❇️Topotecan is used in metastatic ovarian cancer when primary therapy has failed and also in the treatment of small cell lung cancer.
❇️Irinotecan is used with 5-FU
and leucovorin for the treatment of colorectal carcinoma.
❇️Irinotecan is used with 5-FU
and leucovorin for the treatment of colorectal carcinoma.
ملخص الكيموثربي كامل.pdf
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ملخص لجميع محاضرات الكيموثربي 🧬
اهم شي بالكيموثربي ❗️
العلاج المن تابع + الميكانزم + الاستخدام المميز ( يعني يعالج نوع من الكانسر ما تعالجه باقي العلاجات ) + الاثار الضارة الشائعة والمميزة ( مثل السمية القلبية )
اعداد الطالب : صادق علي 📚
#cancer
اهم شي بالكيموثربي ❗️
العلاج المن تابع + الميكانزم + الاستخدام المميز ( يعني يعالج نوع من الكانسر ما تعالجه باقي العلاجات ) + الاثار الضارة الشائعة والمميزة ( مثل السمية القلبية )
اعداد الطالب : صادق علي 📚
#cancer
اسئلة فقط لتثبيت المعلومة حول anti inflammatory drugs
(يعني عادي اذا معرفتوها )
سؤال 1 : ليش diflunisal ماعنده تأثير antipyretic ؟
لان ميكدر يعبر bbb
سؤال 2 : ليش nabutamone و sulnidac الوحيدين الي ميتحولون الى inactive metabolites ؟
لان همَ prodrug (خارجي )
سؤال 3 :
Agents with higher relative COX-2 selectivity have been associated with an increased risk for cardiovascular events, possibly by...............
decreasePG I2
(يعني عادي اذا معرفتوها )
سؤال 1 : ليش diflunisal ماعنده تأثير antipyretic ؟
سؤال 2 : ليش nabutamone و sulnidac الوحيدين الي ميتحولون الى inactive metabolites ؟
سؤال 3 :
Agents with higher relative COX-2 selectivity have been associated with an increased risk for cardiovascular events, possibly by...............
decrease
سؤال4 :
severe salicylate intoxication may result . Restlessness, delirium, hallucinations, convulsions, coma, respiratory and metabolic acidosis, and death from ........ may occur.
respiratory failure
سؤال5:
Approximately 15% of patients taking aspirin experience hypersensitivity reactions. Symptoms of true allergy include .............
urticaria, bronchoconstriction, and angioedema
سؤال6:
Mild salicylate toxicity is called......
salicylism
سؤال7:
For patients with cardiovascular disease in whom NSAID treatment cannot be avoided, ............ may be the least likely to be harmful
naproxen
سؤال8 :
antidote of paracetamol toxicity is .........
acetylcysteine
سؤال 9:
Glomeruli and arterioles synthesize not only the vasodilatory prostaglandins PGE2 and PGI2, but also the vasoconstrictor, ..........
TXA2
سوال10:
An increased risk for cardiovascular events, including MI and stroke, has been associated with all NSAIDs except ......
aspirin
سؤال11 :
celecoxib is extensively metabolized in the liver by ........
CYP2c9
Inhibitors of CYP2C9, such as ............, may increase serum levels of celecoxib.
fluconazole
severe salicylate intoxication may result . Restlessness, delirium, hallucinations, convulsions, coma, respiratory and metabolic acidosis, and death from ........ may occur.
سؤال5:
Approximately 15% of patients taking aspirin experience hypersensitivity reactions. Symptoms of true allergy include .............
سؤال6:
Mild salicylate toxicity is called......
سؤال7:
For patients with cardiovascular disease in whom NSAID treatment cannot be avoided, ............ may be the least likely to be harmful
سؤال8 :
antidote of paracetamol toxicity is .........
سؤال 9:
Glomeruli and arterioles synthesize not only the vasodilatory prostaglandins PGE2 and PGI2, but also the vasoconstrictor, ..........
سوال10:
An increased risk for cardiovascular events, including MI and stroke, has been associated with all NSAIDs except ......
سؤال11 :
celecoxib is extensively metabolized in the liver by ........
Inhibitors of CYP2C9, such as ............, may increase serum levels of celecoxib.
Traditional DMARDs.pdf
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ملخص موضوع #DMARDتكدرون تعتمدون عليه
اسئلة فقط لتثبيت المعلومة حول adrenal hormones lec7
سوال1: منو الدواء الي يثبط sod&water reabsorption & فعال في liver cirrhosis ؟
spironolactone
سوال2:
The half-life of corticosteroids may increase substantially in ...........
hepatic dysfunction
سؤال3:
When large doses of corticosteroids are required for more than ......weeks, suppression of the HPA axis occurs.
2
سؤال4:
Increased appetite is not necessarily an adverse effect of corticosteroids. In fact, it is one of the reasons for the use of .......... in cancer
prednisone
سؤال5:
Alternate-day administration of corticosteroids may prevent this adverse effect by .....
allowing HPA axis to recover
سؤال6:
Topical therapy of corticosteroids can cause ..........
skin atrophy, ecchymosis, and purple striae
سؤال7:
.........is the most common adverse effect of corticosteroids.
osteoporosis
سؤال8 :
hydrocortisone can cause osteoporosis by .........
suppress intestinal absorption of Ca
سوال1: منو الدواء الي يثبط sod&water reabsorption & فعال في liver cirrhosis ؟
سوال2:
The half-life of corticosteroids may increase substantially in ...........
سؤال3:
When large doses of corticosteroids are required for more than ......weeks, suppression of the HPA axis occurs.
سؤال4:
Increased appetite is not necessarily an adverse effect of corticosteroids. In fact, it is one of the reasons for the use of .......... in cancer
سؤال5:
Alternate-day administration of corticosteroids may prevent this adverse effect by .....
سؤال6:
Topical therapy of corticosteroids can cause ..........
سؤال7:
.........is the most common adverse effect of corticosteroids.
سؤال8 :
hydrocortisone can cause osteoporosis by .........
Probenecid blocks proximal tubular reabsorption of uric acid.
Vasopressin and densopressin are increase water reabsorption only in the collecting tubule
Mineralocorticoid increases water & Na & HCO3 reabsorption in the distal tubules and collecting ducts
SGLT2-I inhibit reabsorbing glucose in the tubular lumen of the kidney
also decreases reabsorption of Na
Vasopressin and densopressin are increase water reabsorption only in the collecting tubule
Mineralocorticoid increases water & Na & HCO3 reabsorption in the distal tubules and collecting ducts
SGLT2-I inhibit reabsorbing glucose in the tubular lumen of the kidney
also decreases reabsorption of Na
اسئلة lec4 osteoporosis
1. which osteoporosis medication can cause adverse effects e.g rhinitis and other nasal symptoms.......
calcitonin
2. regarding parathyroid agent , ......... is a recombinant form of human parathyroid hormone and .......... is an analog of parathyroid hormone-related peptide
Teriparatide then abaloparatide
3.regarding Treatment of osteoporosis, ......... cause hypocalcemia & ...... cause hypercalcemia orthostatic hypotension.
denosumab ,then Teriparatide&abaloparatide
4.current guidelines recommend a drug holiday for some patients after .... years of oral bisphosphonates or .... years of zoledronic acid.
5 then 3
5. denosumab is administered via subcutaneous injection every ......
6 months
6............ is considered a first-line agent for osteoporosis, particularly in patients at higher risk of fractures.
Denosumab
7. The risk of atypical fractures seems to increase with long-term use of bisphosphonates like .....
jew & femur fracture
8.Cumulative lifetime use of ..... agent for more than 2 years is not recommended.
parathyroid agents
9.Bisphosphonates including ....... are preferred agents for treatment of postmenopausal osteoporosis.
alendronate, risedronate, and zoledronic acid
10.Osteomalacia in children is referred to as .....
rickets
11. treatment of osteomalacia
vit D3 & ca
1. which osteoporosis medication can cause adverse effects e.g rhinitis and other nasal symptoms.......
2. regarding parathyroid agent , ......... is a recombinant form of human parathyroid hormone and .......... is an analog of parathyroid hormone-related peptide
3.regarding Treatment of osteoporosis, ......... cause hypocalcemia & ...... cause hypercalcemia orthostatic hypotension.
4.current guidelines recommend a drug holiday for some patients after .... years of oral bisphosphonates or .... years of zoledronic acid.
5. denosumab is administered via subcutaneous injection every ......
6............ is considered a first-line agent for osteoporosis, particularly in patients at higher risk of fractures.
7. The risk of atypical fractures seems to increase with long-term use of bisphosphonates like .....
8.Cumulative lifetime use of ..... agent for more than 2 years is not recommended.
9.Bisphosphonates including ....... are preferred agents for treatment of postmenopausal osteoporosis.
10.Osteomalacia in children is referred to as .....
11. treatment of osteomalacia
anticancer
antimetabolites ➡️ S phase
Anthracycline ➡️ nonspecific
bleomycine➡️ G2 phase
VX,VBL➡️ M phase
Paclitaxel,Docetaxel➡️ G2/M phase
Cisplatin ➡️ G1/S phase
topetecan,Irinotecan ➡️ S phase
Etoposide ➡️ G2/S phase
antimetabolites ➡️ S phase
Anthracycline ➡️ nonspecific
bleomycine➡️ G2 phase
VX,VBL➡️ M phase
Paclitaxel,Docetaxel➡️ G2/M phase
Cisplatin ➡️ G1/S phase
topetecan,Irinotecan ➡️ S phase
Etoposide ➡️ G2/S phase
هواي جتني اسئلة على prandial , postprandial
ثنيهم نفضللهم الانسولين سريع المفعول rapid-shot او الادوية الفموية الي تكون سريعه المفعول
زين شنو الفرق بينهم ؟
الـ prandial معناها وقت الاكل راح يصعد الانسولين بصوره جبيرة (burst )
والـ postprandial معناها بعد الاكل بس بفترة مو طويلة ، الانسولين هم حيصعد مستوى بس بصوره مو كلش جبيرة
اما الادوية الي يكون مفعولها طويل معليها بالـ prandial (يعني معليها بالاكل) هاي راح تسوي cover للـ fasting state ، يعني بعد الاكل بفترة طويللة
ثنيهم نفضللهم الانسولين سريع المفعول rapid-shot او الادوية الفموية الي تكون سريعه المفعول
زين شنو الفرق بينهم ؟
الـ prandial معناها وقت الاكل راح يصعد الانسولين بصوره جبيرة (burst )
والـ postprandial معناها بعد الاكل بس بفترة مو طويلة ، الانسولين هم حيصعد مستوى بس بصوره مو كلش جبيرة
اما الادوية الي يكون مفعولها طويل معليها بالـ prandial (يعني معليها بالاكل) هاي راح تسوي cover للـ fasting state ، يعني بعد الاكل بفترة طويللة