there are multiple steps which must occur after delivery but before the encoded protein is made which can effect protein expression. Once inside the cell, DNA must be transported into the nucleus where it is transcribed into RNA. The RNA transcribed from DNA must then enter the cytoplasm where it is translated into protein. Not only do the multiple processing steps from administered DNA to protein create lag times before the generation of the functional protein, each step represents an opportunity for error and and damage to the cell.
Further, it is known to be difficult to obtain DNA expression in cells as frequently DNA enters a cell but is not expressed or not expressed at reasonable rates or concentrations. This can be a particular problem when DNA is introduced into primary cells or modified cell lines."
Commonalities Between COVID-19 and Radiation Injury
https://meridian.allenpress.com/radiation-research/article/195/1/1/446280/Commonalities-Between-COVID-19-and-Radiation
https://meridian.allenpress.com/radiation-research/article/195/1/1/446280/Commonalities-Between-COVID-19-and-Radiation