⚠️Cyclophosphamide is available in oral and IV preparations, whereas ifosfamide is IV only.

❇️VBL (vinblastine)is administered with
bleomycin and cisplatin for the treatment of metastatic testicular carcinoma

❇️Tamoxifen is used for first-line therapy in the treatment of estrogen receptor–positive breast cancer. It is also used for prevention of breast cancer in high-risk women.

❇️Topotecan is used in metastatic ovarian cancer when primary therapy has failed and also in the treatment of small cell lung cancer.

❇️Irinotecan is used with 5-FU
and leucovorin for the treatment of colorectal carcinoma.

ملخص لجميع محاضرات الكيموثربي 🧬

اهم شي بالكيموثربي ❗️

العلاج المن تابع + الميكانزم + الاستخدام المميز ( يعني يعالج نوع من الكانسر ما تعالجه باقي العلاجات ) + الاثار الضارة الشائعة والمميزة ( مثل السمية القلبية )

اعداد الطالب : صادق علي 📚
#cancer

اسئلة فقط لتثبيت المعلومة حول anti inflammatory drugs
(يعني عادي اذا معرفتوها )

سؤال 1 : ليش diflunisal ماعنده تأثير antipyretic ؟
لان ميكدر يعبر bbb

سؤال 2 : ليش nabutamone و sulnidac الوحيدين الي ميتحولون الى inactive metabolites ؟
لان همَ prodrug (خارجي )

سؤال 3 :
Agents with higher relative COX-2 selectivity have been associated with an increased risk for cardiovascular events, possibly by...............

decrease PG I2

سؤال4 :
severe salicylate intoxication may result . Restlessness, delirium, hallucinations, convulsions, coma, respiratory and metabolic acidosis, and death from ........ may occur.
respiratory failure

سؤال5:
Approximately 15% of patients taking aspirin experience hypersensitivity reactions. Symptoms of true allergy include .............
urticaria, bronchoconstriction, and angioedema

سؤال6:
Mild salicylate toxicity is called......
salicylism

سؤال7:
For patients with cardiovascular disease in whom NSAID treatment cannot be avoided, ............ may be the least likely to be harmful
naproxen

سؤال8 :
antidote of paracetamol toxicity is .........
acetylcysteine

سؤال 9:
Glomeruli and arterioles synthesize not only the vasodilatory prostaglandins PGE2 and PGI2, but also the vasoconstrictor, ..........
TXA2

سوال10:
An increased risk for cardiovascular events, including MI and stroke, has been associated with all NSAIDs except ......
aspirin

سؤال11 :
celecoxib is extensively metabolized in the liver by ........
CYP2c9

Inhibitors of CYP2C9, such as ............, may increase serum levels of celecoxib.
fluconazole