⚠️Cyclophosphamide is available in oral and IV preparations, whereas ifosfamide is IV only.

❇️VBL (vinblastine)is administered with
bleomycin and cisplatin for the treatment of metastatic testicular carcinoma

❇️Tamoxifen is used for first-line therapy in the treatment of estrogen receptor–positive breast cancer. It is also used for prevention of breast cancer in high-risk women.

❇️Topotecan is used in metastatic ovarian cancer when primary therapy has failed and also in the treatment of small cell lung cancer.

❇️Irinotecan is used with 5-FU
and leucovorin for the treatment of colorectal carcinoma.

ملخص لجميع محاضرات الكيموثربي 🧬

اهم شي بالكيموثربي ❗️

العلاج المن تابع + الميكانزم + الاستخدام المميز ( يعني يعالج نوع من الكانسر ما تعالجه باقي العلاجات ) + الاثار الضارة الشائعة والمميزة ( مثل السمية القلبية )

اعداد الطالب : صادق علي 📚
#cancer

اسئلة فقط لتثبيت المعلومة حول anti inflammatory drugs
(يعني عادي اذا معرفتوها )

سؤال 1 : ليش diflunisal ماعنده تأثير antipyretic ؟
لان ميكدر يعبر bbb

سؤال 2 : ليش nabutamone و sulnidac الوحيدين الي ميتحولون الى inactive metabolites ؟
لان همَ prodrug (خارجي )

سؤال 3 :
Agents with higher relative COX-2 selectivity have been associated with an increased risk for cardiovascular events, possibly by...............

decrease PG I2

سؤال4 :
severe salicylate intoxication may result . Restlessness, delirium, hallucinations, convulsions, coma, respiratory and metabolic acidosis, and death from ........ may occur.
respiratory failure

سؤال5:
Approximately 15% of patients taking aspirin experience hypersensitivity reactions. Symptoms of true allergy include .............
urticaria, bronchoconstriction, and angioedema

سؤال6:
Mild salicylate toxicity is called......
salicylism

سؤال7:
For patients with cardiovascular disease in whom NSAID treatment cannot be avoided, ............ may be the least likely to be harmful
naproxen

سؤال8 :
antidote of paracetamol toxicity is .........
acetylcysteine

سؤال 9:
Glomeruli and arterioles synthesize not only the vasodilatory prostaglandins PGE2 and PGI2, but also the vasoconstrictor, ..........
TXA2

سوال10:
An increased risk for cardiovascular events, including MI and stroke, has been associated with all NSAIDs except ......
aspirin

سؤال11 :
celecoxib is extensively metabolized in the liver by ........
CYP2c9

Inhibitors of CYP2C9, such as ............, may increase serum levels of celecoxib.
fluconazole

موضوع osteoporosis
هاي الارقام تنحفظ لان جاي عليها سؤال بسنة 2022 واحتمال يتكرر