❇️⚠️NSAIDs should be taken with food or fluids to diminish GI upset. If NSAIDs are used in patients at high risk for GI events, proton pump inhibitors or misoprostol should be used concomitantly to prevent NSAID-induced ulcers.
✳️Concomitant use of NSAIDs and aspirin can prevent aspirin from binding to cyclooxygenase. Patients who take aspirin for cardioprotection should avoid
concomitant NSAID use if possible or take aspirin at least 30 minutes prior to the NSAID.
concomitant NSAID use if possible or take aspirin at least 30 minutes prior to the NSAID.
⚠️⚠️NSAIDs should be used
with caution in patients with asthma, as inhibition of prostaglandin synthesis can
cause a shift toward leukotriene production and increase the risk of asthma exacerbations.
with caution in patients with asthma, as inhibition of prostaglandin synthesis can
cause a shift toward leukotriene production and increase the risk of asthma exacerbations.
❇️Mild salicylate toxicity is called salicylism and is characterized by nausea, vomiting, marked hyperventilation, headache, mental confusion, dizziness, and tinnitus (ringing or roaring in the ears).
👶🏻🧑🏻Children are particularly prone to salicylate intoxication; ingestion of as little as 10 g of aspirin can be fatal.
✳️Mainstay of treatment in patients with rheumatoid or psoriatic arthritis.Response to
methotrexate occurs within 3 to 6 weeks of starting treatment.
methotrexate occurs within 3 to 6 weeks of starting treatment.
✳️Leflunomide is an immune-modulatory agent, causes cell arrest of the autoimmune lymphocytes through its action on dihydroorotate dehydrogenase (DHODH),
🤰🏻Acetaminophen is preferred if analgesic or antipyretic effects are needed during pregnancy
❇️Acetaminophen is the analgesic/antipyretic of choice for children with viral infections or chickenpox (due to the risk of Reye syndrome with aspirin).
⚠️⚠️🤰🏻In the third trimester, NSAIDs should generally be avoided due to the risk of premature closure of the ductus arteriosus.