Note s4
121 subscribers
329 photos
69 files
77 links
Download Telegram
دتستفادون من قناة😶🌫
2
text about Filter Aids:


---

1. What is the primary function of a filter aid?
A. Increase pore size of the filter medium
B. Reduce the resistance to flow caused by solid accumulation
C. Enhance the chemical reaction in filtration
D. Decrease the porosity of the filter cake
Answer: B


---

2. What happens to the resistance to flow as a solid layer builds up on the filter medium?
A. It remains constant
B. It decreases
C. It increases
D. It fluctuates randomly
Answer: C


---

3. Which type of solids offer higher resistance to flow?
A. Flocculated solids
B. Solids with high porosity
C. Poorly flocculated solids
D. Soluble solids
Answer: C


---

4. In cake filtration, how does the rate vary?
A. Linearly with volume
B. Independently of volume
C. With the square of the volume of liquid
D. With the cube of the volume
Answer: C


---

5. What may happen when the volume of filter cake solids per unit volume of filtrate is low?
A. Filter medium becomes more porous
B. Solids penetrate void spaces, increasing resistance
C. Flow rate increases significantly
D. Filtration stops immediately
Answer: B


---

6. At high concentrations of solids, which phenomenon is more likely?
A. Dissolution of solids
B. Blinding of the openings
C. Bridging over of openings
D. Complete removal of solids
Answer: C


---

7. What happens to the filter medium over time with the accumulation of solids?
A. It becomes clearer
B. It becomes more absorbent
C. It becomes plugged or slimy
D. It remains unaffected
Answer: C




---

1. How does a filter aid ideally act during filtration?
A. By dissolving solids in the liquid
B. By plugging the filter medium
C. By forming a fine surface deposit that screens out solids
D. By compressing the filter cake
Answer: C


---

2. What type of cake does a filter aid usually form?
A. Compressible and dense
B. Porous and non-compressible
C. Slimy and absorbent
D. Impervious and brittle
Answer: B


---

3. Which of the following factors influence the filtration cycle and clarity?
A. Pressure and temperature only
B. Time and volume of filtrate only
C. Density, type, particle size, and quantity of filter aid
D. Concentration of solids only
Answer: C


---

4. What happens if too little filter aid is used?
A. Filtration becomes faster
B. The resistance of the filter cake increases
C. The cake becomes thinner
D. Solids are completely removed
Answer: B


---

5. What is the result of using too much filter aid?
A. Improves filtration speed
B. Reduces cake thickness
C. Adds thickness without improving porosity
D. Completely eliminates resistance
Answer: C


---

6. How are filter aids typically selected?
A. Based on standard values
B. Through computer simulation
C. By trial and error in lab or plant
D. From a universal filter aid list
Answer: C
:

1. What are the two main goals when selecting a filter aid in general applications?
A. Low cost and chemical reactivity
B. Acceptable filtrate and highest flow rate
C. Bright color and fast mixing
D. Maximum thickness and low porosity
Answer: B
2. In pharmaceutical operations, which type of filter aid is usually preferred?
A. Coarse grades with high flow rates
B. Fine grades with low flow rates
C. Absorbent types with color retention
D. Cheap and reactive types
Answer:

3. What is the most important factor for a filter aid in pharmaceutical use?
A. Absorbency
B. Reactivity
C. Inertness
D. Color
Answer: C

4. What can be a negative effect of using highly absorbent filter aids?
A. They increase filtration speed too much
B. They prevent solid separation
C. They may remove desired colored substances and active ingredients
D. They clog the filter instantly
Answer: C

5. Even if the total quantity of an ingredient absorbed by the filter aid is small, why might this be significant?
A. It can cause the cake to collapse
B. It may represent a large proportion of the original concentration
C. It improves the appearance of the filtrate
D. It increases the medium’s porosity
Answer: B
Filter media Summary.pdf
122 KB
Filter media Summary.pdf
#clarification
1
🔥 Rate of drying

A-B \ Initially Adjustment, StaBlizes temp. gradually (Cooling rate = Heating rate)

B \ StaBilized temperature

B-C \ Constant rate period
(Evaporation rate = Diffusion rate)

C \ Critical moisture content (dry spots appear)

C-D \ First falling rate period

D \ Second critical point
(complete evaporation of surface film)

D-E \ Second falling period

E \ Eqiulibrium moisture content (Drying rate = 0)
⚕︎ᚔᚔᚔᚔᚔᚔᚔᚔᚔᚔᚔᚔᚔᚔᚔ⚕︎
@muntedher_Alhussainy
Forwarded from Pharma/Clinical/Therapeutics (Sarmad Pharma🖤)
مهمات كلش بخصوص مادة الصناعية الرابع



Non-thermal Methods (Cold sterilization
Aseptic processing
FORMULATIONSO ophthalmic Preparation
@ppharma9
MECHANISMS OF FILTRATION
Barrel Type Continuous Mixer
Batch mixing



https://t.me/ppharma9
Forwarded from Pharma/Clinical/Therapeutics (Sarmad Pharma🖤)
مهمات كلش
https://t.me/ppharma9
spray drying?😏

Drying heat-sensitive materials, changing the physical form of materials, and encapsulating

materials can spray dryers handle?
Fluid materials🤪


stage of freeze drying does sublimation occur?
pre freez😉



Which drying method is most suitable for drying heat-sensitive materials?
Freeze❤️
Here is the content you provided, organized and presented in English only:


---

Non-Thermal Drying Methods

Expression

Extraction

Absorption

Adsorption

Desiccation



---

Psychrometry Basics

Psychrometry determines vapor concentration and carrying capacity of gas.

Water vapor in a gas = humidity.

CDE curve = saturation humidity = 100% RH.

FCA = 78 grains water/pound dry air.

Dew point (60°F) = temperature at which air is fully saturated.

GK = 50% relative humidity.

Wet-bulb temperature = equilibrium between heat and moisture transfer; measured by a thermometer with a wet wick.

Dry-bulb temperature = actual air temperature; measured by a standard thermometer.



---

Drying Theory

Based on heat and mass transfer.

Driving force for heat transfer = temperature differential.



---

Evaporation & Diffusion Rates

Rate of evaporation:


Rate of diffusion:


Heat transfer methods: convection, radiation, conduction.



---

How to Increase Drying Rate

Convection: increase air flow rate, raise inlet air temperature.

Radiation: increase radiation rate.

Conduction: reduce material thickness.

Air velocity: increase to boost mass transfer coefficient.

Dehumidification: lower RH to increase humidity gradient.



---

Moisture Expression in Solids

Based on wet weight or dry weight.

LOD (Loss on Drying) = (wet weight) * 100%

MC (Moisture Content) = (dry weight) * 100%



---

Drying Phases

Initial (A-B): Heating = Cooling

Point B: Surface moisture only

Constant Rate (B-C): Evaporation = Diffusion

Critical Moisture (C): Dry spots appear; drying rate drops

First Falling Rate (C-D): Drying slows down

Second Critical Point (D): Diffusion-limited drying

Second Falling Rate (D-E): Rapid drop in drying rate

Equilibrium Moisture (E): Zero drying rate; temp and moisture constant



---

Solids Drying

Crystalline solids: Easy to dry

Amorphous solids: Hard to dry

Dryers classified by heat transfer method or sample handling



---

Drying Methods & Applications

Turbo vs. Tunnel: Turbo is faster due to continuous exposure to air.

Partially suspended in gas stream: Fluidized

Used for granular materials: Fluidized

Granules in fluidized bed are neither wet nor dry: Prevent cracking

Produces spherical, free-flowing particles: Fluidized

High and uniform drying rate: Fluidized (uniform heat exposure)

Used for fluids: Spray drying

Spray dryin, Congealing : penumatic dryer

For heat-sensitive materials; used in tablets & capsules: Spray drying

For taste masking & sustained-release: Chilling spray

High speed & temperature, short time: Flash Dryers

Uses lyophilization/sublimation: Freeze drying

Used for plasma, blood, vaccines: Freeze drying


Flash dryer: It consists of Freez +microwave
---

Freeze Drying Details

Pre-freezing: Avoid foam formation

Rotary pumps: Reduce pressure

Primary drying: Remove unbound water via sublimation (latent heat)

Secondary drying: Remove bound water



---

Microwave Drying

Converts energy to internal heat

Offers rapid heat and drying

Turns moisture into vapor (not liquid)

Does not depend on mass concentration gradients or slow liquid diffusion
__


Static_Bed
tray
bulk motion no particles movement
exposed surface

--#drying


🙂‍↔️👇🏻

A) Static-Bed System Dryers (Tray)
b) Moving-Bed System Dryers (Turbo-Tray)
C) Fluidized-Bed System Dryers
D) Pneumatic dryers It consists of 🙂‍↔️👇
Spray congealing
Flash Dryers
Spray Drye



مهمات

Fluidized bed dryer has --------than static bed dryer.
A- Rapid heat and mass transfe


non movement of the solid particles

Tray dryer
2
Forwarded from Note s4
🔹الأرقام اللي تخص جابتر الميلنك والدراينك

🔸Coarse / size large 20-mesh

🔸intermediate / 20-200mesh
(74-840) micron

🔸Fine for particles /smaller than 200 - mesh

🔸Hammer mill used for
granulation (16-mesh) ,miling crystalline (120-mesh)

🔸Cutter mill

Horizontal rotor with 2 to 12 knives
Turning from 200 to 900

🔸Roller mile / two to five smooth roller

Two cylindrical rolls mounted horizontally

🔸Hammer Miill / using high speed rotor(10.000 rpm )
Size reduction of 20-40

🔸Fluid energy mill
At pressure of 100 to 150 pound per square inch (psi)

🔸Moisture content/more than 5%water hinder comminution and produce a sticky mass
🔸Greater than 50% / slurry or
fluid suspension

🔹جابتر الدراينك

🔺Moving bed system / rotating slowly at ( 0.1 to 1.0 ) rpm

🔺Flash dryer / velocity 3000-6000 at temperature / 300-1300 air stream

🔺Pre - freezing below or at -20 C
#drying
#milling
هسه نجي نحچي شلون نختار الفلتر المناسب!
أول شي راح احدد الهدف من هايه العملية
. *يا اما انريد sterilizing filtration
هنا لازم تكون size مالت pore 0.2
*يا اما انريد clarification
هنا لتزم نستخدم
* plate and frame filter *woven-fiber filter.

زين هسه شلون راح نختار حجم pore

هنا لازم يكون size مالت proe أصغر من أصغر particle نريد نزيلها .
شلون راح احسب filtration surface area
*filter medium
*pore size
*required flow rate
*pressure differentials
هسه اذ كانت viscosity مالت liquid تختلف عن viscosity مالت water شنو راح اسوي!
راح اقسم water flow rate ع viscosity مالت liquid
ليش انسوي هيج
ع مود نحصل ع approximate intial flow rate لل liquid
ب pharmaceutical requirement ما راح نستخدم نوع واحد من filter ليش
صيدلي الصناعي لازم يحقق شنو
يحقق balance بين شنو
*filter media
*equipment capabilities
*slurry characteristics
*quality specification for the final product
ومرات راح نستخدم batch filter وراح يكون يا اما
*surface
*depth filtration
FILTER SELECTION