• Memory Retention in Frozen Organisms: Encouragingly, there is evidence that information encoded in the brain can survive cryopreservation. A 2015 study demonstrated that nematode worms (C. elegans) retained learned behaviors after being vitrified and re-warmed. Worms trained to associate a smell with food still responded to that odor after recovery from cryopreservation, indicating that their neural memory traces were not erased by the process . This implies that synaptic changes underlying memory can endure vitrification in a simple animal model, supporting the idea that a human brain’s memories could likewise remain intact if its structure is well-preserved.
• Organ Vitrification and Revival: Outside the brain, progress in organ cryopreservation also bolsters cryonics plausibility. Researchers have vitrified whole organs and then successfully revived them with function, a key step toward “reversible” freezing. Notably, a rabbit kidney vitrified with cryoprotectant was later transplanted into a rabbit, restoring life-sustaining renal function for weeks . More recently (2023), scientists vitrified rat kidneys and used an innovative nanowarming technique – heating the organ rapidly and uniformly via nanoparticles in the tissue – to rewarm without crystallization or cracking, enabling successful transplantation. The reanimated kidneys functioned normally in rats after long-term cryogenic storage . This is the first repeated, peer-reviewed demonstration of a vital organ being cryopreserved and revived to full function, marking a major milestone on the road to reversible cryopreservation .
• Revival of Brain Tissue Samples: Just this year, a team in Germany revived preserved brain tissue, offering a proof-of-concept for restoring neural function after cryopreservation. They optimized a vitrification protocol for mouse hippocampal slices (brain tissue) using a cocktail of cryoprotectants and fast cooling to avoid ice. Critically, after rewarming, the brain slices not only appeared intact but also regained electrophysiological function: they showed normal electrical activity and even long-term potentiation (LTP), a memory-related neural process . This is the first time adult brain tissue has been cryopreserved and then shown to resume functional activity . While these were small slices (hundreds of microns thick) and not a whole brain, it demonstrates reversible cryopreservation on a tissue level – a remarkable technical advance.

Mood

Why do I even care about the long term?

if markets are efficient, who is shorting MOEX on a nuclear war threats?

just arrived. any guesses where?

https://recordcrash.substack.com/p/book-review-avant-garde-autopilot
AGARES review with some great Alexander Wales writers career overview!

I posted nothing about Barca trip because i’m having such a blast that I just have no time to post anything

so I wish yall that, be happy.

Days since the last emotional breakdown: 0.

I will bulldoze through every obstacly standing in my way to happiness.
I will only allow the world to be unfair as long as it is to my advantages.
I will not stop until I stand at the very peak of whatever mountain my gaze lands upon.
I will shape the universe to my will and tear up the stars if it needs to be done.
I will not stop until I am satisfied with what I achieved and reached my potential.
I will not be an NPC in my own story, rest be damned.

This is my mantra and I will repeat it until it becomes the Truth.
Behold.

https://youtu.be/Bm3YWNgpgP0
Someone in the comments said:
"He knows.
They know he knows.
He knows they know he knows.”
This is wrong tho, actual truth is more like:
"He knows.
They are 90% sure he knows.
He knows they’re not 100% sure he knows so he is banking on them hoping he doesn’t know (because what other choice do they have?)."

He makes sure to give them outs however ridiculous they are, he doesn’t want them to get to the 100%, that would make situation harder to control.

You will see this shot in memes for the next 15 years

SAM ALTMAN:
“A kid born today will never be smarter than AI ever. And a kid born today, by the time that kid understands the way the world works, will just always be used to an incredibly fast rate of things improving and discovering new science. They’ll just, they will never know any other world. It will seem totally natural. It will seem unthinkable and stone age that we used to use computers or phones or any kind of technology that was not way smarter than we were. We will think how bad those people of the 2020s had it.”

Everyone with a TV set had seen Hell, but no one knew if there was a Heaven. They only knew that there was a crack in the sky, and that Neil Armstrong had passed through it singing songs of praise for the Most High.
But no one had ever known if there was a Heaven, and that hadn’t stopped them from hoping.
For example, Richard Nixon. Richard Nixon knew he probably wasn’t going to get into Heaven the traditional way, so he’d pulled rank and got himself a ticket on a space capsule to enter it directly. Unfortunately for him, that space capsule had been Apollo 13, and he’d fallen back to Earth and his enraged constituents. But what if he’d had the right idea?
At age 35, business magnate Richard Branson was already head of Virgin Records, Virgin Communications, Virgin Games, and Virgin Atlantic Airways. What other people saw as the immutable will of God he saw as a business opportunity. So he teamed up with legendary aerospace engineer Burt Rutan to create a spacecraft capable of transporting a small number of lucky passengers up into the crack. And by lucky, he meant “very very rich”. If you can’t take it with you, you might as well give it to the people promising to ensure you an afterlife of eternal bliss.
Thus was born Celestial Virgin. Jesus had said it was easier for a camel to pass through the eye of a needle than for a rich man to enter Heaven, but rocketry had thirty years of practice working with astonishingly small tolerances and rose to meet the challenge. Competitors sprung up – HeavenX, Blue Origen – but if you really wanted the best engineers in the world aiming you at that needle eye and guaranteeing you’d get through, you would petition Celestial Virgin, accept no substitutes.
Sure, there were people saying it was literally the most blasphemous thing possible – to sell the rich tickets to Heaven so that only the poor had to answer for their misdeeds. But there were always people saying that kind of stuff. Why, you could say it was wrong to have doctors, because then rich people had an advantage in surviving disease! You could say it was wrong to have bookstores, because then rich people had an advantage in learning about the world! Everyone important, ie rich, was happy to ignore these nattering nabobs of negativism, and when Celestial Virgin offered to buy the Kennedy Space Center from the cash-strapped Untied States government, President Reagan was quick to agree.

Unsong