⚠️Methotrexate is contraindicated in pregnancy.

✳️Leflunomide is an immune-modulatory agent, causes cell arrest of the autoimmune lymphocytes through its action on dihydroorotate dehydrogenase (DHODH),

⚠️Leflunomide is contraindicated in pregnancy.

🤰🏻Acetaminophen is preferred if analgesic or antipyretic effects are needed during pregnancy

❇️Acetaminophen is the analgesic/antipyretic of choice for children with viral infections or chickenpox (due to the risk of Reye syndrome with aspirin).

⚠️⚠️🤰🏻In the third trimester, NSAIDs should generally be avoided due to the risk of premature closure of the ductus arteriosus.

❇️Rituximab is administered
as an intravenous infusion every 16 to 24 weeks.